1. Saksin lifesciences Pvt. Ltd Chennai & San Francisco
Dr. CN Ramchand
CEO,
Saksin lifesciences Pvt. Ltd
Chennai & San Francisco

2. Funding and development of biotech start-ups
General outline
Funding and development of biotech start-ups My
experiences
Overview-India & in Kerala

3. Vice President & Head of
Education
Vice President & Head of
New Drug Discovery
Director & World Wide
executive member
Early days
Chief Scientific
Officer
President and CEO
Entrepreneur
Semi-
President & CEO
Advisor
Entrepreneur

4. Value added basic research
Scientific publications= > 150
Conferences organized => 8
Patents => 60
Value added basic research
The Fish oil story
Curcumin based products
Nanoparticles for biological applications

6. Major players in the country

7. Advantage India Government funding/Venture funding Skilled manpower
Ancient knowledge
Ecological /Cultural diversity
Agricultural base strong
Good IT support
Large consumer base
English proficiency
Raw materials aplenty

8. Indian biotech in global context
Leadership vacuum
Less number of R&D Institutes & Universities
Research in Industry
not significant yet
Shortage on mentors, advisors
Lack of awareness
about opportunities
No dialogue between academics and industries
Publications and
Patents still less
Less number
of startups
Academia not ready to
take risk for a venture

9. One mentionable point
University’s role in supporting Innovation & Entrepreneurship
Spun off from Oxford University in 1993
Spun off from Oxford University in 1959
Spun off from Cavendish Laboratory at the University of Cambridge in 2000
Spun off from
Carnegie Mellon University in 1994

10. Country
Period
No. Spinouts US
4543
Canada
1100
France
1230
Netherlands s
300
Australia 97 UK
1650

11. Columbia University- >100 spin offs

13. Roadmap to success

14. Learning by example

15. Reverse pharmacology

16. Conventional drug discovery
Associated issues
Strategy

18. Source Active Phytochemical Application Source Active Phytochemical
Neuroprotective,
Cardioprotective
antidiabetic,
antiviral.
Anti-inflammatory,
antioxidant,
antiamyloid,
antiarthritic.
Resvertrol
Curcumin
Caffeic acid
phenethyl ester
Anti-inflammatory,
antimitogenic,
antifungal.
Long-term
analgesic,
anti-inflammary,
anti-psoriasis.
Capsaicin
Antimicrobial,
antioxidant.
Antitumor,
anti-carcenogenic,
antiarthritic.
Diallyl sulphide
6-Gingerol
Strong antioxidant,
Anti-inflammatory,
anti-HIV.
Anticarcinogenic,
antioxidant,
antiatherogenic.
Indole-3-carbinol
Epicatechin gallate
Anti-ageing,
antioxidant,
antidiabetic.
Lycopene
Inhibits H. pylori,
anticarcinogenic.
Sulphoraphane

19. Development of Novel biologics at Saksin Lifesciences
Wet AMD

21. Age related AMD
Dry, or Atrophic or Non-neovascular macular degeneration
Wet or Exudative or Neovascular macular degeneration
Abnormal blood vessels begin to grow underneath the retina
Blood vessels may leak fluid or blood, blurring or distorting central vision.
Macula
Optic
disc
Wet AMD
Dry AMD
Fovea centralis
Disease causing factor

22. Mechanism of the novel drug
Receptor in eyes
Disease causing factor
Disease complex formed
AMD
Disease causing factor
No AMD
No complex formed
Anti-VEGF Fab

23. DNA extraction using magnetic nanoparticles

24. Magnetic nanoparticles

25. Magnetic nanoparticles
Applicable to various biological systems
Can be performed without using sophisticated instruments
DNA extraction
Magnetic nanoparticles
using
Easy to use for large number of samples
High yield and purity
Quick and robust

26. Patent application number 1067/MUM/2006
UK patent application GB
Patent application number
1067/MUM/2006
Patent application number
5676/CHE/2014

27. Soil & Water remediation, Bio-safety & GMOs
Viable applications
Healthcare
Agriculture
Environment
Industry
r-DNA Products, Vaccines & Diagnostics, Monoclonal Antibodies, Stem Cells, Tissue Specific delivery methods
GM crops, Micro-propagation, Bio-fertilizers & Bio-pesticides, Animal Improvement
Soil & Water remediation, Bio-safety & GMOs
Enzymes , Fermentation based Products & Food, Biotech Instruments & Equipment, Bio-energy & Bio-fuel, Bioinformatics, Bio-mining

29. Technology development funds Technology in-licensing funds
Market entry funds
Funds for patent protection
Technology scale-up
/validation/de-risking funds
Expansion funds

30. Government of India/Kerala Venture capitalist
Funding
Government of India/Kerala
Venture capitalist
For more information visit :

31. Major funding sources National Research Development Corporation (NRDC)
Department of Scientific & Industrial Research (DSIR)
Major funding sources
Ministry of Micro Small Medium Enterprises (MoMSME)
Department of Bio-Technology (DBT)
World Bank & ICICI Bank collaboration
Department of Science and Technology (DST)
National Innovation Foundation (NIF)
Bill and Melinda Gates Foundation
Amrita Vishwa Vidhyapeetham- TBI
Kerala Venture Capital Fund

32. Biotechnology in India/Kerala-Thrust areas

33. Advantage Kerala

35. Prebiotics & Probiotics
Agri-foods
Pharmaco-genomics
and Nutri-genomics
FCR
enhancers

36. Major research institutes in Kerala
Regional Research Laboratory, Thiruvananthapuram
Central Tuber Crops Research Institute, Thiruvananthapuram
Regional Cancer Center, Thiruvananthapuram
Center for Water Resources Development and Management, Kunnamangalam, Kozhikode
Central Plantation Crops Research Institute, Kasargod
Central Institute of Fisheries Technology, Ernakulam
Kerala Agricultural University, Vellayani
Major research institutes in Kerala
Rubber Research Institute of India, Kottayam
Indian Cardamom Research Institute, Myladumpara, Idukki
National Research Center for Oil Palm (Regional Center), Palode, Thiruvananthapuram
Central Coir Research Institute, Kalavoor, Alappuzha
Indian Institute of Spices Research, Kozhikode
Central Marine Fisheries Research Institute, Ernakulam
Kerala Forest Research Institute, Peechi