1. MESIAL TEMPORAL SCLEROSIS REVERSED SYMPTOMS WITH HOMOEOPATHY Dr. Aparna Singh

2. LEFT MTS where the arrow points at the lesion ATROPHY AND GLIOSIS OF THE NEURONAL CELLS

3. 17/07/2014 WAS PUT ON ANTI-EPILEPTIC DRUGS, EVEN WHEN THERE WERE NO SEIZURES- Max Hosp Neurophysician

4. NEURONAL LOSS The condition called mesial temporal sclerosis is closely related to temporal lobe epilepsy, a type of partial (focal) epilepsy in which the seizure initiation point can be identified within the temporal lobe of the brain. Mesial temporal sclerosis is the loss of neurons and scarring of the deepest portion of the temporal lobe and is associated with certain brain injuries. The condition called mesial temporal sclerosis is closely related to temporal lobe epilepsy, a type of partial (focal) epilepsy in which the seizure initiation point can be identified within the temporal lobe of the brain. Mesial temporal sclerosis is the loss of neurons and scarring of the deepest portion of the temporal lobe and is associated with certain brain injuries.

5. Brain damage from traumatic injury, infection, a brain tumor, a lack of oxygen to the brain, or uncontrolled seizures is thought to cause the scar tissue to form, particularly in the hippocampus, a region of the temporal lobe. The region begins to atrophy; neurons die and scar tissue forms. This damage is thought to be a significant cause of temporal lobe epilepsy. In fact, 70 percent of temporal lobe epilepsy patients have some degree of mesial temporal sclerosis. It also appears that the mesial temporal sclerosis can be worsened by additional seizures.

6. Possible Causes Aging Aging Although the hippocampal sclerosis is relatively commonly found among elderly people (≈10% of individuals over the age of 85 years), association between this disease and ageing remains unknown. Although the hippocampal sclerosis is relatively commonly found among elderly people (≈10% of individuals over the age of 85 years), association between this disease and ageing remains unknown.

7. Vascular risk factors There were also observations that hippocampal sclerosis was associated with vascular risk factors. Hippocampal sclerosis cases were more likely than Alzheimer's disease to have had a history of stroke or hypertension, evidence of small vessel disease but less likely to have had diabetes mellitus There were also observations that hippocampal sclerosis was associated with vascular risk factors. Hippocampal sclerosis cases were more likely than Alzheimer's disease to have had a history of stroke or hypertension, evidence of small vessel disease but less likely to have had diabetes mellitus

8. Socioeconomic status Socioeconomic correlates of health have been well established in the study of heart disease, lung cancer, and diabetes. Many of the explanations for the increased incidence of these conditions in people with lower socioeconomic status (SES) suggest they are the result of poor diet, low levels of exercise, dangerous jobs (exposure to toxins etc.) and increased levels of smoking and alcohol intake. Socioeconomic correlates of health have been well established in the study of heart disease, lung cancer, and diabetes. Many of the explanations for the increased incidence of these conditions in people with lower socioeconomic status (SES) suggest they are the result of poor diet, low levels of exercise, dangerous jobs (exposure to toxins etc.) and increased levels of smoking and alcohol intake.

9. Symptoms Mesial temporal sclerosis usually results in partial (focal) epilepsy. This seizure disorder can cause a variety of symptoms such as strange sensations, changes in behavior or emotions, muscle spasms, or convulsions, memory loss. The seizures usually are localized in the brain, but they may spread to become generalized seizures, which involve the entire brain and may cause a sudden loss of awareness or consciousness. Mesial temporal sclerosis usually results in partial (focal) epilepsy. This seizure disorder can cause a variety of symptoms such as strange sensations, changes in behavior or emotions, muscle spasms, or convulsions, memory loss. The seizures usually are localized in the brain, but they may spread to become generalized seizures, which involve the entire brain and may cause a sudden loss of awareness or consciousness.

10. Symptoms Generally, hippocampal sclerosis comes with epilepsy. It is clarified the nature of insults that most likely cause hippocampal sclerosis and initiate the epileptogenic process. Apart from the chronic nature of epilepsy, hippocampal sclerosis was shown to have an important role in internal cardiac autonomic dysfunction. Patients with left hippocampal sclerosis had more severe parasympathetic dysfunction as compared with those with right hippocampal sclerosis. In young individuals, it is commonly recognized as Mesial temporal sclerosis with Temporal Lobe Epilepsy(TLE). On the other hand, it is an often unrecognized cause of cognitive decline, typically presenting with severe memory loss.

11. Diagnosis The changes associated with mesial temporal sclerosis are usually identifiable on a magnetic resonance imaging (MRI) scan. The changes associated with mesial temporal sclerosis are usually identifiable on a magnetic resonance imaging (MRI) scan.

