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Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough- variant asthma and eosinophilic bronchitis in adults with chronic.

Published byAri Muljana Modified over 5 years ago

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Presentation on theme: "Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough- variant asthma and eosinophilic bronchitis in adults with chronic."— Presentation transcript:

1 Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough- variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis  Woo-Jung Song, MD, Hyun Jung Kim, MPH, PhD, Ji-Su Shim, MD, Ha-Kyeong Won, MD, Sung-Yoon Kang, MD, Kyoung-Hee Sohn, MD, Byung-Keun Kim, MD, Eun-Jung Jo, MD, Min-Hye Kim, MD, PhD, Sang-Heon Kim, MD, PhD, Heung-Woo Park, MD, PhD, Sun-Sin Kim, MD, PhD, Yoon-Seok Chang, MD, PhD, Alyn H. Morice, MD, FRCP, Byung-Jae Lee, MD, PhD, Sang-Heon Cho, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 140, Issue 3, Pages (September 2017) DOI: /j.jaci Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 PRISMA for study selection.
Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Forest plots on the diagnostic utility of Feno measurement for predicting CVA in 10 studies of patients with chronic cough (defined by cough for ≥8 weeks; A), predicting either CVA or EB in 4 studies of patients with chronic cough (B), and predicting EB in 4 studies of nonasthmatic patients with chronic cough (C). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 A, HSROC curve on the diagnostic utility of Feno measurement for predicting CVA in 10 studies of patients with chronic cough (defined by cough for ≥8 weeks). B-D, Subgroup analyses in 7 studies with a prospective design (Fig 3, B), 7 studies with guideline-based diagnostic criteria for CVA (Fig 3, C), and 6 studies that meet the diagnostic recommendations in international guidelines (using normal chest x-rays and guideline-based diagnostic criteria for CVA; Fig 3, D).5,6 The size of the circle is proportionate to the size of the study. Summary point indicates summary values for sensitivity and specificity. A 95% prediction region is the confidence region for a forecast of the true sensitivity and specificity in future studies. The HSROC curve is truncated outside of the area for which data points exist. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 HSROC curve on the diagnostic utility of Feno measurement for predicting either CVA or EB in 4 studies of patients with chronic cough. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 HSROC curve on the diagnostic utility of Feno measurement for predicting EB in 4 studies of nonasthmatic patients with chronic cough. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Fig E1A Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

8 Fig E1B Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

9 Fig E2 Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

10 Fig E3A Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

11 Fig E3B Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

12 Fig E3C Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

13 Fig E4A Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

14 Fig E4B Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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