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Patterns of chronic H pylori infection with respect to acid production and pathology. Left: Acid hyposecretion. H pylori infection of the stomach body.

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Presentation on theme: "Patterns of chronic H pylori infection with respect to acid production and pathology. Left: Acid hyposecretion. H pylori infection of the stomach body."— Presentation transcript:

1 Patterns of chronic H pylori infection with respect to acid production and pathology. Left: Acid hyposecretion. H pylori infection of the stomach body causes suppression of parietal cells, low acid secretion, atrophic gastritis, intestinal metaplasia, and predisposition to gastric cancer. Right: Acid hypersecretion. H pylori infection primarily of the stomach antrum causes decreased somatostatin and increased gastrin secretion, increasing acid secretion and predisposition to duodenal ulceration. (Redrawn from Calam J et al. Pathophysiology of duodenal and gastric ulcer and gastric cancer. BMJ. 2001;323:980.) Source: Gastrointestinal Disease, Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e Citation: Hammer GD, McPhee SJ. Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e; 2013 Available at: Accessed: October 19, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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