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Metabolisme Asam Nukleat. Sintesis Nukleotida Purin.

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Presentation on theme: "Metabolisme Asam Nukleat. Sintesis Nukleotida Purin."— Presentation transcript:

1 Metabolisme Asam Nukleat

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4 Sintesis Nukleotida Purin

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8 Pengendalian Biosintesis Purin

9 Salvage dari Purin Pada mamalia: –Adenin fosfo ribosiltransferase (APRT) Adenin + PRPP  AMP + PPi –Hipoksantin-guanin fosforibosiltransferase (HGPRT) Hipoksantin +PRPP  IMP + Ppi Guanin + PRPP  GMP + Ppi Lesh-Nyhan Syndrome: –HPRT (-) –Neurologycal abnorm: –PRPP mengaktifkan Amidofosforibosil transferase (thp 2 synt IMP)  Nukleotida purin  asam urat

10 SINTESIS NUKLEOTIDA PIRIMIDIN

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13 Toxoplasmosis Toxoplasma gondii Komplikasi: blindness, neurological dysfunction, & death in immunocompromised individuals Synthesis uracil de novo Inhibitor to carbamoyl phosphate synthetase II

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17 DEGRADASI NUKLEOTIDA

18 Jalur Utama Katabolisme Purin

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22 Siklus nukleotida purin

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24 Degradasi asam urat di berbagai organisme

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30 DEGRADASI PIRIMIDIN

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