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The PI3K Delta Inhibitor TGR-1202 and Proteasome Inhibitor Carfilzomib Are Highly Synergistic In Killing Human B- and T-Cell Lymphoma Cells by Changchun.

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Presentation on theme: "The PI3K Delta Inhibitor TGR-1202 and Proteasome Inhibitor Carfilzomib Are Highly Synergistic In Killing Human B- and T-Cell Lymphoma Cells by Changchun."— Presentation transcript:

1 The PI3K Delta Inhibitor TGR-1202 and Proteasome Inhibitor Carfilzomib Are Highly Synergistic In Killing Human B- and T-Cell Lymphoma Cells by Changchun Deng, Christine McIntosh, Richard Rodriguez, Peter Sportelli, Hari P. Miskin, Swaroop Vakkalanka, Srikant Viswanadha, Mark Lipstein, and Owen A. O'Connor Blood Volume 122(21): November 15, 2013 ©2013 by American Society of Hematology

2 The combination of carfilzomib and TGR-1202 inhibited MCL cells in a highly synergistic manner at 24-hour of exposure. The combination of carfilzomib and TGR-1202 inhibited MCL cells in a highly synergistic manner at 24-hour of exposure. Christine McIntosh et al. Blood 2013;122:4421 ©2013 by American Society of Hematology

3 The combination of carfilzomib and TGR-1202 inhibited TCL cells in a highly synergistic manner at 48-hour of exposure. The combination of carfilzomib and TGR-1202 inhibited TCL cells in a highly synergistic manner at 48-hour of exposure. Christine McIntosh et al. Blood 2013;122:4421 ©2013 by American Society of Hematology

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