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The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition by Angela G. Fleischman, Julia.

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Presentation on theme: "The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition by Angela G. Fleischman, Julia."— Presentation transcript:

1 The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition by Angela G. Fleischman, Julia E. Maxson, Samuel B. Luty, Anupriya Agarwal, Lacey R. Royer, Melissa L. Abel, Jason D. MacManiman, Marc M. Loriaux, Brian J. Druker, and Jeffrey W. Tyner Blood Volume 122(22):3628-3631 November 21, 2013 ©2013 by American Society of Hematology

2 CSF3RT618I causes a fatal disorder reminiscent of neutrophilic leukemia. Angela G. Fleischman et al. Blood 2013;122:3628-3631 ©2013 by American Society of Hematology

3 The JAK1/2 inhibitor ruxolitinib decreases WBC count and reduces splenomegaly in CSF3RT618I mice. Angela G. Fleischman et al. Blood 2013;122:3628-3631 ©2013 by American Society of Hematology

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