3 GI tract Hollow muscular tube, lumen surrounded by 4 tissue layers: Mucosa- innermost, thin layer of smooth muscle and exocrine cells (layer that sloughs off w/ ulcerative colitis)Submucosa- connective tissueMuscularis- smooth muscleSerosa- outermost, connective tissue
4 GI tract Function: Secretion- secretes HCL acid, digestive enzymes Digestion- mechanical and chemical, food is broken down to chymeAbsorption- from GI tract to blood supplyMotilityElimination(absorbs all the minerals, w/out a GI tract you will die… stomach has pH of about 2… very acidic… if it leaks out it will cause big problems)
5 GI tractNerve SupplyIntrinsic stimulation by myenteric plexus in smooth muscle and submucosa plexus in inner layerAutonomic system- Parasympathetic stimulation by vagus nerve, connects with intrinsic systemVagus-stimulates motor and secretory activity and relaxes spinchtersSympathetic system- thoracic and lumbar splanchnic nerves slows movement, inhibits secretions and contracts spinchters(Parasympathetic slows down the GI tract… fight or flight… don’t have to go to bathroom while trying to save yourself)
7 Mouth Function: Mastication, taste, begin movement Glands produce 1 L of saliva/daySaliva contains mucin and salivary amylase with begins to break down CHOOral preparatory phase- food is softened, made into a “bolus” and tongue moves to the back of the mouthOral phase- tongue presses bolus against hard palate, elevates the larynx and forces the food bolus to the pharynx, triggering swallowing (coughing opens the flap)Pharyngeal phase- soft palate elevates and seals nasal cavity, inhibits respirations and allows esophagus to openEsophageal phase- is when bolus enter at cricopharyngeal juncture, peristalsis now takes food to the stomachAll this takes about 10 seconds !
8 EsophagusCanal about 10 in long, passes through the center of the diaphragmUpper end is the upper esophageal sphincter, at rest it is closed to prevent air from entering the esophagusLower end is the lower esophageal sphincter, it sits at the gastroesophageal junction, at rest it is closed to prevent reflux of gastric contents, this is where GERD occurs (problems w/ the LES… doesn’t shut all the way, chocolate & pepermint keeps the sphincter open, large bolus of food can keep it open… GERD)Function- to propel food and fluids and prevent refluxMucous is secreted to move the food alongCardiac sphincter of the stomach opens to allow the food to enter
9 Stomach Digestive and endocrine organ, in midline and LUQ Four regions:Cardia- narrow part that is distal to the gastroesophageal junction (part closest to the heart)Fundus- left above the GE junctionBody or corpus- largest areaAntrum- pylorus, is the distal portion and is separated from the duodenum by the pyloric sphincter, prevents backflow from the duodenum (at end)Surface is covered in rugae or folds and have smooth muscle for motilityHas intrinsic and extrinsic nerves(reglan stimulates the vagus nerve, causes contractions… gets food out of the stomack)
10 StomachFunction:Parietal cells secrete HCL acid and intrinsic factor, which absorbs B 12, without it, what anemia can occur? Pernicious anemia… makes you weak & tired… red beefy tounge, B12 injections & pill… pill not as effective… water soluble vitaminChief cells secrete Pepsinogenpepsin (breakdown enzyme)Cephalic phase- sight, smell and taste of food, regulated by vagus, begin secretory and contractile activityGastric phase- G cells in the antrum secrete gastrin, which causes HCL and pepsinogen to be released. HCL changes pepsinogen to pepsin, which digest proteins. Mucous and Bicarb (prostoglandins) are secreted to protect the stomach wall (from the acid produced)Intestinal phase- chyme produced empties into the duodenum and causes distention, this produces secretin, which stops the acid production and gastric motility !
12 Small Intestine Longest portion of the GI tract, 16-19 ft. Made up of 3 sections:Duodenum- first 12” and is attached to the pylorus. The CBD (common bile duct) and pancreatic duct join to form the ampulla of Vater and empty into the duodenum at the duodenal papilla. This surrounded by a muscle, called the Sphincter of OddiJejunum- middle 8 ft portionIleum- last 8-12 ft. The ileocecal valve separates the ileum form the cecum of the large intestineInner lining is made up of intestinal villi and folds of mucosa and submucosa for digestion.(all 3 sections for digestion)
13 Small Intestine 3 main functions: Major organ for absorption Movement- mixing and peristalsisMoves chyme by segmental contractions and mixes with enzymesDigestion- enzymes produced by the intestinal cells make:Enterokinase, peptidases, lactase, maltase and sucraseHelp to digest CHO, proteins and lipidsAbsorption- absorbs most of the nutrients from food, takes 3-10 hours for the contents to pass throughMajor organ for absorption
15 Large IntestineIleocecal valve to the anus, 5-6’, lined with columnar epithelium tha thas absorptive and mucous cells.Cecum- is the beginning, dilated pouch like structure, appendix is attached to the baseColon has 4 divisions:Ascending, transverse, descending and sigmoidRectum- last 6-8” to the sphincter muscles and anusMain function is absorption of water (problem w/ ileostomy… watery feces b/c water hasn’t been absorbed yet)
16 Large Intestine Function: Movement- segmental contractions, to allow time for the water and electrolytes to be absorbedAbsorption- absorbs most of water and electrolytes, reduces fluid volume of chyme and creates a more solid mass for eliminationElimination- 3-4 strong peristaltic contraction /day triggered by colonic distention in proximal large intestine to propel contents to rectum, until urge to defecate.
