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Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com Dr. CN Ramchand CEO, Saksin lifesciences Pvt. Ltd Chennai.

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Presentation on theme: "Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai - 600 113| www.saksinlife.com Dr. CN Ramchand CEO, Saksin lifesciences Pvt. Ltd Chennai."— Presentation transcript:

1 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | Dr. CN Ramchand CEO, Saksin lifesciences Pvt. Ltd Chennai & San Francisco

2 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | My experienc es Funding and development of biotech start-ups Overview -India & in Kerala 2 General outline

3 Vice President & Head of New Drug Discovery Director & World Wide executive member Chief Scientific Officer President and CEO President & CEO Advisor Education Early days Semi- Entrepreneur

4 Scientific publications = > 150 Patents => 60 Conferences organized => 8 4 Nanoparticles for biological applications Curcumin based products The Fish oil story Value added basic research

5 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | 5

6 6 Major players in the country

7 Advantage India Skilled manpower Large consumer base Government funding/Venture funding Good IT support English proficiency Raw materials aplenty Ancient knowledge Ecological /Cultural diversity Agricultural base strong

8 Indian biotech in global context Leadership vacuum Publications and Patents still less Research in Industry not significant yet No dialogue between academics and industries Less number of startups Academia not ready to take risk for a venture Less number of R&D Institutes & Universities Shortage on mentors, advisors Lack of awareness about opportunities

9 9 One mentionable point University’s role in supporting Innovation & Entrepreneurship Spun off from Oxford University in 1993 Spun off from Oxford University in 1959 Spun off from Cavendish Laboratory at the University of Cambridge in 2000 Spun off from Carnegie Mellon University in 1994

10 10 CountryPeriodNo. Spinouts US Canada France Netherlands s 300 Australia UK

11 11 Columbia University- >100 spin offs

12 12

13 Roadmap to success

14 Learning by example 14

15 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | Reverse pharmacology 15

16 Conventional drug discovery Associated issues Strategy 16

17 17

18 Curcumin Capsaicin 6-Gingerol Lycopene Resvertrol Diallyl sulphide Indole-3-carbinol Source Active Phytochemical Application Caffeic acid phenethyl ester Anti-inflammatory, antioxidant, antiamyloid, antiarthritic. Long-term analgesic, anti-inflammary, anti-psoriasis. Antitumor, anti-carcenogenic, antiarthritic. Strong antioxidant, Anti-inflammatory, anti-HIV. Anti-ageing, antioxidant, antidiabetic. Neuroprotective, Cardioprotective antidiabetic, antiviral. Inhibits H. pylori, anticarcinogenic. Anticarcinogenic, antioxidant, antiatherogenic. Antimicrobial, antioxidant. Anti-inflammatory, antimitogenic, antifungal. Sulphoraphane Epicatechin gallate 18

19 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | 19 Development of Novel biologics at Saksin Lifesciences Wet AMD

20 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai |

21 Age related AMD Dry, or Atrophic or Non-neovascular macular degeneration Wet or Exudative or Neovascular macular degeneration Abnormal blood vessels begin to grow underneath the retina Blood vessels may leak fluid or blood, blurring or distorting central vision. Macula Optic disc Wet AMD Dry AMD Fovea centralis Disease causing factor

22 Receptor in eyesDisease causing factor Disease complex formed AMD Anti-VEGF Fab Disease causing factor No AMD No complex formed Mechanism of the novel drug

23 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | DNA extraction using magnetic nanoparticles

24 Magnetic nanoparticles

25 DNA extraction Magnetic nanoparticles using Applicable to various biological systems Quick and robust Can be performed without using sophisticated instruments High yield and purity Easy to use for large number of samples

26 Patent application number 5676/CHE/2014 UK patent application GB Patent application number 1067/MUM/2006

27 GM crops, Micro-propagation, Bio-fertilizers & Bio- pesticides, Animal Improvement r-DNA Products, Vaccines & Diagnostics, Monoclonal Antibodies, Stem Cells, Tissue Specific delivery methods Enzymes, Fermentation based Products & Food, Biotech Instruments & Equipment, Bio-energy & Bio-fuel, Bioinformatics, Bio-mining Soil & Water remediation, Bio-safety & GMOs Viable applications HealthcareAgricultureEnvironmentIndustry 27

28 28

29 Technology development fundsTechnology in-licensing funds Market entry funds Funds for patent protection Technology scale-up /validation/de-risking funds Expansion funds 29

30 Funding Government of India/Kerala Venture capitalist 30 For more information visit : in/funding

31 Department of Scientific & Industrial Research (DSIR) Ministry of Micro Small Medium Enterprises (MoMSME) Department of Science and Technology (DST) National Innovation Foundation (NIF) Kerala Venture Capital Fund National Research Development Corporation (NRDC) Department of Bio-Technology (DBT) World Bank & ICICI Bank collaboration Bill and Melinda Gates Foundation Amrita Vishwa Vidhyapeetham- TBI 31 Major funding sources

32 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | Biotechnology in India/Kerala-Thrust areas 32

33 Module No:306, 3 rd Floor, Phase2, Ticel Bio Park, Taramani, Chennai | 33 Advantage Kerala

34 34

35 35 Prebiotics & Probiotics Agri-foods Pharmaco- genomics and Nutri- genomics FCR enhancers

36 Regional Research Laboratory, Thiruvananthapuram Kerala Forest Research Institute, Peechi Kerala Agricultural University, Vellayani Central Tuber Crops Research Institute, Thiruvananthapuram Central Institute of Fisheries Technology, Ernakulam Rubber Research Institute of India, Kottayam Central Coir Research Institute, Kalavoor, Alappuzha Central Marine Fisheries Research Institute, Ernakulam National Research Center for Oil Palm (Regional Center), Palode, Thiruvananthapuram Indian Cardamom Research Institute, Myladumpara, Idukki Indian Institute of Spices Research, Kozhikode Central Plantation Crops Research Institute, Kasargod Regional Cancer Center, Thiruvananthapuram Center for Water Resources Development and Management, Kunnamangalam, Kozhikode Major research institutes in Kerala 36

37 37


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