1. Efficacy of Production Drugs to Assist in Herd-Health Upgrades David K. Bishop* and Tim Orban Southern Section Meetings – Orlando, Florida

2. “12 Non-negotiable Aspects of Gilt Development” Univ. Alberta/Prairie Swine Centre 1.Recognize the Gilt Development Unit 2.Set goals, Clarify rules, & Provide training 3.Meet gilt breeding targets 4.Provide steady boar supply 5.Make swift changes to improved lines 6.Evaluate puberty stimulation, isolation/acclimation

3. “12 Non-negotiable Aspects of Gilt Development” Univ. Alberta/Prairie Swine Centre 7. Start puberty stimulation -30 d from max. market 8. Identify the most fertile females 9. Breed based on weight (not age) 10. Avoid slow growing gilt 11. Use pharmacological aids wisely 12. Emphasize data recording

4. Standard Entry Protocol Week 1 Week 2 Week 3 Large White, PRRS naive gilts were delivered on Wednesdays (28-29 weeks of age) Estrus detection commencing on Sunday (Week 29-30) Heat-no-service (HNS) Program Target matings = Tuesday, Week 32

5. Standard Entry Protocol (cont.) Non-responders at 23 days- given PG-600 ® Movements on Fridays to Breeding Barn (by color) “Excess” breeds were placed on MATRIX ®  Serum gonadotropin (PMSG) 400 I.U. (FSH like)  Chorionic gonadotropin (HCG) 200 I.U. (LH like)  Single, 5 ml dose  Altrenogest (2.2 mg/ml) applied to feed 15 mg/hd/day (Progesterone like)  Duration = 5-12 days or 14 day standard program  Daily dose of 6.8 mL “in the mouth”

6. 15 10 15 20 2530 Randomly Cycling Percentage of Delivery in Estrus 15 10 15 20 2530 Shipping Induced Estrus 40 30 20 10 0 40 30 20 10 0 Scenarios of Gilt Heat

7. 15 10 15 20 2530 Randomly Cycling Percentage of Delivery in Estrus 15 10 15 20 2530 Shipping Induced Estrus 40 30 20 10 0 40 30 20 10 0 Scenarios of Gilt Heat: Modified

8. Treatments Trt 1- Normal entry, HNS, Mating as needed Trt 2 – HNS + MATRIX® for 14 days Trt 3- HNS + MATRIX through Wednesday Trt 4- PG-600 induced + 5/12 MATRIX (d 14) Trt-5- PG-600 induced + MATRIX for 14 days

9. Cumulative Response to Treatment with MATRIX®

10. Influence of Treatments on Total Born per Litter TreatmentnMeanStd. Dev.Min.Max. Normal208811.672.99121 HNS + 144511.293.27316 HNS + 5/125012.623.38120 PG + 5/1221012.172.84219 PG + 1414112.392.89319 (P = 0.145: mean = 11.76)

11. Influence of Treatments on Pigs Born Alive per Litter TreatmentnMeanStd. Dev.Min.Max. Normal208810.662.98018 HNS + 144510.582.98315 HNS + 5/125011.363.18117 PG + 5/1221011.192.99219 PG + 1414111.172.99118 (P = 0.45: mean = 10.74)

12. Influence of Treatments on % of Litters with < 7 Born-Alive

13. Fate of PG-600 - treated gilts HNS recorded on 84.6% of deliveries: 15.4% gilts needed assistance to “fit” system Of treatments: Average of 79.6% showed estrus in 10 days: 49.7 % on Day 5 (Tuesday) Fallout post mating = 4 % lame, culled or died (preg?) 4.7 % US + : failed to farrow (movements?) 2% Removed after movement

14. Conclusions: 1.Procedures can synchronize detectable estrus 2.Even with “Good” entry process: stimulation may be necessary on a percentage of gilts 3. Timely use of PG-600 can serve to evaluate the stimulation/detection process 4. Effective use of boar stimulation and estrus detection can reduce treatment days needed for MATRIX without loss of performance

15. Implementation: Reasonable response rates and limited treatment days should be considered when developing strategies for highly productive swine units. Efforts to improve natural stimulation and detection will add value to pharmacological therapies or reduce the cost per treated female without loss of response.

16. “Thanks for support”