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Metabolisme Asam Nukleat
Sintesis Nukleotida Purin
Pengendalian Biosintesis Purin
Salvage dari Purin Pada mamalia: –Adenin fosfo ribosiltransferase (APRT) Adenin + PRPP AMP + PPi –Hipoksantin-guanin fosforibosiltransferase (HGPRT) Hipoksantin +PRPP IMP + Ppi Guanin + PRPP GMP + Ppi Lesh-Nyhan Syndrome: –HPRT (-) –Neurologycal abnorm: –PRPP mengaktifkan Amidofosforibosil transferase (thp 2 synt IMP) Nukleotida purin asam urat
SINTESIS NUKLEOTIDA PIRIMIDIN
Toxoplasmosis Toxoplasma gondii Komplikasi: blindness, neurological dysfunction, & death in immunocompromised individuals Synthesis uracil de novo Inhibitor to carbamoyl phosphate synthetase II
Jalur Utama Katabolisme Purin
Siklus nukleotida purin
Degradasi asam urat di berbagai organisme
PURINE & PYRIMIDINE METABOLISM dr Agus Budiman. Nucleotide consists purine / pyrimidine base, ribose/deoxyribose and phosphates. Nucleotide consists purine.
Functions of Nucleotide: 1.Responsible for transmission of genetic informations 2. Act as energy currency 3.Carrier molecule for a broad spectrum of functional.
nucleotides are the activated precursors of nucleic acids. As such, they are necessary for the replication of the genome an adenine nucleotide, ATP,
Metabolism of purine nucleotides A- De Novo synthesis: of AMP and GMP Sources of the atoms in purine ring: N1: derived from NH2 group of aspartate C2 and.
NUCLEIC ACIDS METABOLISM Dr. Gamal Gabr, College of Pharmacy.
Metabolism of Purine and Pyrimidine Prof.Orhan CANBOLAT ; MD, PhD.
Purine – Lecture. Nucleotides play key roles in many, many cellular processes 1. Activated precursors of RNA and DNA 2. Adenine nucleotides are components.
Gihan E-H Gawish, MSc, PhD Ass. Professor Molecular Genetics and Clinical Biochemistry Molecular Genetics and Clinical BiochemistryKSU FIFTH WEEK.
Nucleic Acid metabolism. De Novo Synthesis of Purine Nucleotides We use for purine nucleotides the entire glycine molecule (atoms 4, 5,7), the amino nitrogen.
Nucleotide metabolism Chapter 10. Function of neucleotides Precursors for RNA and DNA synthesis Energy substance in body (ATP) Physiological Mediators.
Chapter 8. Nucleotide Metabolism Functions of nucleotites: They are precursors of DNA and RNA ATP is a universal currency of energy Physiological.
Chapter 8 Nucleotide Metabolism. Nucleotides are bilding blocks of nucleic acids. They are non-essential nutrients, because they can be synthesized in.
Metabolism of purine nucleotides 1- Biosynthesis of purine nucleoetides A- De novo biosynthesis (10 % in liver mainly) B- Salvage pathway (90 % in other.
Biosynthesis of nucleotides Natalia Tretyakova, Ph.D. Phar 6152 Spring 2004 Required reading: Stryer’s Biochemistry 5 th edition, p , (or.
Principles of Biochemistry Fourth Edition Chapter 18 Nucleotide Metabolism Copyright © 2006 Pearson Prentice Hall, Inc. Horton Moran Scrimgeour Perry Rawn.
Genetika Mikrobia Asam nukleat: bahan genetik Struktur DNA Struktur RNA Bahan genetik mikrobia Informasi genetik.
Nucleotide Metabolism Student Edition 6/3/13 version Pharm. 304 Biochemistry Fall 2014 Dr. Brad Chazotte 213 Maddox Hall Web Site:
NUCLEOTIDES AND NUCLEOSIDE BY DR. MARYJANE. INTRODUCTION Nucleotides are intracellular molecules having a sugar, base and phosphate. The base and sugar.
Purine degradation & Gout (Musculoskeletal Block).
UNIT IV: Nitrogen Metabolism Nucleotide Metabolism.
Lecture 29 Purine Metabolism/Diseases Raymond B. Birge, PhD.
BIOC/DENT/PHCY 230 LECTURE 6. Nucleotides o found in DNA and RNA o used for energy (ATP and GTP) o building blocks for coenzymes (NADH)
Phosphoribosyl Pyrophosphate (PRPP) Inosine Monophosphate (IMP) Amidophosphoribosyl -transferase (commitment step) 5-phosphoribosylamine Adenylo- succinate.
METABOLISM OF PURINE NUCLEOTIDES & PURINE DISORDERS.
Biochemistry 432/832 February 19 Chapter 27 Nucleic acid metabolism.
Zhihong Li （李志红） Department of Biochemistry Biochemistry Ⅱ.
UNIT IV: Nitrogen Metabolism Nucleotide Metabolism Part 2.
NUCLEOTIDE METABOLISM SITI ANNISA DEVI TRUSDA. Nucleotides are essential for all cells DNA/RNA synthesis protein synthesis cells proliferate Carriers.
FCH 532 Lecture 28 Chapter 28: Nucleotide metabolism Quiz on Monday essential amino acids Wed. April 11-Exam 3 ACS exam is on Monday 5/30 Final is scheduled.
Dr. S.Chakravarty, MD. A 30 year old man comes with severe pain in great toe of right foot !!
DNA Bases. Adenine: Adenine: (A) pairs with Thymine (T) only.
Salvage Pathway of Purines. Purines that result from the normal turnover of cellular nucleic acids, or that are obtained from the diet and not degraded,
Central Dogma of Biology. Nucleic Acids Are Essential For Information Transfer in Cells Information encoded in a DNA molecule is transcribed via synthesis.
Bioquímica 3e James R. Mckee Capítulo 14 Metabolismo del nitrógeno I: Síntesis.
DR. Saidunnisa M.D Associate Professor Department of Biochemistry Metabolism of Purines-Lecture.
: Nitrogen metabolism Part B Nucleotide metabolism.
What are my four bases? Adenine, Guanine, Cytosine, and Thymine.
Nucleotides, Purine Biosynthesis and Purine Catabolism.
PRPP synthetase Nucleoside phosphorylases Phosphoribosyl transferases.
Nucleic Acid Metabolism Robert F. Waters, PhD Nucleotides –Essential for all cells –Carriers of activated intermediates in carbohydrate, lipids and proteins.
Nucleic Acids Metabolism. Nitrogenous Bases Planar, aromatic, and heterocyclic Derived from purine or pyrimidine Numbering of bases is “unprimed”
Reginald H. Garrett Charles M. Grisham Chapter 26 Synthesis and Degradation of Nucleotides.
Metabolism of purines and pyrimidines Vladimíra Kvasnicová The figure was found at (Jan 2008)
Both DNA and RNA contain a series of phosphate groups and pentoses that form the backbone of their structure. Phosphate group Pentose Figure 3.25 Distinguishing.
1/03/09 De 89 à 98. 1/03/09 De 89 à 98 1/03/09 De 89 à 98.
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