17 Nursing Assessment Family history- GI disorders, cancer Personal history- what kinds of things?Diet history- anorexia, dyspepsia- what is that? What should you question them on for diet history?Health history- diarrhea, constipation, # and color of stools, change in wt. or appetiteAbdominal pain-P- precipitatingQ-quality- how intense, severe, typeR-region or radiationS- severity scale- 0-10T-timing- when did it first occur, duration and frequency
18 Physical Assessment Abdomen: Inspection- skin, symmetry, rashes, lesions, scarsAuscultation- all four quadrants, normally heard in 5-15 seconds, normal, hypoactive or hyperactive, listen 1 full minute. What is borborygmus (very hyperactive bowel sounds)? Why would bruits be heard? (aortic) Why would there not be bowel sounds heard?Percussion- tympanic- air filled, dull- organPalpation- light and deep palpation, masses, tenderness, look for guarding (w/ appendicitis, no pain felt until you release… McMurry’s sign)
19 Lab testsCBC- anemiaOncofetal antigens- CA19-9 and CEA (carciniogenic embryonic antigen), used to monitor for cancer in the GI tractCa- decreased in malabsorptionK – decreased with vomiting, diarrhea(also decreased Magnesium can be a problem)Xylose absorption- decreased indicates possible malabsorption in the small intesting (tells if you can absorb carbs… not common & won’t ask question about)Stool for Occult bloodStool for ova and parasite- infectionStool for fecal fat- increased with Crohn’s disease and malabsorption
20 Radiology Barium enema Abdominal films- air in bowel and masses Upper GI and small bowel- pharynx to duodenojejunal junction, barium swallow and SBFTNPO 8 hours before, drink barium, then lie, stand and turn in multiple directions to view movement of bariumSBFT- drink more barium and view passageAfter drink fluids to pass barium(almost all the tests need GI prep, get rid of stool, gas & free air so when you put dye in you can see… NPO 8 hrs before test)Barium enemaLarge intestine, done for obstructions, masses, not done is perforated colon or fistulasOnly clear liquids for hours prior, NPO, given bowel prep like GolytelyInsert rectal catheter with a balloon and give ml of barium and holdCan be uncomfortable, must take a laxative after(eat or drink chalk dye)(Must get rid of the barium afterwards… prep afterwards, will turn to concrete if it stays in gut)
21 Diagnostic TestsEGD- esophagogastroduodenoscopy (what I saw in GI lab)Visualize esophagus to duodenum, NPO prior, given versed and fentanyl, maybe cetacaine to inhibit gag reflex, pass tube and visualize structures, can take biopsiesGag reflex may not return for 1-2 hours after, so no eating or drinking until then (put tounge blad in throat to see if it returned)Colonoscopy- large bowel, take biopsies and remove polyps, have a bowel prep prior, given versed and fentanyl prior; Capsule enteroscopy is now done to visualize, apply a data recorder to the abdomen and the patient swallows the capsuleProctosigmoidoscopy- like colonoscopy, only a rigid tube, less invasive and does not require the cleansing of the colonoscopy
23 Case Study72 year old male admitted with chest pain and nausea. He states that he awakens in the night with pain in his chest and nausea.What would you do first to evaluate his condition?What diseases could he have? (GERD, hiatal hernia, ulcer)What kind of lab work would you like to obtain? (cardiac enzymes, CBC, electrolytes)What past medical history do you need? (heart problems, GERD, GI bleed, what did he eat, when did he eat, drink alcohol
24 Case Study Your patient starts to have hematemesis. What does this mean? (GI bleed)Is this life-threatening? (yes, lots of elderly die from GI bleed)What interventions should be done? (give blood & normal saline, will probably have to go to surgery to fix problems… cut out part of stomach that is bleeding)What could have caused this condition? (if peritonitis, can get massive infection, mesentary is aggravated by blood & other stuff, makes stomach pull in fluid from other areas, get rigid boardlike abdomen (TEST QUESTION)
25 Case StudyIt is determined that your patient can be treated non-surgically. What medications would be given? (should have 3) Protonix, prilosec & nexium (proton pump inhibitor, stimulates parietal cells) H2 (histamine) blockers, zantac, axid & pepsic… there will be many test questions about meds on exam!!! Also give an antacid (malox, gaviscon… seep in stomach, bicab based & coat stomach & bring up pH level) Reglan can help to empty stomach (prokinetic med)What type of teaching would be done for prevention? (cut down on alcohol, smoking, no spicy foods, take zantac before you eat)If he needed surgery, what could have been done?
