1. Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells by Shannon A. Keller, Elaine J. Schattner, and Ethel Cesarman Blood Volume 96(7):2537-2542 October 1, 2000 ©2000 by American Society of Hematology

2. NF-κB is constitutively activated in KSHV-infected PEL cell lines and patient specimens.(A), Nuclear proteins extracted from latent cultures of BC1, BC2, and BC3 cells were examined by EMSA for DNA binding using a radiolabeled NF-κB–specific probe. Shannon A. Keller et al. Blood 2000;96:2537-2542 ©2000 by American Society of Hematology

3. The protein/DNA complexes in KSHV-positive PELs are primarily comprised of p65/p50 heterodimers and p50 homodimers.To assess the components of the protein/DNA complexes, nuclear proteins extracted from latent cultures of BC1, BC2, and BC3 cells were incubat... Shannon A. Keller et al. Blood 2000;96:2537-2542 ©2000 by American Society of Hematology

4. Inhibition of constitutive NF-κB activity in BC3 cells.BC3 cells placed in culture at 7.5 × 105 cells/mL were treated for 1 hour with the inhibitors SN50 (A), CAPE (B), and Bay 11-7082 (C). Shannon A. Keller et al. Blood 2000;96:2537-2542 ©2000 by American Society of Hematology

5. Specific inhibition of NF-κB with Bay 11-7082.(A), The PEL cells BC1, BC2, BC3, and control BJAB cells were treated with Bay 11 and assessed for NF-κB and Oct-1/DNA binding. Shannon A. Keller et al. Blood 2000;96:2537-2542 ©2000 by American Society of Hematology

6. Decreased cell viability and the induction of apoptosis in PEL cells treated with Bay 11.BC1, BC2, BC3, and BJAB cells were placed in culture at 7.5 × 105 cells/mL without Bay 11 or with 5 μmol/L Bay 11 for 24 hours. Shannon A. Keller et al. Blood 2000;96:2537-2542 ©2000 by American Society of Hematology