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Phosphoribosyl Pyrophosphate (PRPP) Inosine Monophosphate (IMP) Amidophosphoribosyl -transferase (commitment step) 5-phosphoribosylamine Adenylo- succinate.

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Presentation on theme: "Phosphoribosyl Pyrophosphate (PRPP) Inosine Monophosphate (IMP) Amidophosphoribosyl -transferase (commitment step) 5-phosphoribosylamine Adenylo- succinate."— Presentation transcript:

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2 Phosphoribosyl Pyrophosphate (PRPP) Inosine Monophosphate (IMP) Amidophosphoribosyl -transferase (commitment step) 5-phosphoribosylamine Adenylo- succinate Adenine Xanthosine Monophosphate (XMP) Guanine Xanthine Inosine Hypo- xanthine Uric Acid Adenylosuccinate synthase Adenylosuccinate lyase AMP deaminase Nucleotidase Purine Nucleosidase/Phosph orylase IMP dehydrogenase GMP reductase GMP synthase Guanase Xanthine oxido- reductase Xanthine oxoreductase Complex Pathway Pentose Phosphate Pathway

3 AMP deaminase: Missing EC , an adenosine monophosphate deaminase. Both JGI and Manatee call an adenosine deaminase with EC Guanase: Missing EC , a guanine deaminase. RAST calls a hypothetical protein with EC AT THE EXACT SAME BASE PAIRS that JGI and Manatee called an adenosine deaminase. Xanthine oxidoreductase: Missing EC or Xanthine oxoreductase: Same EC numbers as Xanthine Oxidoreductase OVERARCHING QUESTIONS: Is it an adenosine monophosphate deaminase or a guanine deaminase? What is xanthine and why does our organism appear to have no ability to do anything with it (same with other halophiles)?

4 BLAST Result for adenosine / guanine deaminase: Most were cytidine deaminases… But the second highest result was a guanine deaminase! Conclusion: Possibly a guanine deaminase?


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