26 Esophageal ProblemsGERD- gastroesophageal reflux disease (most common esophageal problem… obesity… eating too much)Reflux causes esophageal mucosa to be irritated by the effects of gastric and duodenal contents, results in inflammationCauses:Inappropriate relaxation of the LES, sphincter tone is decreased (pH of 2 coming into esophagus where pH is normally much higher)Irritation from refluxed materialDelayed gastric emptying, gastric volume or intra-abdominal pressure is increasedAbnormal esophageal clearance
27 GERDRefluxed material has a pH of 1.5-2, whereas the esophagus normally has a pH of 6-8 erosive esophagitis, once inflammed, the mucosa can’t eliminate the material as quickly. This leads to increased blood flow and more erosion. Gastric acid and Pepsin cause the tissue injury.Can lead to Barrett’s epithelium- thicker, but can be cancerous, can also cause hemorrhage, aspiration pneumonia, asthma, laryngitis and dental deterioration.
29 GERD Physical Manifestations: Dyspepsia- heartburn, substernal or retrosternal burning that moves up and down in wavelike fashion, pain may radiate to neck or jaw or back, worsens when bends over, strains or lies on their back, occurs after meals and last 1-2 hours, helped by fluids (to flush, but don’t drink fluid w/ the meal… drink afterwards) and staying uprightRegurgitation- food entering throat without nausea, watch for cough (classic sign), hoarseness or wheezing (because of aspiration into lung… biggest GI complication is aspiration)Hypersalivation- water brash in response to reflux, fluid without sour or bitter taste
30 GERD Physical Manifestations Dysphagia and Odynophagia- difficulty swallowing, esophagus may be narrowed by inflammation or tumor, odynophagia- means what?Chronic cough, mostly at nightAtypical chest painBelching and flatulence or bloatingDiagnosis:Endoscopy, 24 hour ambulatory pH monitoring- pass a small tube into esophagus and monitor pH levels
31 GERD Nursing Diagnoses: Interventions: What diagnoses would apply to these patients?1. altered nutrition2. risk for dehydraion3. electrolyte imbalance4. acute pain (maybe)Interventions:Diet therapy- what type of dietary modifications would be appropriate?Certain foods decrease LES pressure- chocolate, fat and mints. Also, smoking and alcohol decreaseSpicy foods irritate the esophagus and Carbonated can increase gastric pressure
32 GERD Lifestyle changes: Drug therapy: How should they sleep? (propped up on pillows)What things increase intra-abdominal pressure? (ascites, liver failure, cancer in GI tract, obesity, pregnancy, Cushing’s, renal failure… fluid presses on stomach & gives GERD, respiratory problems)Drug therapy:Goal is to inhibit gastric acid secretion, accelerate gastric emptying and protect the gastric mucosaAntacids:Elevate the pH and deactivate pepsin, good for heartburn, take 1 hour before and 2-3 hr after a mealName 2 antacids. (malox, mylanta, gaviscon)
33 GERD Drug therapy: Histamine Receptor Antagonists Decrease acid, help promote healing of the esophagusName 2 common ones sold OTC (generic ends in “dine”)Proton Pump InhibitorsMain treatment for GERD, long acting inhibition of gastric acid secretions by inhibiting protom pump of parietal cell, can reduce by 90%/ dayName 2 proton pump inhibitors (generic ends in “zole” once a day or q 12 h at most))
34 GERDOther therapies:Consider medications that may lower LES pressure (make it worse)- oral contraceptives, anticholinergics, sedative, tranquilizers, B-adrenergic agonists, nitrates and Ca channel blockers (they all slow gut movement, then reflux occurs as food stays longer in stomach)Prokinetic drugs- for emptying and peristalsis- metoclopramide (reglan)Endoscopic:Enteryx procedure- spongy material in LES to tighten it Stretta procedure- radiofrequency energy through needles to inhibit the vagus nerveSurgical:Laparoscopic Nissen Fundoplication (main surgical procedure for GERD, takes stomach muscle up & wrap around esophagus to make it able to tighten, used a lot for hiatal hernia)Angelchik esophageal antireflux- anchors the LES in the abdomen to increase sphincter pressure (not as common)
35 Hiatal Hernia Protrusion of stomach through the esophagus Sliding or Rolling herniasSymptoms are similar to GERD patient (pain 1 to 2 hours after you eat… usually will vomit non digested food… food hasn’t even gotten into the stomach)Nonsurgical management is like GERDSurgical:Lap Nissen Fundoplication (same as GERD)- reinforces the LES, wraps a portion of the stomach around the distal esophagus to anchor itPost op- risk for bleeding (biggest risk), infection and respiratory complications (don’t want to take a deep breath b/c it hurtsHave an NGT, begin PO once BS returnWatch for gas-bloat syndrome and air swallowingMAY GET questions about when can you eat… must have bowel sounds return before eating TEST!!!
