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PRPP synthetase Nucleoside phosphorylases Phosphoribosyl transferases.

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Presentation on theme: "PRPP synthetase Nucleoside phosphorylases Phosphoribosyl transferases."— Presentation transcript:

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3 PRPP synthetase Nucleoside phosphorylases Phosphoribosyl transferases

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5 The committed step of de novo purine nucleotide biosynthesis

6 Phosphoribosylamine synthase: cooperativity with respect to PRPP concentration & product inhibition

7 Outline of de novo purine nucleotide biosynthesis

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13 Outline of de novo pyrimidine nucleotide biosynthesis

14 Enzymes I. Ribonucleotide reductase II. Nucleotide diphosphate kinase III. dCMP kinase IV. dUTP diphosphohydrolase V. dCMP deaminase VI. Thymidylate synthase VII. FH 2 reductase

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