12. Conventional Treatment ANTI EPILEPTIC DRUGS ANTI EPILEPTIC DRUGS SURGERY-The assessment of the extent of mesial temporal sclerosis is important because it can be a good indicator of the outcome for patients undergoing temporal lobectomy to control seizures. For this procedure, the part of the brain containing the point at which the seizures start is removed. The best outcomes for the surgery are in patients with mesial temporal sclerosis on only one side of the brain. Also, the best outcomes are achieved with complete removal of the sclerotic medial temporal structures. This is the single most common surgery for patients with medically refractory epilepsy, has a high rate of eliminating seizures and is associated with a low incidence of significant new neurological impairments. SURGERY-The assessment of the extent of mesial temporal sclerosis is important because it can be a good indicator of the outcome for patients undergoing temporal lobectomy to control seizures. For this procedure, the part of the brain containing the point at which the seizures start is removed. The best outcomes for the surgery are in patients with mesial temporal sclerosis on only one side of the brain. Also, the best outcomes are achieved with complete removal of the sclerotic medial temporal structures. This is the single most common surgery for patients with medically refractory epilepsy, has a high rate of eliminating seizures and is associated with a low incidence of significant new neurological impairments.

13. NOW THE CASE IN PARTICULAR A 38 yr old male, overweight, had been seeing me for the past 10 years off and on for his health issues, mainly ureteric calculi, and pain renal region, at times left and other times right. Had been excreting calculi till 1 yr ago. He has been now in the habit of chewing gutka, paan masala for the past 6-8 yrs and also takes alcohol daily, for the past 3-4 years.Eats rich food and is a non vegetarian, no exercise, also has a fatty liver. A 38 yr old male, overweight, had been seeing me for the past 10 years off and on for his health issues, mainly ureteric calculi, and pain renal region, at times left and other times right. Had been excreting calculi till 1 yr ago. He has been now in the habit of chewing gutka, paan masala for the past 6-8 yrs and also takes alcohol daily, for the past 3-4 years.Eats rich food and is a non vegetarian, no exercise, also has a fatty liver.

14. ONSET. On 13 th July 2014, Sunday, he took a tab in the morn- allop. To check the loose stools which he had in the morning, the same evening his daughter’s heavy board fell on his toe and he was in extreme pain and rushed to some local allop physician who prescribed analgesics. On 15 th July noon as he was riding his bike, he experienced some abnormal sensation of fluttering, in the left side of chest and immediately stopped his bike and stood. He went on having the sensation for about 2-5 minutes and then subsided, only to re occur every 20 min to 30 minutes, he rushed the same night to synergy hospital and was admitted for observation for the night for any cardiac cause. Next day, was discharged and told that ECG is normal and it is not related to cardiac cause. Aft paying the bill of 15 K he came back.

15. Case (contd.) On 17 th July 2014, he noticed that he was also having a slur in his speech, while this episode of feeling cold, and almost shuddering with coldness of left side of the body only, a wave like sensation originating from chest and moving both up and down on left limbs and towards face with piloerection of hair of arm and lacrimation from left eye. So I went to see a neuro in Max. He advised MRI- in which a neurological disorder was confirmed-LEFT MTS. On 17 th July 2014, he noticed that he was also having a slur in his speech, while this episode of feeling cold, and almost shuddering with coldness of left side of the body only, a wave like sensation originating from chest and moving both up and down on left limbs and towards face with piloerection of hair of arm and lacrimation from left eye. So I went to see a neuro in Max. He advised MRI- in which a neurological disorder was confirmed-LEFT MTS.

16. NOTES BY MAX NEURO Dr Rohtash sharma was the neurophysician, he is well known in Doon now

17. PRESCRIPTION BY MAX NEURO ANTI EPILEPTICS DRUGS HAVE BEEN PRESCRIBED

18. IN HIS OWN WORDS 22 nd July 2014 22 nd July 2014 6 months ago also I had some complaints, of ghabrahat etc, which I neglected and it got better on its own. 6 months ago also I had some complaints, of ghabrahat etc, which I neglected and it got better on its own. NOW I HAVE THIS LEFT SIDED COMPLAINT NOW I HAVE THIS LEFT SIDED COMPLAINT SHIVERING FEELING WITH GHABRAHAT FROM CHEST TRAVELS TO UPPER LIMB AND LOWER LIMB SHIVERING FEELING WITH GHABRAHAT FROM CHEST TRAVELS TO UPPER LIMB AND LOWER LIMB bolne mei ladkhadahat, bhi hoti hai saath saath, bolne mei ladkhadahat, bhi hoti hai saath saath, pehle cold lagta hai, shivering hoti hai pehle cold lagta hai, shivering hoti hai FEAR HOTA HAI, DARR LAGTA HAI, ghabrahat I feel in chest region FEAR HOTA HAI, DARR LAGTA HAI, ghabrahat I feel in chest region WITHDRAWAL OF ALCOHOL AND TABACCO.. Aft that day have stopped taking alcohol and tobacco WITHDRAWAL OF ALCOHOL AND TABACCO.. Aft that day have stopped taking alcohol and tobacco

19. PEAK OF SUMMER AND NO FAN/A.C Since it is peak of summers, I want to have the right side of body under A.C, and left side covered by blanket, these sensations are coming every 20 min, under blanket and covers, little longer period of say 30 min. I am not even able to use fan because I feel cold on my left side and the whole episode reappears more frequently if I use fan.