37 This is a child.***Acquired umbilical hernia may be seen if patient is 50 pounds above ideal body weight**With complaint of abd pain, nausea, vomiting and hypoactive BS consider intestinal obstruction
39 Minimally invasive commonly used **Will have an NG tube post-op—usually dark brown (old blood) for first 8 hours—just document**Keep head of bed elevated 30 degrees in the immediate post-op periodPost opSoft foods for one week, stay on antireflux meds, no driving, report fever > 101, nausea vomiting or bloating. Walk daily**otify provider if develops signs of a cold**Gas bloat is common—avoid gasy foods and eat small frequent meals.
40 Nursing Diagnosis: GERD Impaired Nutrition: less than body requirementsWhat things can be done to improve their intake and decrease pain?What would be the expected outcomes?How would you monitor their progress? (albumin to check intake)Acute Pain r/t irritation of the esophagusWhat interventions can be performed?Risk for aspiration r/t reflux of gastric contentsHow can you determine that this does not occur?
41 Peptic Ulcer Disease Mucosal lesion of the stomach or duodenum Peptic (any type of GI ulcer) can be gastric (top) or duodenal (bottom)PUD- gastric mucosal defenses become impaired and they can no longer protect the epithelium from acid and pepsinThree main types of ulcers:GastricDuodenalStress (school, life, surgery)
43 Gastric UlcersGastric mucosa is protected by mucous and bicarbonate that maintain a normal pH on the gastric tissue and protects it from acidGastromucosal prostaglandins increase the barrier’s resistance to ulceration by producing mucous (aspirin & NSAIDS inhibit prostaglandins… irritates GI)Integrity is improved by a rich blood supply to the mucosaIf there is a break in the mucosal barrier, HCL acid damages the epithelium. Gastric ulcers result from back-diffusion of acid or dysfunction of the pyloric sphincter.
44 Gastric UlcersIf the pyloric sphincter doesn’t function, bile backs up into the stomach, produces H+ ion back diffusion and mucosal inflammationToxic agents and bile destroy the lipid plasma membrane of the mucosa. Delayed gastric emptying also affects. What drug can be given to improve emptying?Gastric Ulcers are deep and penetrating and usually are in the lesser curvature of the stomach, near the pylorus(high fat & protein meals stay in stomach MUCH longer & aggravate… BRAT diet settles … bananas, rice, applesause & tea)
45 Duodenal Ulcers Occur in the first portion of the duodenum. Deep lesions that penetrate through the mucosa and submucosa into the muscle layer. The floor of the ulcer consists of a necrotic area on granulation tissue and surrounded by fibrosisHigh gastric acid secretion, pH levels are low for long periodsProtein rich meals, calcium and vagal excitation stimulate acid secretionHypersecretion, rapid emptying of food from stomach reduces the buffering effect of food and delivers a large acid bolus to the duodenumInhibitory secretory mechanisms and pancreatic secretion may be insufficient to control the acidMany patients have H. pylori infection. H. pylori produces urease changes urea to ammonia, H+ ions released contribute to damage (bacteria release hydrogen ions, greater acid levels)
47 Stress UlcersAcute gastric mucosal lesions occurring after and acute medical crisis or traumaAssociated with head injury, major surgery, burns, respiratory failure, shock and sepsisBleeding is the principle manifestationMultifocal areas often in the proximal portion of the stomach and duodenumUsually elevated HCL acid levels and hospital stay longer than 11 days(trauma, GI tract slows down, acid just sitting in stomach, causing trouble)
48 Complications of Ulcers Hemorrhage:15-25% of patients with PUD, most serious complicationMost often with gastric ulcers and elderlyAfter initial bleed, 40% have a recurrence if untreated, especially if H. pylori untreated and no H2 antagonistHave Hematemesis- bleeding at or above the duodenojejunal junctionSmaller amounts of bleeding are seen as melena (blood in stool), more often seen in duodenal ulcers, stool may appear black.
