1. THE PROSTATE

3. NORMAL PROSTATE FIBROMUSCU – LAR stroma Glands with EPITHELIUM and BASAL CELLS

4. prostate INFLAMMATION HYPERPLASIA NEOPLASIA

5. INFLAMMATION BACTERIAL, including TUBERCULOSIS IDIOPHATIC GRANULOMATOUS: The prostate becomes hard and irregular Elevated PSA Can be mistaken for cancer on palpation

7. Nodular / Adenofibromyomatous HYPERPLASIA

9. PROSTATE CANCER Almost always ADENOCARCINOMA 75 % of patients are > 75 years old Occurs in the peripheral zone Multifocal Scandinavia and the USA have the highest frequency; more common in blacks

10. How it is detected: An elevated PSA is found at urological examination ; Normal level: 4ng / ml Incidentially in TUR P material when hyperplasia is symptomatic

11. and diagnosed: Core biopsies (6 – 12 from the periphery of the prostate) Fine needle aspiration is nowadays done only to document an already known tumour

12. Prostatic Intraepithelial Neoplasia

13. PIN

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16. GLEASON GRADING

17. Gleason grade 2

18. GLEASON GRADE 3

20. Basal cells

22. GLEASON GRADE 3

23. Gleason grade 4

24. Gleson grade 5

25. Gleason grade 5

26. Perineural tumour growth