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The Department of Biochemistry of Medical Faculty Presents now Edited by Attila Sandor SYNTHESIS of CHOLESTEROL and KETONE BODIES
Classification of lipids on chemical basis Fatty acid derivativesIsoprenoids Simple lipidsComplex lipids Triglycerids Vaxes Phospholipids Glycolipids Steroids Carotinoids Author`s picture
A C5 hydrocarbon occurring in oil but not in living organisms Lehn. 4 th ed., p.816
The way of isoprenoid synthesis (1) an enzyme of -oxidation C2+C2 = C4
The way of isoprenoid synthesis (2) C4+C2 = C6
The way of isoprenoid synthesis (3) to ketone bodies C6
C6-C=C5 C6 The way of isoprenoid synthesis (4) Formation of the final C5 unit
The action of C15 prenyltransferase (3 X 5) C5 C15 C10
The action of C15 squalene synthase (2 X 15)
Strayer 5 th ed. 26.10, p724 Formation of Squalene (2 X 15 = 30), still straight skeleton Head to Head
Cholesterol -3C Cholesterol C27 -3C
(6C X 5C)-3C = 27C, ring 17C + 2C methyl + 8C side chain Structure, nubering and origins of atoms of cholesterol Strayer, 5 th ed. 26.25 p.733
Chlesterol may be esterified with fatty acids Lehn., 4 th ed. Fig. 21-38, p.820
polyprenyltransferase C15 prenyltransferase C20 prenyltransferase Compounds built from C5 isoprenoid blocks Lehn., 4th ed. Fig. 21-48, p.828
The way of isoprenoid synthesis (3) to ketone bodies C6
HMG-CoA is a branchpoint Cleavage enzyme Reductase HMG-CoA synthase Ketone bodies Cholesterol Strayer, 5 th ed. 26.7 p.723
The two ketone bodies are interchangable
The activation of acetoacetate for the metabolism
THANK YOU FOR YOUR ATTENTION The honored audience has the opportunity now to download the pictures of this lecture Attila Sandor from here or from the intranet: CholesterolKetoneBodies.ppt
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