49 Complications of Ulcers Perforation (biggest complication)Gastric or duodenal may perforate or bleedStomach or duodenal contents can leak into the abdomen, acid peptic juice, bile and pancreatic juice empty through the anterior wall of the stomach into the peritoneal cavitySudden, sharp pain in midepigastric region and spread over the abdomenAmount of pain correlates with the amount and type of GI contents spilledAbdomen is tender, rigid and boardlike, go into a fetal position to decrease tension of abdomenChemical peritonitis, bacterial septicemia and hypovolemic shock follow paralytic ileus and possible death KNOW******
50 Complications of Ulcers Pyloric obstructionSmall number of patients, vomiting caused by stasis and gastric dilationObstruction occurs at the pylorus and is caused by scarring, edema, and/or inflammationGastric outlet obstruction abdominal bloating, nausea and vomiting (between pyloris & duodenum… can’t pass the food, narrowing)May go into metabolic alkalosis from loss of large quantities of acid gastric juice (H+ and Cl-)Hypokalemia may result from the vomiting
51 Complications of Ulcers Intractable diseaseDisease may recur throughout life, stressors, inability to adhere to therapy, no longer responds to managementCause:Use of NSAID’s- break down the mucosal barrier and disrupt the protection by COX inhibition. Cause the depletion of prostaglandins, have a high rate of recurrenceDrugs such as Theophylline, corticosteroids (prednisone) and caffeine stimulate HCL acid productionH pylori infection is transmitted person to person50% of people with PUD have a first or second line relative with PUD, usually the same type of ulcer
52 Physical Manifestations Epigastric tenderness, midline between the umbilicus and xiphoid processMay begin as hyperactive BS, then diminish if perforationDyspepsia- discomfort around the epigastrium, sharp, burning or gnawingGastric- occurs in upper epigastrium with localization to the left of the midline and may be relieved by food (1 to 2 hrs after eat, relieved by food that neutralizes…)Duodenal- located to the right of the epigastrium, occurs 90 min to 3 hours after eating and awaken at night, may be aggravated by spicy foods, onions, alcohol, caffeine and ASA, NSAIDS (just remember the pain will be later & more midline & to the right)
53 Physical Manifestations Vomiting may occurAppetite is maintained, unless pyloric obstruction occursFluid volume deficit, if bleeding, take orthostatic BPsWatch for Hematemesis and melenaMonitor H & HDx- barium swallow and EGDTest for H. pylori is IgG serologic testing and urea breath testing
54 Nursing Diagnoses Name 5 diagnoses r/t PUD 1. 2. 3. 4. 5. What would be an expected outcome for this disorder?
55 Nursing Interventions Drug TherapyGoals: Provide pain relief, eradicate H. pylori, heal ulcerations, prevent recurrenceEliminate H. pylori- triple treatment: TEST QUESTBismuth product (pepto-bismol, antacids to coat the stomach) or a a proton pump inhibitor (prilosec) and two antibiotics (metronidazole (Flagyl) and tetracycline or amoxicillin)May have to take medications 4 x’s/day for 14 days and often they don’t complete the series
56 Nursing Interventions Drug therapy:Hyposecretory drugs- reduce gastric acid secretionsAntisecretory agents- proton pump inhibitors, “zole” ending, suppress H, K-ATP ase enzyme system of gastric acid production, can be given IV or POH2 receptor antagonists- block histamine-stimulated gastric secretions, “dine” endingProstaglandin analogues- reduce gastric acid secretion and enhance gastric mucosal resistance to tissue injury, Misoprostol (Cytotec, coats GI tract) helps prevent NSAID induced ulcers, does cause uterine contraction and can not be given to pregnant women
57 Nursing Interventions AntacidsBuffer gastric acid and prevent formation of pepsin, heal duodenal ulcersAluminum hydroxides (may cause constipation) and magnesium hydroxide, may affect those with renal impairment (Mg causes diarrhea, malox)Take 2 hours after meals to reduce the H+ion loadCalcium carbonate (TUMS) is an antacid, but it triggers gastrin release and causes a rebound acid secretionAntacids can interact with other drugs- tetracycline, dilantin, also may have a high sodium contentMucosal Barrier fortifiers- sucralfate (Carafate) supplies a protect coating by forming a complex with proteins, binds with bile acids and pepsin, should be given on an empty stomach and not within 1 hour of eating or taking antacids
58 Nursing Interventions Diet therapyBland diet may help to relieve symptomsFood may help to neutralize acids, rebound may follow when more acid is releasedAvoid foods that stimulate gastric acid releaseThey are??Yoga for stress relief, herbals, such as licorice and vitamins may help
59 Gastrointestinal Bleeding What would be a nursing diagnosis for GI Bleeding?1. hypovolemia, anemai, altered tissue perfusion2. altered oxygenation (lack of blood), acute pain….What would be the expected outcome and how would you know that this was met?
