1. Monday, 22 August 2005 09:00 Welcome address Barbara Wollenberg, Nicole Rotter, Lübeck Clinical Background Chair: B. Wollenberg, R. Huss 09:10 Clinical point of view: What type of tissue do we need? Frank Riedel, Mannheim 09:25 Tracheal surgery: Clinical requirements Stephan Lang, Luebeck 09:40 Surgical reconstruction of the auricle: Clinical state of the art Konrad Sommer, Luebeck 09:55 Transplants and implants in middle ear surgery Hans-Wilhelm Pau, Rostock 10:10 Laryngeal reconstruction Georges Lawson, Yvoir 10:25Discussion Cell Sources Chair: N. Rotter, S. Tiwari 11:00 Ear chondrocytes as a source for cartilage tissue engineering in different anatomic regions Gerjo van Osch, Rotterdam 11:15 Strategies for tissue engineering of salivary glands Markus Bücheler, Bonn 11:30 Embryonic stem cell differentiation into chondrogenic cells Jürgen Rohwedel, Luebeck 11:45 Exocrine glands as a source for stem/progenitor cells Charli Kruse, Luebeck 12:00 Application of molecular imaging in stem cell tracking Robert Krieg, Siemens, Erlangen 12.15Discussion Tissue Engineering in Head and Neck Surgery (Expertissues Workshop) Biomaterials Chair: S. Lang, J. Kramer 14:00 Inflammation and immunity Pio Conti, Chieti 14:30 New Biomaterials for application in head and neck surgery Paul Hatton, Sheffield 14:50 Marine collagens – a new scaffold material Holger Notbohm, Luebeck 15:10 Polysaccharide scaffolds for bone and cartilage repair Paul Gatenholm, Chalmers 15:30Discussion Coffee break Lunch break 19:30Reception Coffee break 1. Overview of regional programs 08:30 German efforts in tissue engineering Christof Stamm, Rostock 08:50 Tissue engineering in Portugal Helena Azevedo, Braga 09:10 The baltic tissue engineering perspective Nureddin Ashammakhi, Finnland 09:30 Graduate studies in Europe Anselm Fremmer, German Research Foundation, Bonn 2. Integrating European Research Efforts 09:50 iPOOL: A digital tissue engineering platform for Europe Jürgen Beier, Augsburg 10:10 Integrating postgraduate education in TE Gustav Steinhoff, Rostock 10:30Discussion Tuesday, 23 August 2005 Coffee break Novel tissue & cell products: From bench to bedside 11:15 Clinical stem cell applications: Requirements and perspectives Ralph Huss, Munich 11:35 How a tissue engineering product gets to the patient Michael Sittinger, Berlin 11:55 GMP grade cell manipulation: The cell factory Rosaria Giordano, Milano 12:15 What does the law say? Hans-Dieter Kleine, Rostock Volker Kiefel, Rostock 12:45Discussion Clinical grade cell processing 14:00 Centralized BMC preparation Torsten Tonn, BSD Hessen 14:20 BMC preparation for cardiovascular use Wolfgang Rüdinger, Cytonet 14:40 Clinical grade cell selection Elmar Burchardt, Miltenyi Biotec 15:00 Long-term cell storage Dietmar Egger, Vita34, Leipzig 15:20 Human myoblast preparation for transplantation Maciej Kurpisz, Poznan 15:40Discussion European Education Concepts for Tissue Engineering (Joint Workshop) Lunch break Coffee break 20:00Dinner Clinical Cell Therapy for Myocardial Regeneration (Consortium Myocardial Repair Workshop) Wednesday, 24 August 2005 Stem cell mobilization in cardiology 08:00 G-CSF in acute ischemia: Is it safe? Jonathan Hill, London 08:20 The FIRST-LINE-MI study Christoph A. Nienaber, Rostock Intracoronary cell delivery 08:40 Intracoronary infusion of BMC: A multicenter trail Andreas Zeiher, Frankfurt 09:00 The BOOST study Helmut Drexler, Hannover 09:20 The IACT study Bodo Strauer, Düsseldorf 09:40 Intracoronary delivery of CD133+ cells Jozef Bartunek, Aalst 10:00 CD133+ peripheral blood vs. marrow stem cells Rosaria Giordano, Milano 10:20Discussion Do we move too fast? 16:30 Public perception of cardiac cell therapy Volker Jacobs, DGRM 17:00 Does the experimental evidence justify clinical trials? Ren Ke Li, Toronto Myoblast delivery to the heart 11:00 Myoblast transplantation: History and milestones Felipe Prosper, Pamplona 11:20 Clinical myoblast delivery methods Tomasz Siminiak, Poznan 11:40 Transendocardial myoblast delivery Hüsseyin Ince, Rostock 12:00 MAGIC-2 Study: Current status Hermann