1. Edited by Attila Sandor The Department of Biochemistry of Medical Faculty Presents now FATTY ACID OXIDATION I The Carnitine System

2. ketone bodies Liver VLDL Fatty acids undergo  -oxidation. Interorgan relationships Lehn. old.16-3, p.483

3. CH 2 O C (CH) 7 CH CH(CH) 7 CH 3 O CH 2 O C (CH 2 ) 14 CH 3 O O palmitic acid oleic acid Stored fat (mostly triglicerides) in the human organism kcal/g kJ/g Protein: 4.1 17.2 Carbohydrate: 4.1 17.2 Fat: 9.3 38.2 Stryer, 3th ed. Fig. 20-1,p. 469

4. (  G o = -33.4 kJ/mol? (  G o = + 0.9 kJ/mol ?) Activation of Fatty Acids Lehn., 4 th ed. Fig17-5, p. 635

5. Acyl-carnitine ? Author`s picture

7.  Carnitine takes over acyl group from HSCoA, forming macroerg O-esters, by special enzymes in a reversible reaction.  This is the only enzymatic reaction of carnitine in aniamal tissues.  Forming acyl-carnitine esters transiently, carnitine is an obligatory factor in transporting fatty acids from the cytosol into the mitochondrial matrix.  The carnitine itself, the transferase enzymes and translocase (in mitochondrial mambrane) forms the carntine system. Concluding remarks about the carnitine Author`s table

8. CPT I CPT II Acyl- SCoA Carnitine Author`s picture

9. Acyl- CPT I CPT II SCoA Carnitine Acyl- T r a n s c l o c a s e Author`s picture

10. THANK YOU FOR YOUR ATTENTION The honored audience has the opportunity now to download the pictures of this lecture Attila Sandor