20. My family and I are in great distress, since I have been told by neuro that I am not supposed to drive, since I may black out and fall from a scooter, my car may meet an accident under Anti epileptics. Since I am taking these drugs, now even if a dog barks, I get startled, I don’t want to hear the sound of t.v. I feel sleepy and misearble aft these drugs.

21. GELSEMIUM IS THE PERFECT MATCH Gelsemium 200 was given by mouth and aft this one dose, he said the next episode came aft 40 minutes and the intensity of symptoms was less- he felt less cold the wave started from chest but didn’t go into limb, only ascended upwards, piloerection was there but less in intensity Lacrimation lasted for less time and was also less Slur of speech also less, Ghabrahat was there and episode went off earlier than prev episodes.

22. BRAIN AFFECTIONS OF Bry, Nux vom, Gels are the 1 st 3 rems

23. J.H CLARKE- Amaurosis. Anterior crural neuralgia. Aphonia. Astigmatism. Bilious fever. *Brain, *affections of. Cerebrospinal meningitis. Choroiditis. Colds. *Constipation. Convulsions. Deafness. *Dengue fever. Diarrhoea. *Diphtheria. *Dupuytren’s *contraction. Dysentery. *Dysmenia. Emotions, effects of. Epilepsy. *Eyes, *affection of. *Fever. Fright. Gonorrhea. Hay-fever. *Headache. Heat, effects of. Heart, diseases of. Hydro-salpingitis. Hysteria. Influenza. Intermittent fever. Jaundice. Labour. Liver, affection of. Locomotor ataxia. Measles. *Meningitis. *Menstruation, *painful, suppressed. Metrorrhagia. *Myalgia. Neuralgia. Nystagmus. *OEsophagus, *stricture of. Paralysis. Paralysis agitans. Paraplegia. Pregnancy, albuminuria of. Ptosis. Puerperal convulsions. *Remittent fever. Retina, detachment of. Rheumatism. Sexual excess, effects of. *Sleep, *disordered. Spasms. Sun-headache. Sunstroke. Teething. Tic-douloureux. Tobacco, effects of. *Tongue, *affections of. Toothache. *Tremors. *Uterus, *affections of. *Vertigo. *Voice, loss of. Writers’ cramp.

24. Neurotic symptoms in cigar- makers, impotence, palpitation. Aggravation. – Damp weather; before a thunderstorm; mental emotion or excitement; bad news; tobacco smoking; when thinking of his ailments; when spoken to of his loss.

25. 24th July –shifted to LM On 24 th July he reported relief, but said that the wave is still coming, albeit in a lesser intensity. Due to persistence of symptoms he was shifted to LM potencies of GELSEMIUM LM2 bd.

26. STOPPED AFT 3 DAYS, on 26 th July 2014 Aft 3 days of Gelsemium LM2, given twice a day- I feel much better The wave sensation is almost gone Don’t feel cold, no piloerection on arms and legs No slur, no lacrimation But on 4 th day I felt symptoms increasing again STOP GELS LM2… ONLY ON SAC LAC AFT THAT.

27. 6 th NOV 2014 Till 6 th Nov 2014, he was on sac lac and then started to c/o – Left sided headache always worse aft sleeping Even if I sleep in daytime, I get this headache Morn when I wake up I get this headache of dull aching nature, feel sleepy and groggy, with a feeling of palpitation. An hour aft I wake up it gets better, I have stopped sleeping in daytime, even though I want to.

28. LACHESIS LM2 Based on left sidedness of headache, And Worse AFTER SLEEP, either day or night. LACH LM2 was given bd

29. LATER MRI In Jan 2015 MRI was done in Delhi, which revealed same findings of atrophy and left MTS. Another MRI was done in Jan 2015 itself, to see the vascularity, blood flow to the brain, which was absolutely normal, no obstruction of any vascular channel.

30. JOINED JOB IN JAN 2015 He has again joined back, has got a better raise and a better job. He is not experiencing any of the previous symptoms.

31. WHAT IS TO BE LEARNT HERE A SIMPLE MEDICINE CAN CURE/INITIATE CURE EVEN OF A COMPLICATED DISORDER. MIASM CONSIDERATION IS NOT NECESSARY, WHEN THE TOTALITY IS CHARACTERISTIC AND SPEAKS FOR THE REMEDY. DELETE FROM THE MIND DISEASE –REMEDY RELATIONS- like for viral/seasonall flus, gels ars acon etc, for joint pains, rhus tox,. WHO KNEW THAT REVERSAL OF NEURONAL DAMAGE MANIFESTATIONS CAN BE INITIATED BY YELLOW JASMINE. EVEN A HOMOEOPATH CAN BUNGLE CASE IF TOTALITY IS NOT CONSIDERED.( If Miasm is considered in lieu of totality) ATROPHY/SCAR IN BRAIN REMAINS-SYMPTOMS VANISH.