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Saksin lifesciences Pvt. Ltd Chennai & San Francisco

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Presentation on theme: "Saksin lifesciences Pvt. Ltd Chennai & San Francisco"— Presentation transcript:

1 Saksin lifesciences Pvt. Ltd Chennai & San Francisco
Dr. CN Ramchand CEO, Saksin lifesciences Pvt. Ltd Chennai & San Francisco

2 Funding and development of biotech start-ups
General outline Funding and development of biotech start-ups My experiences Overview-India & in Kerala

3 Vice President & Head of
Education Vice President & Head of New Drug Discovery Director & World Wide executive member Early days Chief Scientific Officer President and CEO Entrepreneur Semi- President & CEO Advisor Entrepreneur

4 Value added basic research
Scientific publications= > 150 Conferences organized => 8 Patents => 60 Value added basic research The Fish oil story Curcumin based products Nanoparticles for biological applications


6 Major players in the country

7 Advantage India Government funding/Venture funding Skilled manpower
Ancient knowledge Ecological /Cultural diversity Agricultural base strong Good IT support Large consumer base English proficiency Raw materials aplenty

8 Indian biotech in global context
Leadership vacuum Less number of R&D Institutes & Universities Research in Industry not significant yet Shortage on mentors, advisors Lack of awareness about opportunities No dialogue between academics and industries Publications and Patents still less Less number of startups Academia not ready to take risk for a venture

9 One mentionable point University’s role in supporting Innovation & Entrepreneurship Spun off from Oxford University in 1993 Spun off from Oxford University in 1959 Spun off from Cavendish Laboratory at the University of Cambridge in 2000 Spun off from Carnegie Mellon University in 1994

10 Country Period No. Spinouts US 4543 Canada 1100 France 1230 Netherlands s 300 Australia 97 UK 1650

11 Columbia University- >100 spin offs


13 Roadmap to success

14 Learning by example

15 Reverse pharmacology

16 Conventional drug discovery
Associated issues Strategy


18 Source Active Phytochemical Application Source Active Phytochemical
Neuroprotective, Cardioprotective antidiabetic, antiviral. Anti-inflammatory, antioxidant, antiamyloid, antiarthritic. Resvertrol Curcumin Caffeic acid phenethyl ester Anti-inflammatory, antimitogenic, antifungal. Long-term analgesic, anti-inflammary, anti-psoriasis. Capsaicin Antimicrobial, antioxidant. Antitumor, anti-carcenogenic, antiarthritic. Diallyl sulphide 6-Gingerol Strong antioxidant, Anti-inflammatory, anti-HIV. Anticarcinogenic, antioxidant, antiatherogenic. Indole-3-carbinol Epicatechin gallate Anti-ageing, antioxidant, antidiabetic. Lycopene Inhibits H. pylori, anticarcinogenic. Sulphoraphane

19 Development of Novel biologics at Saksin Lifesciences


21 Age related AMD Dry, or Atrophic or Non-neovascular macular degeneration Wet or Exudative or Neovascular macular degeneration Abnormal blood vessels begin to grow underneath the retina Blood vessels may leak fluid or blood, blurring or distorting central vision. Macula Optic disc Wet AMD Dry AMD Fovea centralis Disease causing factor

22 Mechanism of the novel drug
Receptor in eyes Disease causing factor Disease complex formed AMD Disease causing factor No AMD No complex formed Anti-VEGF Fab

23 DNA extraction using magnetic nanoparticles

24 Magnetic nanoparticles

25 Magnetic nanoparticles
Applicable to various biological systems Can be performed without using sophisticated instruments DNA extraction Magnetic nanoparticles using Easy to use for large number of samples High yield and purity Quick and robust

26 Patent application number 1067/MUM/2006
UK patent application GB Patent application number 1067/MUM/2006 Patent application number 5676/CHE/2014

27 Soil & Water remediation, Bio-safety & GMOs
Viable applications Healthcare Agriculture Environment Industry r-DNA Products, Vaccines & Diagnostics, Monoclonal Antibodies, Stem Cells, Tissue Specific delivery methods GM crops, Micro-propagation, Bio-fertilizers & Bio-pesticides, Animal Improvement Soil & Water remediation, Bio-safety & GMOs Enzymes , Fermentation based Products & Food, Biotech Instruments & Equipment, Bio-energy & Bio-fuel, Bioinformatics, Bio-mining


29 Technology development funds Technology in-licensing funds
Market entry funds Funds for patent protection Technology scale-up /validation/de-risking funds Expansion funds

30 Government of India/Kerala Venture capitalist
Funding Government of India/Kerala Venture capitalist For more information visit :

31 Major funding sources National Research Development Corporation (NRDC)
Department of Scientific & Industrial Research (DSIR) Major funding sources Ministry of Micro Small Medium Enterprises (MoMSME) Department of Bio-Technology (DBT) World Bank & ICICI Bank collaboration Department of Science and Technology (DST) National Innovation Foundation (NIF) Bill and Melinda Gates Foundation Amrita Vishwa Vidhyapeetham- TBI Kerala Venture Capital Fund

32 Biotechnology in India/Kerala-Thrust areas

33 Advantage Kerala


35 Prebiotics & Probiotics
Agri-foods Pharmaco-genomics and Nutri-genomics FCR enhancers

36 Major research institutes in Kerala
Regional Research Laboratory, Thiruvananthapuram Central Tuber Crops Research Institute, Thiruvananthapuram Regional Cancer Center, Thiruvananthapuram Center for Water Resources Development and Management, Kunnamangalam, Kozhikode Central Plantation Crops Research Institute, Kasargod Central Institute of Fisheries Technology, Ernakulam Kerala Agricultural University, Vellayani Major research institutes in Kerala Rubber Research Institute of India, Kottayam Indian Cardamom Research Institute, Myladumpara, Idukki National Research Center for Oil Palm (Regional Center), Palode, Thiruvananthapuram Central Coir Research Institute, Kalavoor, Alappuzha Indian Institute of Spices Research, Kozhikode Central Marine Fisheries Research Institute, Ernakulam Kerala Forest Research Institute, Peechi


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