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DODDS & ASSOCIATES © 2014 D A & Problems and Opportunities in the Viola Section SWEA Assembly 2014 Wednesday, 11 June 2014 Sarnia, ON David Dodds, Dodds.

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Presentation on theme: "DODDS & ASSOCIATES © 2014 D A & Problems and Opportunities in the Viola Section SWEA Assembly 2014 Wednesday, 11 June 2014 Sarnia, ON David Dodds, Dodds."— Presentation transcript:

1 DODDS & ASSOCIATES © 2014 D A & Problems and Opportunities in the Viola Section SWEA Assembly 2014 Wednesday, 11 June 2014 Sarnia, ON David Dodds, Dodds & Associates

2 DODDS & ASSOCIATES © 2014 D A & Axioms (and qualifications) Corn ethanol is a fabulous success story. But there is more than corn, and more than fuel. If you are making a molecule, you are a chemist, doing chemistry. Synthetic biology is just chemistry conducted by other means. “Bio” does not change the molecule. Redox Balance It’s not the carbon, it’s the hydrogen.

3 DODDS & ASSOCIATES © 2014 D A & Why? Markets want alternative to petrochemical feedstock de-linking commodity chemical production from oil prices Hedge against carbon taxes Availability of feedstock from multiple locations; not just price, but supply-chain security Technical hurdles dropping Molecular biology, biocatalysis, fermentation technology, petrochemical processes & engineering Opportunity to use under-utilized assets and existing infrastructure

4 DODDS & ASSOCIATES © 2014 D A & Some History 1833:diastase (amylase) isolated from barley, shown to convert starch to sugar 1860:Pasteur showed yeast transforms sugar to alcohol and butanol (1861) 1860s:vitalistic and non-vitalistic theories of organized and un-organized "ferments” (Pasteur, Liebig, and Berzelius) 1876:Kühne coined term "enzyme" ("in yeast") for organized ferments 1881:Frémy and beginning of industrial production of lactic acid 1898:last vitalistic paper; F.R. Japp, Nature, 58, 482 (1898) 1905:biological production of acetone discovered by Shardinger 1912:Fernbach patents acetone and butanol production 1916:Immobilized invertase used industrially 1919:Weizmann patents acetone and butanol production (GB4845, US ) 1950:2/3 of all US butanol (~30 MM lbs), 50% of ethanol (~225 MM gal) and 10% of acetone made from molasses & starch

5 DODDS & ASSOCIATES © 2014 D A & We Have Done This Before H. Bunn, Industrial and Engineering Chemistry, 44(9),

6 DODDS & ASSOCIATES © 2014 D A & 2013 Numbers (US) 75% vs 2% In 2005, ratio was 71% vs 3.5%, with economic impact of $365BB vs $375BB In 2013 had dropped to $255BB EIA November _mbbl_m_cur.htm

7 DODDS & ASSOCIATES © 2014 D A & Making, and buying, less…. ….losing integration and value

8 DODDS & ASSOCIATES © 2014 D A & Chemical Feedstock: (just corn, just glucose) US 2013 corn production; 13.8 BB bushels = 350 MM tonnes 1 tonne corn= 590 kgs glucose (C 6 H 12 O 6 ) = 275 kgs “CH 2 equivalent” = 2 bbl oil (1 bbl oil = 139 kgs) So current corn production on a simple “CH 2 ” weight basis = 700 MM bbl oil US oil consumption (2012) = 18.5 MM bbl/day= 6.75 BB bbl/yr 2% of oil consumed is for chemical feedstocks= BB bbl/yr On a simple weight basis, ~20% of current US corn crop could theoretically satisfy US chemical feedstock production Currently, ~42% of current US corn crop goes to EtOH Estimated that the entire 1.3 BB tons annual renewable biomass would replace about half of the US transportation fuel

9 DODDS & ASSOCIATES © 2014 D A & Problems Lack of Champion for Chemicals US DoE has energy mandate, which includes fuels USDA has biomass mandate - for eating, building, burning, etc. Lack of Standards ASTM D6866 is fine, but not enough What is “renewable”? “sequestered”? “bio-based”? Lack of Policy US federal planning is minimal at best RFS/RINS, TSCA, R&D tax credits Lack of Funding The über problem (a product of taxation, R&D tax credit uncertainty, etc.) Cost-sharing, incubators, consortia; these all cost money….

