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Hyoung Yoon Chang, MD, PhD, MPH, Dong In Suh, MD, Song-I

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Presentation on theme: "Hyoung Yoon Chang, MD, PhD, MPH, Dong In Suh, MD, Song-I"— Presentation transcript:

1 Prenatal maternal distress affects atopic dermatitis in offspring mediated by oxidative stress 
Hyoung Yoon Chang, MD, PhD, MPH, Dong In Suh, MD, Song-I. Yang, MD, PhD, Mi-Jin Kang, MS, So-Yeon Lee, MD, PhD, Eun Lee, MD, In Ae Choi, MS, Kyung-Sook Lee, PhD, Yee-Jin Shin, MD, PhD, Youn Ho Shin, MD, Yoon Hee Kim, MD, Kyung Won Kim, MD, PhD, Kangmo Ahn, MD, PhD, Hye-Sung Won, MD, PhD, Suk-Joo Choi, MD, PhD, Soo-Young Oh, MD, PhD, Ja-Young Kwon, MD, PhD, Young Han Kim, MD, PhD, Hee Jin Park, MD, PhD, Kyung-Ju Lee, MD, PhD, Jong Kwan Jun, MD, PhD, Ho-Sung Yu, MS, Seung-Hwa Lee, MS, Bok Kyoung Jung, MS, Ji-Won Kwon, MD, Yoon Kyung Choi, PhD, Namhee Do, PhD, Yun Jin Bae, PhD, Ho Kim, PhD, Woo- Sung Chang, PhD, Eun-Jin Kim, PhD, Jeom Kyu Lee, PhD, Soo-Jong Hong, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 138, Issue 2, Pages e5 (August 2016) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Cumulative hazard for a physician's diagnosis of AD in the child when the mother had prenatal depression (A) or anxiety (B) in COCOA. Values were adjusted for maternal age, educational level, delivery method, birth season, maternal history of allergic diseases, and child's sex. HR, Hazard ratio. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Relationship between prenatal maternal depression (A) and anxiety scores (B) and predicted probability of AD in COCOA. Values were adjusted for maternal age, educational level, delivery method, birth season, maternal history of allergic diseases, and child's sex. For both Fig 2, A and B, the P value was less than .001. Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Total glutathione (GSH) levels (A and C) and GSH/GSSG ratios (B and D) in the placentas of children who did or did not have AD and whose mothers were prenatally distressed or unstressed. Data are shown as means (SEs). Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Total 11β-HSD2 levels in placentas (A) and serum total IgE levels in 1-year-old children with and without AD whose mothers were prenatally distressed or unstressed (B). Data are shown as means (SEs). Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E1 Flow chart of the study participants. A, COCOA. B, PSKC.
Journal of Allergy and Clinical Immunology  , e5DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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