Reichenspurner, Hamburg 12:20Discussion Intramyocardial stem cell delivery 14:00 CABG & CD34+ BMSC injection Amit Patel, Pittsburgh 14:20 CABG & CD133+ BMSC injection Christof Stamm, Rostock 14:50 CABG & CD133+ PBSC injection Giulio Pompilio, Monza 15:10 TMLR and cell therapy Hans M. Klein, Düsseldorf 15:30 Mesenchymal stem cell: Is clinical use justified? Anthony D. Ho, Heidelberg 15:50Discussion Coffee break Lunch break Coffee break 16:30 Clinical cell delivery systems Warren Sherman, New York The 3rd BALTIC STEM CELL Is endorsed and sponsored by: Dear Colleagues, We cordially invite you to participate in the 3rd BALTIC STEM CELL CONFERENCE, which will take place in the beautiful and exceedingly comfortable Kempinski Grand Hotel Heiligendamm. This years conference will have two main focuses: The symposiumTissue Engineering in Head and Neck Surgery on Monday is supported by the EXPERTISSUES Network of Excellence. Advances in reconstructive head and neck surgery have revealed the vast potential of tissue engineering in otorhinolaryngology. This symposium links clinical insights in head and neck surgery with recent developments in biomaterial and stem cell technology. The following evening reception will allow participants from diverse backgrounds to exchange ideas and foster collaborations. The joint workshop on Tuesday will address educational, industrial, and legal issues that are relevant for both tissue engineering and cell therapy approaches. Clinicians, scientists, and biotech companies together will work on accelerating the bench-to- bedside process to the benefit of our patients Wednesday, the workshop Clinical Cell Therapy for Myocardial Regeneration will attempt to summarize the current clinical experience in the fast-moving field of cardiovascular cell therapy. Since numerous clinical trials are already on the way, there will certainly be enough substance for discussion. This is not to say that we have overcome the need for basic research, but to give clinicians who try to exploit the potential of regenerative therapy an opportunity to exchange their experience, to determine where they stand, and to reflect on where they want to go. The 3rd BALTIC STEM CELL CONFERENCE will be held under the auspices of the ScanBalt BioRegion network of networks. ScanBalt is funded by the Nordic Innovation Center and the European Commission and promotes the development of a globally competitive meta-bioregion. We look forward to welcoming you in Rostock-Heiligendamm! Christof StammNicole RotterTomasz Siminiak Gustav SteinhoffStephan Lang

2. Nureddin Ashammakhi, University of Tampere, Finnland Helena Azevedo, Polymer Engineering, University of Minho, Portugal Jozef Bartunek, OLV Hospital Aalst, Belgium Jürgen Beier, ICU, Augsburg, Germany Markus Bücheler, ENT Surgery, University of Bonn, Germany Elmar Burchardt, Miltenyi Biotec, Bergisch Gladbach, Germany Pio Conti, Immunology, University of Chieti, Italy Helmut Drexler, Cardiology, MHH, Hannover, Germany Dietmar Egger, Vita34, Leipzig, Germany Anselm Fremmer, DFG, Bonn, Germany Paul Gatenholm, University of Chalmers, Sweden Rosaria Giordano, Hematology, University of Milan, Italy Paul Hatton, University of Sheffield, UK Jonathan Hill, Guy's, King's and St Thomas School of Medicine, London, UK Anthony D. Ho, Hematology, University of Heidelberg, Germany Ralph Huss, Pathology, Ludwig-Maximilians University of Munich, Germany Hüsseyin Ince, Cardiology, University of Rostock, Germany Volker Jacobs, DGRM / Technical University Munich, Germany Volker Kiefel, Transfusion Medicine, University of Rostock, Germany Hans M. Klein, Cardiac Surgery, University of Düsseldorf, Germany Hans-Dieter Kleine, Hematology, University of Rostock, Germany Robert Krieg, Siemens, Erlangen, Germany Jan Kramer, Internal Medicin, University of Lübeck, Germany Charli Kruse, Medical Molecular Biology, University of Lübeck, Germany Maciej Kurpisz, Cardiology, Medical University Poznan, Poland Stephan Lang, ENT, University of Lübeck, Germany Georges Lawson, University Hospital of Louvain, Yvoir, Belgium Ren Ke Li, Cardiac