60 Gastrointestinal Bleeding Hypovolemia ManagementMonitor vital signs and I&O, assess for bleeding and vomiting, monitor CBCFluid and electrolyte replacement is necessary, usually NSS or LR, may give PRBC’s or FFPWatch for signs of shock, what are they?? (drop in BP & elevated HR)Bleeding reductionMonitor labs, insert and NGT to decompress the stomach, give an H2 blocker, may need gastric lavage, what is that??Ice lavage, cold saline, irrigate & then suction it back out… thought to stop the bleeding in the stomach)
61 Nursing Interventions for GI bleeding Endoscopic therapyEGD, can do:cautery on the bleeding sitesinject a sclerosing agent with diluted epipherineLaser therapyClip the bleeding vesselSomastatin Analogue- Sandostatin (given IV & also used to stop diarrhea) may be used to suppress gastric acid secretion on parietal and chief cells, vasoconstricts the splanchnic arteries which reduce hemorrhage
62 Surgical management of GI bleeding MIG- minimally invasive gastrectomy- laproscopic to remove chronic gastric ulcer or treat hemorrhage, make several small incisions, may partially remove the stomach and/or vagotomy to control acid secretionGastroenterostomy- creates a passage between the body of the stomach and jejunum, reduces motor activity in the pyloroduodenal area, diverts acid, a vagotomy (cut nerves) may be done with it to decrease secretion. Can do truncal, selective or proximal. Billroth I- connect to duodenum, Billroth II connects to jejunumPyloroplasty- widens the exit of the pylorus and empties the stomach
64 Postop care for GI surgery NGT managementMonitor for complications of:Dumping syndrome- vasomotor symptoms, rapid emptying of gastric contents into the small intestine, shifts fluid into the gut and cause abdominal distention, 30 min after eating have vertigo, tachycardia, syncope, sweating, pallor, palpitations. 90 min later have excessive amount of insulin released, this dizziness, palpitations, diaphoresis and confusionShould eat smaller amounts, take less liquid with food, high protein and fat, low CHO diet, sandostatin may be given and pectin with food(Stomach doesn’t know the stomach is smaller after surgerystomach thinks there is too much sugar (high carb or high sugar) and the pancreas releases too much insluin… pt goes into hypoglycemia… diaphoretic, cold, clammy, tachycardic
65 Postop Care of GI surgery Reflux gastropathy- bile reflux, when pylorus is bypassed, bile in stomach and have abdominal discomfort and vomitingDelayed gastric emptying- usually resolves in 1 week, edema at the anastomosis or adhesions may occur, hypokalemia, hypoproteinemia and hyponatremia may also causeAfferent loop syndrome- duodenal loop is partially obstructed, pancreatic and biliary secretions fill the intestinal loop, it becomes distended painful contractions, bloating and pain min after eating (a lot of N & V after you eat… )
66 Post op GI surgeryRecurrent ulceration- occurs in 5% of patients, may have ulcers at the anastomosisNutritional management:Deficiencies of B12, folic acid and ironImpaired Ca metabolism and reduced absorption of Ca and vitamin DShortage of intrinsic factor, r/t the resection and rapid emptying of the food pernicious anemia- weak, anemic, atrophic glossitis- beefy shiny tongueGive back B12 and folic acid
68 Irritable Bowel Syndrome Chronic GI disorder, with chronic or recurrent diarrhea, constipation, abdominal pain and bloatingSpastic colon, impairment of the motor/sensory function diarrhea alternating with constipationUsually begin as a young adultStress, anxiety and familial factors may predispose patient(from spastic colon & stress… Parasympathetic is not stimulated… gut slows down… constipation with diarrhea)
69 IBS Assessment: History of bowel pattern Manning criteria- abdominal pain relieved by defection, abdominal distention, sensation of incomplete evacuation of stool, presence of mucus with the stool (don’t have to remember this)Pain in LLQ and cramps, may be tenderness and air in bowelsDx- flexible sigmoidoscopy or colonoscopy if >40Barium enema
70 IBSInterventionsDiet therapy- limit caffeine, alcohol, beverages with sorbitol (artificial sweetners), take in fiber and bulk, gm/dayDrug therapy:Bulk forming laxatives (Metamucil)antidiarrheals (loperamide, immodium, make sure they regulate how often… can cause severe constipation & dilated bowels if they take it too often)anticholinergics (bentyl, to decrease GI spasms)antidepressants (elavil)5-HT4 agonists(Zelnorm, stops GI tract pain & cramping) for prokinetic activity (allow to pass smoother), imitates serotonin to stimulate peristalsisStress management- relaxation techniques(big problem is what they eat… need more fruits & veggies, fat is bad, need more fiber
71 Nursing Diagnoses Constipation r/t low residue diet and stress What can be done to manage this?Diarrhea r/t increased motility of intestinesHow can this be corrected or treated?What can be done to correct constipation and impaction? (better to take fiber than a laxitive)What role may analgesics play in constipation?(Opiods slow down gut a lot)
72 Colorectal Cancer95% are adenocarcinomas, most come from adenomatous polyps2/3 occur in rectosigmoid regionCan metastasize through blood and lymph, liver most common site with 15-30% spread there, can also go to the lungs, brain, bones and adrenalsMay form fistulas into bladder and vaginaGenetics- autosomal dominant disorder- familial adenomatous polyposis (multiple polyps) only 1%, 100% malignant, usually starting at age 20. Also, hereditary nonpolyposis colorectal cancer- autosomal dominant, 10% of cancers, develop by age 45(colon cancer treated w/ chemo.. Major complication is diarrhea & bleeding… colon cancer, 3rd leading cause of death… spreads easily to liver, lungs-most common)
73 Colorectal cancer75% have no known cause (diet thought to have a lot to do w/ it)Age is a risk factorDietary- decreased bowel emptying time, foods with carcinogens- red meat, fatty food, fried meats and fish, concentrated sweetsHigh fat diet increases bile acid secretion and anaerobic bacteriaIrritable bowel diseases can make you more prone to colorectal cancerThird most common malignancy
