1. Heavy-ion radiation decreases expression of key cellular tight junction proteins and alters microtubule dynamics in mouse intestine.
Heavy-ion radiation decreases expression of key cellular tight junction proteins and alters microtubule dynamics in mouse intestine. (A) Representative immunoblot images of cellular tight junction proteins showing radiation-induced altered expression of Occludin, Claudin1, Zo-1, and Scrib. (B) Intestinal sections were stained for Zo-1, and representative images are presented showing decreased Zo-1 after 56Fe radiation. (Scale bars, 5 μm.) (C) Intestinal sections were stained for Scrib, and a representative image for each group is presented showing decreased Scrib expression after 56Fe radiation. (Scale bars, 10 μm.) (D) Immunoblot analysis of microtubule-associated proteins was performed, and representative images are presented showing radiation-induced altered expression of Tau, phospho-Tau, Crmp2, and Map1b.
Santosh Kumar et al. PNAS 2018;115:42:E9832-E9841
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