Surgery, University of Toronto, Canada Markus Bücheler, ENT, University of Bonn, Germany Christoph Nienaber, Cardiology, University of Rostock, Germany Holger Notbohm, Med. Mol. Biology, University of Luebeck, Germany Gerjo van Osch, ENT Research, University of Rotterdam, Netherlands Amit Patel, Cardiac Surgery, UPMC Pittsburgh, USA Hans-Wilhelm Pau, ENT, University of Rostock, Germany Giulio Pompilio, Centro Cardiologico Monzino IRCCS, Italy Felipe Prosper Cardoso, Clínica Univ. de Navarra, Pamplona, Spain Hermann Reichenspurner, Cardiac Surgery, University of Hamburg Frank Riedel, ENT Dept., University of Mannheim, Germany Jürgen Rohwedel, Med. Mol. Biology, University of Luebeck, Germany Nicole Rotter, ENT, University of Lübeck, Germany Wolfgang Rüdinger, Cytonet, Hannover, Germany Warren Sherman, Mount Sinai Medical Center, New York City, USA Tomasz Siminiak, Cardiology, Medical University Poznan, Poland Michael Sittinger, Charité, Berlin, Germany Konrad Sommer, ENT, University of Lübeck, Germany Christof Stamm, Cardiac Surgery, University of Rostock, Germany Gustav Steinhoff, Cardiac Surgery, University of Rostock, Germany Bodo Strauer, Cardiology, University of Düsseldorf, Germany Torsten Tonn, BSD Hessen, Frankfurt, Germany Barbara Wollenberg, ENT, University of Lübeck, Germany Andreas Zeiher, Cardiology, University of Frankfurt, Germany 3 rd B ALTIC S TEM C ELL C ONFERENCE Faculty 3 rd B ALTIC S TEM C ELL C ONFERENCE University of Lübeck Medical University of Poznan University of Rostock Organized by: Dept. of Cardiac Surgery, University of Rostock ENT Dept., University of Lübeck Dept. of Cardiology, Medical University of Poznan Tissue Engineering in Head and Neck Surgery Clinical Cell Therapy for Myocardial Regeneration August 22 – 24, 2005 & Kempinski Grand Hotel Heiligendamm, Germany EUROPEAN NETWORK MYOCARDIAL REPAIR & EXPERTISSUES NETWORK OF EXCELLENCE www.kempinski-heiligendamm.com Janica Schütz Klinik und Poliklinik für Herzchirurgie Universität Rostock D-18055 Rostock Germany email: jschuetz@med.uni-rostock.de Fax: +49 381 494 6107 Phone: +49 381 494 6106 http://www.herzchirurgie-rostock.de/meetings/bssc2005 http://www.uni-luebeck/hno/meetings/bssc2005 Organizing Secretariat Venue Christof Stamm, MD Gustav Steinhoff, MD Klinik für Herzchirurgie Universität Rostock Schillingallee 35 18055 Rostock Germany christof.stamm@med.uni-rostock.de Scientific Secretariat Please be aware that the number of participants is limited! Please register prior to 14 July 2005 by mailing the enclosed postcard or by emailing the organizing secretatriat at jschuetz@med.uni-rostock.de Registration fee:for 1 day Monday 150,- Tuesday Wednesday for 2 daysMonday & Tuesday 250,- Tuesday & Wednesday for 3 daysMonday – Wednesday 350,- Reduced fee for students: 25,- per day The registration fee covers conference attendance, lunch, and reception/dinner at the Kempinski Grand Hotel Heiligendamm. Accomodation is not included Bank transfer: Baltic Stem Cell Conference Deutsche Apotheker und Ärztebank Acc/Kto: 020 580 10 79 BLZ: 100 906 03 IBAN: DE 10 300 601 01 020 580 10 79 SWIFT/BIC Code: DAAE DE DD Registration is valid once the registration fee has been received. Written requests for cancellation/refund must be received prior to 14 August 2005 and will be subject to a 50,- cancellation fee. The program may be subject to changes Registration We have reserved a limited number of rooms at special rates in several hotels. Please contact the hotel directly and mention the Baltic Stem Cell Conference. Please note that the reservation/cancellation rules of the respective hotel apply Kempinski Grand Hotel Heiligendamm ( 198,- – 284,-) +49-38203-7400 www.kempinski-heiligendamm.com Hotel Hübner, Warnemünde ( 115,- - 140,-) +49-381-54340 www.hotel-huebner.de Romantik Hotel, Bad Doberan ( 90,- - 100,-) +49-38203-63036 Aquamarin Hotel, Kühlungsborn( 60,- - 80,-) +49-38293-4020 www.hotel-aquamarin.de Accomodation Nicole Rotter, MD Stephan Lang, MD HNO Klinik Universität Lübeck Ratzeburger Allee 160 23538 Lübeck Germany Nicole.Rotter@hno.uni-luebeck.d e