10 DODDS & ASSOCIATES © 2014 D A & The über Problem 30 start-ups in the $BB Valuation Club; 1 bioenergy (#17), 1 solar (#29) Trends in investment are short, fashionable, and risk-adverse Money from the private sector (corporations) is very hard to attract

11 DODDS & ASSOCIATES © 2014 D A & Operational Opportunities Advocacy A champion for bio-based chemicals; an advocacy group Need to address lack of policy by direct lobbying/politics New Paradigm for IP Just equity for the licence fee Royalties possible, but not until full commercial production; no minimums Incubators Additional overhead for start-up is a non-starter today Equity, with rent payments beginning and ramping up after 24 months Grants (US) SBIR funding is great, but is US-only, and there is not enough Other FOAs allow foreign entities A vehicle for cost-sharing and the non-technical parts of the grant package

12 DODDS & ASSOCIATES © 2014 D A & “Lignin” Technical Opportunities

13 DODDS & ASSOCIATES © 2014 D A & Lignin and Hemi-cellulose Hemi-cellulose 15% (or more) of tree mass is recoverable Extracted with hot water and easily depolymerized to 5-carbon sugars Commercially valuable by-products; acetic acid, methanol, etc. Lignin ~20% of all biomass 1.3 BB tonnes renewable biomass each year in US = 260 MM tonnes lignin US consumption of BTX, phenol, PTA is ~30MM tonnes 10% efficiency across collection & conversion = ~300 MM tonnes at 10% efficiency, we are just short of total replacement of the feedstock need for major aromatic chemicals Phenylpropionic monomers hard to reach

14 DODDS & ASSOCIATES © 2014 D A & Lignin Biochemistry steps; ~70% average carbon efficiency

15 DODDS & ASSOCIATES © 2014 D A & What is the value of this molecule? (ask your chemists) R1, R2, R3 = H, OH, OCH 3 R4 = COOR, CH 2 OH Decarboxylation to styrenes Ring-opening with dioxygenases Not just woody biomass! Corn fiber contains 2-3% ferulic acid

16 DODDS & ASSOCIATES © 2014 D A & Hemi-cellulose: (not glucose, not fermentation) Just four chemical processes applied to C5 monomers All amenable to continuous petrochemical process design ….but we need some hydrogen PCT/US/14/027269

17 DODDS & ASSOCIATES © 2014 D A & Redox & Hydrogen We generally want to make molecules more reduced than carbohydrates, which occupy the center of the redox range of carbon Biological pathways can use H 2 gas, but other forms of reducing equivalents are far more common; NADH, NADPH, FMNH 2 etc. and this is generated by oxidizing carbohydrate feedstock to CO 2 This costs carbon! If we make hydrogen, we lose carbon. 3 O 2 + C 6 H 12 O 6  6 H CO 2 1 mt H 2 costs; Carbohydrate at $400/mt  $6000 Electricity at $60/MW  $3200 Methane steam cracker  ~$1800

18 DODDS & ASSOCIATES © 2014 D A & Why is Hydrogen Important? Ethanol1 glucose  2 EtOH + 2 CO 2 (50%)9 H glucose  3 EtOH Butanol 1 glucose  1 BuOH + H 2 O + 2 CO 2 (50%)6 H glucose  1.5 BuOH H2O 1,4-BDO 11/12 glucose  1 BDO H 2 O CO 2 (100%) 10 H CO glucose  2 BDO + 6 H 2 O Difficult to handle H 2 gas in a fermentor; hazardous and gas/liquid transfer Electrochemical methods to add reducing equivalents avoids this, and allows “hydrogen distribution” via existing electrical grid WO2014/ and earlier work at MSU

19 DODDS & ASSOCIATES © 2014 D A & Biocatalysis: An Overlooked Technology The use of biological catalysts - enzymes - as isolated catalysts under non- physiological conditions The last 25 years have seen there increasing use in pharma especially Rapid advances in relevant biological platform technologies Almost completely unused in chemical industry, yet can be used in standard industrial catalytic process configurations These catalysts are just high molecular weight polyamides that do not contain precious metals… …and are getting much easier to make!

20 DODDS & ASSOCIATES © 2014 D A & PublicationsCost of Sequencing Number 100k 10k Published Protein Structures Extremely Rapid Technology Growth Many public databases with complete pathways

21 DODDS & ASSOCIATES © 2014 D A & Pharma Chemical Reactions: Biocatalysis Contribution Pharma has been busy building the technology base for ~25 years Activities available in 2 weeks to 2 months; industrially relevant timing

22 DODDS & ASSOCIATES © 2014 D A & Biocatalysis Applications Immobilized Cells for Continuous Processes Catalyst containment and stability; avoids isolation & purification issues Multiple reactions possible (metabolic pathways intact, including redox) Cell-free Process Configurations  Protein engineering is available, practical and timely  Use packed-bed reactors; same as petrochemical industry  Easily scaled, stability needs to be in 6-month range  Spatial separation of multiple enzyme steps Redox Chemistry  Remains important and still difficult for chemists  Electrochemical regeneration of cofactors

23 DODDS & ASSOCIATES © 2014 D A & Our Opportunities Advocacy: a champion for bio-based chemicals policy Do what the small company cannot; actions where organizational size and membership numbers really do matter IP: New Paradigm for moving from academia to start-ups Reconsideration of Incubators and their operation A vehicle for handling the non-technical aspects of grants This has enormous value but is boring - and difficult. A practical and unified message from our community We are distracted by biofuels. We need fixed policy. We need funds that actually reach the bench rather than supporting other organizational infrastructures.

24 DODDS & ASSOCIATES © 2014 D A & David R. Dodds, Ph.D. Dodds & Associates LLC MOBILE / TWITTER drdodds4


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