1. Patterns of genetic change in neuroblastomas
Patterns of genetic change in neuroblastomas. The first row shows assessment of LOH for the short arm of chromosome 1 (1p34) using the hypervariable probe D1S57 and the enzyme TaqI. The second row shows assessment of LOH for the long arm of chromosome 14 (14p32) using the probe D14S16 and the enzyme TaqI. The third row shows assessment of MYCN amplification using the pNB-1probe and EcoRI digestion of the DNAs. The first column (patient no. 287) shows no LOH for 1p or 14q, and normal MYCN copy number. The second column (patient no. 26) shows LOH for 1p and MYCN amplification, without allelic loss for 14q. The third column (patient no. 423) shows LOH for 14q, without LOH for 1p or MYCN amplification, which was the second most common pattern of genetic change. (T = tumor DNA; N = normal DNA from the same patient). (Reprinted from Fong and colleagues75 with permission of Cancer Research.)
Source: Cancer by Site, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: October 10, 2017
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