1. Proposed model for the structure of ABC1 within the plasma membrane (modified from reference202 ). The two symmetric halves consisting of six membrane-spanning domains (enumerated with roman numerals) are shown. The two putative nucleotide-binding folds (NBF) are also shown. Bold arrows indicate the localization of defects underlying Tangier disease. Other arrows with numbers refer to amino acid residues which are bordering important structural domains.
Source: Familial Analphalipoproteinemia: Tangier Disease, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: October 16, 2017
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