74 Colorectal cancer Manifestations: Rectal bleeding, anemia and change in stoolGas pains, cramping or incomplete evacuationHematochezia- bright red blood when in rectumTumors can grow large when in upper abdomen, mostly liquid stool, more pain when in lowerTests- stool for occult blood, CEA, barium enema, CT of abdomenColonoscopy or sigmoidoscopy
75 Colorectal cancerNursing Diagnoses- Name 4 diagnoses, associated with colorectal cancer1. anxiety2. anticipatory grieving3. altered elimination, pain,4. impaired nutritionWhat would be the expected outcomes?(“this is the one that will be altered elimination & impaired nutrition”)
76 Colorectal cancer Nonsurgical management: Duke’s staging classificationA- tumor has penetrated into, but not through the bowel wallB- tumor has penetrated through the bowel wallC-tumor has penetrated through the bowel wall and there is lymph node involvementD- tumor has metastasized to distant sitesRadiation therapy (problem is it can’t be localized to gut… often have problems w/ other areas, will change normal cells & make them cancerous… leukemia later)Drug therapy- chemotherapy IV 5-FU and leucovorin, side effects are diarrhea, mucositis, leucopenia and mouth ulcers (stomatitis, affect, mouth all GI, diarrhea, N & V & bone marrow suppression)Eloxatin, Camptosar, Avastin (closes off blood vessles from tumor… finds rapidly growing cells & shuts off their blood supply) are also being used, along with monoclonal antibodies- cetuximab
77 Colorectal cancer Surgical management: Colon resection- removal of tumor and lymph nodesColectomy- colon removalAbdominal perineal resection (A & P)- removes sigmoid colon, rectum and anus, colostomy is performed (colostomy & superpubic cath for life… very invasive procedure)Colostomies may be ascending, descending, sigmoid, transverse or double barreled (if majority of colon has to be taken out..)Stool returned depends on the site of the colostomy
79 Colorectal cancer Postoperative Care: Colostomy management What types of nursing diagnoses may accompany this procedure?How should the stoma appear?Report any bleeding, breakdown of the sutures from the wall and signs of ischemia or necrosisWound care management- JP drains, monitor for infectionFluid volume deficit and electrolyte imbalance(empty bag when 1/3 to ½ full, keep it dry, w/ descending colostomy they can put a cap on it & don’t have to wear a bag all the time)
80 Colorectal cancer Teaching: Colostomy care- what kinds of things should be covered? (change bag every 7 days)Dietary measures to control stool and gas, what would they be? (no beer, broccoli, gas forming foods)Psychological adjustment to the colostomy, what diagnosis relates to this?Grief and family coping- what resources may be needed?Genetic testing if familial type
81 Intestinal Obstruction Partial or completeMechanical- bowel is physically obstructed by adhesions, tumors (food or adhesions… )Nonmechanical- paralytic ileus or adynamic ileus, neuromuscular distrubance- slow movement or backup (could be from anesthesia or narcotics)Contents accumulate at or above the obstruction distention, peristalsis increases to aid movement, stimulates more secretions more distention edema of the bowel, increased capillary permeability(metabolic alkalosis, can die from shock… too much can can make you acidotic … stomach pH)
82 Intestinal Obstruction Plasma leaks into the peritoneal cavity and trapped fluid decreases the absorption of fluid and electrolytes into the vascular space reduced blood volume and electrolyte imbalances, can hypovolemic shockCan also lead to metabolic alkalosis if high and there is a loss of gastric acid, if low, metabolic acidosis occurs with the loss of alkaline fluidsBacterial peritonitis and septic shock can also occur from the release of endotoxins
84 Intestinal Obstruction Adhesions account for 45-60%, r/t scar tissueIntussusception- telescoping bowel (slides inside itself) and volvulus- twisting of the bowelParalytic ileus (usually from meds or surgery)- decreased peristalsis from trauma, toxin or autonomic, can result from surgery, MI’s, rib fracture, pneumonia, peritonitis and vascular insufficiency from heart failure or shock
85 Intestinal Obstruction Assessment:History of symptoms and occurrenceAbdominal pain and crampingObstipation, vomiting with brown and foul smellingBorborygni above the obstruction, then absentAbdominal distention and tympanic abdomenAbdominal films and CT of abdomenWBC elevated in some cases
86 Intestinal Obstruction Nonsurgical management:NGT to decompress to LCS (remove contents)Nasointestinal tubes- Miller-Abbott, mercury balloons and migrate down the intestine by peristalsis, don’t irrigate with fluid- it will increase edema at the obstructionFluid and electrolyte replacement- NPO, give NSS or LR, replace K (always replace K)Pain control- not normally given, opioids mask pain and peritonitisAntibiotics if suspect perforationSurgical management:Exploratory laparotomy
87 Case Study24 year old female admitted with frequent bloody diarrhea stools, weight loss and anemia.What do you suspect? Colitis, crones diseaseWhat labwork should you do? CBC, platelet, chemistry K & Mg)What treatment may be needed? (diet, meds to decrease inflammation… related to some process that has cause the bowel to swell… autoimmune… allergic reaction in the gut)
88 Case StudyYour patient tells you that the diarrhea has been occurring for months.How do you differentiate between U.C. and Crohn’s disease?Colitis is the colon, crone’s disease can be anywhere in the bowel…ulcerative colitis is the sloughing of the inner layer… lots of bleeding & diarrheaPt w/ crones disease: more complications: invades all 3 or 4 layers of the gut… bouts of constipation w/ diarrhea…, can have fistula into rectum & bladder… more complications than colitisWhat may be her treatment options? Surgery to resect & possibly ostomy
89 Case Study How do you help your patient decide about a colostomy? Pt. educationIf she does want a colostomy, what type of teaching needs to be done?
