1. Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays.
Long-term decrease of IEC migration after 56Fe radiation relative to γ-rays. (A and B) Sections of the jejunal–ilial region of mouse intestine 7 and 60 d after sham, γ-, or 56Fe radiation exposure were immunohistochemically stained for BrdU 24 h after an i.p. BrdU injection and nuclei were counterstained with hematoxylin; a representative image from each group is presented showing slower IEC migration after 56Fe radiation. (Scale bars, 10 μm.) (C) IEC migration distance was measured by counting the number of cells between the BrdU-stained top-most cell in the villus and the bottom-most cell in the crypt in 7- and 60-d postexposure samples; *, significant relative to control; **, significant relative to γ-rays. Arrows show cell migration height as well as highest labeled cell. Statistical significance is set at P < 0.05 and error bars represent mean ± SEM.
Santosh Kumar et al. PNAS 2018;115:42:E9832-E9841
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