1. FLUID Therapy
Dan Belz, July 2008

2. Fluid and electrolyte balance is an extremely complicated thing.

3. Importance
Need to make a decision regarding fluids in pretty much every hospitalized patient.
Can be life-saving in certain conditions
loss of body water, whether acute or chronic, can cause a range of problems from mild lightheadedness to convulsions, coma, and in some cases, death.
Though fluid therapy can be a lifesaver, it's never innocuous, and can be very harmful.

4. Kinds of IV Fluid solutions
Hypotonic - 1/2NS
Isotonic - NS, LR, albumen
Hypertonic – Hypertonic saline.
Crystalloid
Colloid

5. Crystalloid vs Colloid Type of particles (large or small)
Fluids with small “crystalizable” particles like NaCl are called crystalloids
Fluids with large particles like albumin are called colloids, these don’t (quickly) fit through vascular pores, so they stay in the circulation and much smaller amounts can be used for same volume expansion. (250ml Albumin = 4 L NS)
Edema resulting from these also tends to stick around longer for same reason.
Albumin can also trigger anaphylaxis.

6. There are two components to fluid therapy:
Maintenance therapy replaces normal ongoing losses, and
Replacement therapy corrects any existing water and electrolyte deficits.

7. Maintenance therapy
Maintenance therapy is usually undertaken when the individual is not expected to eat or drink normally for a longer time (eg, perioperatively or on a ventilator).
Big picture: Most people are “NPO” for 12 hours each day.
Patients who won’t eat for one to two weeks should be considered for parenteral or enteral nutrition.

8. Maintenance Requirements can be broken
into water and electrolyte requirements:

9. Water —
Two liters of water per day are generally sufficient for adults;
Most of this minimum intake is usually derived from the water content of food and the water of oxidation, therefore
it has been estimated that only 500ml of water needs be imbibed given normal diet and no increased losses.
These sources of water are markedly reduced in patients who are not eating and so must be replaced by maintenance fluids.

10. water requirements increase with:
water requirements increase with: fever, sweating, burns, tachypnea, surgical drains, polyuria, or ongoing significant gastrointestinal losses.
For example, water requirements increase by 100 to 150 mL/day for each C degree of body temperature elevation.

11. Several formulas can be used to calculate maintenance fluid rates.

12. A comparison of formulas produces a wide variety of fluid recommendations:
2000 cc to 3378 cc for an obese woman who is 65 inches tall and weighs 248 pounds (112.6 kg)
This is a reminder that fluid needs, no matter what formula is used, are at best an estimation.

13. 4/2/1 rule a.k.a Weight+40
I prefer the 4/2/1 rule (with a 120 mL/h limit) because it is the same as for pediatrics.

14. 4/2/1 rule 4 ml/kg/hr for first 10 kg (=40ml/hr) then 2 ml/kg/hr for next 10 kg (=20ml/hr) then 1 ml/kg/hr for any kgs over that This always gives 60ml/hr for first 20 kg then you add 1 ml/kg/hr for each kg over 20 kg
This boils down to: Weight in kg + 40 = Maintenance IV rate/hour. For any person weighing more than 20kg

15. Maintenance IV rate: 4/2/1 rule -> Weight in kg + 40

16. What to put in the fluids

17. Start: D5 1/2NS+20 meq K @ Wt+40/hr
a reasonable approach is to start 1/2 normal saline to which 20 meq of potassium chloride is added per liter. (1/2NS+20 Wt+40/hr)
Glucose in the form of dextrose (D5) can be added to provide some calories while the patient is NPO.
The normal kidney can maintain sodium and potassium balance over a wide range of intakes.
So,start:
D5 1/2NS+20 meq K
at a rate equal to their weight + 40ml/hr, but no greater than 120ml/hr.
then adjust as needed, see next page.

18. Start D5 1/2NS+20 meq K, then adjust:
If sodium falls, increase the concentration (eg, to NS)
If sodium rises, decrease the concentration (eg, 1/4NS)
If the plasma potassium starts to fall, add more potassium.
If things are good, leave things alone.

19. Usually kidneys regulate well, but: Altered homeostasis in the hospital
In the hospital, stress, pain, surgery can alter the normal mechanisms.
Increased aldosterone, Increased ADH
They generally make patients retain more water and salt, increase tendency for edema, and become hypokalemic.

24. Now onto Part 2 of the presentation:

25. Hypovolemia Hypovolemia or FVD is result of water & electrolyte loss
Compensatory mechanisms include: Increased sympathetic nervous system stimulation with an increase in heart rate & cardiac contraction; thirst; plus release of ADH & aldosterone
Severe case may result in hypovolemic shock or prolonged case may cause renal failure

26. Causes of FVD=hypovolemia:
Gastrointestinal losses: N/V/D
Renal losses: diuretics
Skin or respiratory losses: burns
Third-spacing: intestinal obstruction, pancreatitis

27. Replacement therapy.

28. A variety of disorders lead to fluid losses that deplete the extracellular fluid .
This can lead to a potentially fatal decrease in tissue perfusion.
Fortunately, early diagnosis and treatment can restore normovolemia in almost all cases.