90 Chronic Inflammatory Bowel Disease Ulcerative Colitis and Crohn’sUlcerative Colitis:Remissions and exacerbationsLoose stools with blood and mucous 10-20/dayPoor absorption of nutrients and thickening of the colon wallAbdominal distention and crampingComplications are: hemorrhage, perforation, fistulas and nutritional deficienciesMay be familial tendency, inflammation r/t response to normal flora
91 Chronic Inflammatory Bowel Disease Crohn’s diseaseTerminal ileum, patching involvement through all layers of the bowelDeep fissures and ulcers occur5-8 loose stools/day, rarely bloodyComplications are:Fistulas (biggest problem), nutritional deficienciesCause is thought to be mycobacterium paratuberculosis, genetic predisposition
92 Ulcerative Colitis Manifestations: Nursing Diagnoses: Abdominal pain, bloody diarrhea, tenesmus- uncontrolled strainingDx- barium enemaNursing Diagnoses:Diarrhea r/t inflammation of the bowelAcute and chronic painImbalance nutrition: less than body requirementsDisturbed body image
93 Ulcerative Colitis Diarrhea management- Drugs- salicylate compounds- Sulfasalazine (Azulfidine) inhibits prostaglandins to reduce inflammation, also use Asacol, PentasaCorticosteroids- Prednisone to decrease edemaImmunosuppressive- cyclosporineAntidiarrhealsMonoclonal antibody- Remicade neutralizes the activity of tumor necrosis factor and prevents toxic megacolon (gut stops & fills up w/ toxins… can kill you w/in matter of days)
94 Ulcerative Colitis Diet therapy: Surgical management: NPO at first, then TPN, may have low fiber or low residue, what foods would be included? (salad, raw veggies…)Surgical management:Total Proctocolectomy with permanent IleostomyTotal colectomy with a continent ileostomyTotal colectomy with ileoanal anastomosis and ileoanal reservoir or pouchPostop- teaching for ostomy, pain control and monitoring for GI bleeding and fluid volume deficit
95 A Colostomy is when only part of the large intestine is removed whereas an Ileostomy involves the removal of the whole of the large intestine and often the rectum as well. The distinguishing feature between a colostomy and an ileostomy is that in a colostomy, the stoma is made out of the large bowel and the stoma is therefore a little bigger than for an ileostomy where the stoma is made from the small intestine. Both colostomies and ileostomies can either be permanent or temporary. A Urostomy is when the bladder is bypassed or removedA Colostomy is when only part of the large intestine is removed whereas an Ileostomy involves the removal of the whole of the large intestine and often the rectum as well. The distinguishing feature between a colostomy and an ileostomy is that in a colostomy, the stoma is made out of the large bowel and the stoma is therefore a little bigger than for an ileostomy where the stoma is made from the small intestine. Both colostomies and ileostomies can either be permanent or temporary. A Urostomy is when the bladder is bypassed or removed
96 Historically, the standard operation for ulcerative colitis has been removal of the entire colon, rectum, and anus. This operation is called a proctocolectomy (Illustration A) and may be performed in one or more stages. It cures the disease and removes all risk of developing cancer in the colon or rectum. However, this operation requires creation of a Brooke ileostomy (bringing the end of the remaining bowel through the abdomen wall, Illustration B) and chronic use of an appliance on the abdominal wall to collect waste from the bowel
97 Crohn’s DiseaseAggravated by bacterial infection, inflammation and smokingHistory of fever, abdominal pain and loose stools, weight lossSteatorrhea is common- fatty stoolsFistulas may occur between bladder and vaginaDrug therapy- same as UC, except may take metronidazole (Flagyl for anaerobic bacteria in gut) if fistulas and imuran as an immunosuppressantDiet therapy- may be on TPN, supplements like ensure, vivonex
98 Crohn’s DiseaseMonitor for fistulas- infections, skin problems, malnutrition, fluid and electrolyte imbalancesFluid and electrolyte therapy- what would this entail?Name one antidiarrheal.Surgical management:Bowel resectionsFistula repairsIleostomies may also be required to rest the bowel or repair damaged areas.