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Pesticide Health Effects Medical Education Database (PHEMED) Paraquat Toxicity and Treatment.

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Presentation on theme: "Pesticide Health Effects Medical Education Database (PHEMED) Paraquat Toxicity and Treatment."— Presentation transcript:

1 Pesticide Health Effects Medical Education Database (PHEMED) Paraquat Toxicity and Treatment

2 Pesticide Health Effects Medical Education Database (PHEMED) Paraquat: is very toxic to the skin and mucous membranes (inside of mouth, nose, eyes). Particles are considered too large for respiratory absorption, but once paraquat in the system (through broken skin or mucous membranes) it migrates to the lungs because of its oxygen seeking properties. If ingested it is very lethal, survival rates are generally poor. Skin: 1. dryness, cracks 2. erythema (redness) 3. blistering 4. ulcerations Nails: 1. discoloration 2. splitting nails 3. loss of nails Respiratory 1. cough 2. nosebleeds 3. sore throat Eyes: 1. conjunctivitis (irritation) 2. ulceration, scarring, blindness Ingestion: 1. pulmonary fibrosis 2. multi-system organ failure, specifically respiratory failure kidney failure Paraquat

3 Pesticide Health Effects Medical Education Database (PHEMED) Ingestion- life threatening effects on GI, kidney, liver and heart LD mg/kg or 10-15ml in 20% solution Most lethal in lungs – but toxicity from inhalation rare Mechanism – generation of free radicals with oxidative damage to lung tissue Pulmonary fibrosis w/in 7-10 day causes death Toxicology

4 Pesticide Health Effects Medical Education Database (PHEMED) Source: Richards, Kerry Penn State University Extension Service

5 Pesticide Health Effects Medical Education Database (PHEMED) LD 50 Lethal Dose = Amount of chemical it takes to kill 50% of an experimental population

6 Pesticide Health Effects Medical Education Database (PHEMED) Source: Richards, Kerry Penn State University Extension Service

7 Pesticide Health Effects Medical Education Database (PHEMED) Source: Richards, Kerry Penn State University Extension Service

8 Pesticide Health Effects Medical Education Database (PHEMED) Adverse effects of Exposure GI: mucous membrane swelling, edema, ulcerations Renal –proximal renal tubule damage –reversible Cardiac – focal necrosis myocardium Cerebral – edema and brain damage Smoking paraquat contaminated marijuana: pyrolyzed to non toxic dipyridyl

9 Pesticide Health Effects Medical Education Database (PHEMED) Toxicology (Skin) Local skin damage  contact dermatitis Prolonged contact  blisters, abrasion, ulcerations, finger nail changes Slow absorption via intact skin Abraded or eroded skin absorption efficient

10 Pesticide Health Effects Medical Education Database (PHEMED) Treatment of Contact Dermatitis from Paraquat Upon contact, flush the skin with copious amounts of water Mild skin reactions are usually self limiting as long as there is no more contact More severe reaction should be treated by a dermatologist

11 Pesticide Health Effects Medical Education Database (PHEMED) Factors Leading to Illness Event What the product used for its intended purpose? –Is it registered? –Is it registered for use on wheat & alfalfa? –Is it restricted? What the product used correctly? What factors could have lead the worker not to take action to mitigate the effects?


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