29. There is no easy formula for assessing the degree of hypovolemia.
Hypovolemic Shock, the most severe form of hypolemia, is characterized by tachycardia, cold, clammy extremities, cyanosis, a low urine output (usually less than 15 mL/h), and agitation and confusion due to reduced cerebral blood flow.
This needs rapid treatment with isotonic fluid boluses (1-2L NS), and assessment and treatment of the underlying cause.
But hypovolemia that is less severe and therefore well compensated is more difficult to accurately assess.

30. History for assessing hypovolemia
The history can help to determine the presence and etiology of volume depletion.
Weight loss!
Early complaints include lassitude, easy fatiguability, thirst, muscle cramps, and postural dizziness.
More severe fluid loss can lead to abdominal pain, chest pain, or lethargy and confusion due to ischemia of the mesenteric, coronary, or cerebral vascular beds, respectively.
Nausea and malaise are the earliest findings of hyponatremia, and may be seen when the plasma sodium concentration falls below 125 to 130 meq/L. This may be followed by headache, lethargy, and obtundation
Muscle weakness due to hypokalemia or hyperkalemia
Polyuria and polydipsia due to hyperglycemia or severe hypokalemia
Lethargy, confusion, seizures, and coma due to hyponatremia, hypernatremia, or hyperglycemia

31. Basic signs of hypovolemia
Urine output, less than 30ml/hr
Decreased BP, Increase pulse

32. Physical exam for assessing volume
physical exam in general is not sensitive or specific
acute weight loss; however, obtaining an accurate weight over time may be difficult
decreased skin turgor - if you pinch it it stays put
dry skin, particularly axilla
dry mucus membranes
low arterial blood pressure (or relative to patient's usual BP)
orthostatic hypotension can occur with significant hypovolemia; but it is also common in euvolemic elderly subjects.
decreased intensity of both the Korotkoff sounds (when the blood pressure is being measured with a sphygmomanometer) and the radial pulse ("thready") due to peripheral vasoconstriction.
decreased Jugular Venous Pressure
The normal venous pressure is 1 to 8 cmH2O, thus, a low value alone may be normal and does not establish the diagnosis of hypovolemia.

33. SIGNS & SYMPTOMS OF Fluid Volume Excess
SOB & orthopnea
Edema & weight gain
Distended neck veins & tachycardia
Increased blood pressure
Crackles & wheezes
pleural effusion

34. For the EBM aficionados out there.
A JAMA 1999 systematic review of physical diagnosis of hypovolemia in adults
CONCLUSIONS: A large postural pulse change (> or =30 beats/min) or severe postural dizziness is required to clinically diagnose hypovolemia due to blood loss, although these findings are often absent after moderate amounts of blood loss. In patients with vomiting, diarrhea, or decreased oral intake, few findings have proven utility, and clinicians should measure serum electrolytes, serum blood urea nitrogen, and creatinine levels when diagnostic certainty is required.

35. Which brings us to: Labnormalities seen with hypovolemia
a variety of changes in urine and blood often accompany extracellular volume depletion.
In addition to confirming the presence of volume depletion, these changes may provide important clues to the etiology.

36. BUN/Cr BUN/Cr ratio normally around 10
Increase above 20 suggestive of “prerenal state”
(rise in BUN without rise in Cr called “prerenal azotemia.”)
This happens because with a low pressure head proximal to kidney, because urea (BUN) is resorbed somewhat, and creatinine is secreted somewhat as well

37. Hgb/Hct
Acute loss of EC fluid volume causes hemoconcentration (if not due to blood loss)
Acute gain of fluid will cause hemodilution of about 1g of hemoglobin (this happens very often.)

38. Plasma Na
Decrease in Intravascular volume leads to greater avidity for Na (through aldosterone) AND water (through ADH),
So overall, Plasma Na concentration tends to decrease from 140 when hypovolemia present.

39. Urine Na
Urine Na – goes down in prerenal states as body tries to hold onto water.
Getting a FENa helps correct for urine concentration.
Screwed up by lasix.
Calculator on PDA or medcalc.com

40. IV Modes of administration
Peripheral IV
PICC
Central Line
Intraosseous

41. IV Problem: Extravasation / “Infiltrated”
The most sensitive indicator of extravasated fluid or "infiltration" is to transilluminate the skin with a small penlight and look for the enhanced halo of light diffusion in the fluid filled area.
Checking flow of infusion does not tell you where the fluid is going

42. That’s it folks.