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Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma by Joshua Richter, Natalia Neparidze,

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Presentation on theme: "Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma by Joshua Richter, Natalia Neparidze,"— Presentation transcript:

1 Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma by Joshua Richter, Natalia Neparidze, Lin Zhang, Shiny Nair, Tamara Monesmith, Ranjini Sundaram, Fred Miesowicz, Kavita M. Dhodapkar, and Madhav V. Dhodapkar Blood Volume 121(3):423-430 January 17, 2013 ©2013 by American Society of Hematology

2 Study schema. Joshua Richter et al. Blood 2013;121:423-430 ©2013 by American Society of Hematology

3 Changes in NKT cells. Joshua Richter et al. Blood 2013;121:423-430 ©2013 by American Society of Hematology

4 Changes in NK cells. Joshua Richter et al. Blood 2013;121:423-430 ©2013 by American Society of Hematology

5 Changes in other innate cells and cytokines. Joshua Richter et al. Blood 2013;121:423-430 ©2013 by American Society of Hematology

6 Clinical effects of therapy. Joshua Richter et al. Blood 2013;121:423-430 ©2013 by American Society of Hematology

7 Changes in T-cell immunity. Joshua Richter et al. Blood 2013;121:423-430 ©2013 by American Society of Hematology

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