1. Male Reproductive System Kristine Krafts, M.D.

2. Male Reproductive System Outline Testis Prostate

3. Testicular Cancer The most common cancer in young men Firm, painless enlargement of the testis Seminomas and non-seminomas Curable if detected early Things you must know

4. Clinical Features of Testicular Cancer Common in men between 15-35 Firm, painless enlargement of the testis Some present with metastases Treatable – curable! - if detected early

5. Self-Exam: Look for These Things Small, painless lump Enlarged testicle Feeling of heaviness in testicle or groin Change in the way the testicle feels Accumulation of fluid

6. Testicular Cancer Classification Seminoma Non-seminoma Embryonal carcinoma Yolk sac tumor Choriocarcinoma Teratoma

7. Seminoma Half of all testicular cancers Arise from germinal epithelium of seminiferous tubules “Spermatocytic” variant occurs in older patients; better prognosis

8. Seminoma

9. Nonseminomas Embryonal tumor (undifferentiated stem cells) Yolk sac tumor (yolk sac cells) Choriocarcinoma (immature placental cells) Teratoma (somatic tissue cells)

10. Teratoma

11. Tumor markers Important for staging and follow-up. Human chorionic gonadotropin (hCG) Normally made by placental cells ↑ in choriocarcinoma; sometimes ↑ in seminoma Alpha-fetoprotein (AFP) Normally made by fetal yolk sac and other cells ↑ in yolk sac tumors and embryonal carcinoma

12. Treatment of Testicular Cancer Overall, prognosis is good If detected early, 90% cure rate 8000 new cases a year, only 400 deaths. Seminomas Often remain localized until large Metastasize locally first, then later, distantly VERY sensitive to radiation and chemotherapy Nonseminomas Metastasize earlier, farther Worse prognosis

13. Male Reproductive System Outline Testis Prostate Nodular hyperplasia Carcinoma

15. Nodular Hyperplasia Very common! Symptoms of urinary obstruction Benign proliferation of glands and stroma Caused by excessive androgens Things you must know

16. Nodular Hyperplasia Very common! 90% of men have it by their 70s. Big prostate Usually affects central zone of the prostate Symptoms (in 10% of patients): hesitancy, urgency, nocturia, poor urinary stream. Cause: excessive androgen stimulation

17. Nodular hyperplasia

19. Prostate Cancer Common, potentially deadly cancer Asymptomatic early on Develops in peripheral zones of prostate Treatment, prognosis depend on stage, grade Things you must know

20. Clinical Features of Prostate Cancer Most common, 2 nd deadliest cancer in men Peak incidence: 65-75 Cause: androgens + genetics + ?environment Symptoms: asymptomatic, then palpable nodule, then local pain/obstruction

21. Morphology of Prostate Cancer Most develop in peripheral zones of prostate Most prostate cancers are adenocarcinomas Better differentiated = better prognosis

22. Prostatic carcinoma

24. Prostate-Specific Antigen (PSA) Enzyme made by prostatic epithelial cells PSA 10 suggests cancer But PSA can go up in benign disorders too Questionable usefulness as screening test

25. Prognosis of Prostate Cancer Prognosis depends on stage (and grade) Treatment: surgery, radiation, hormonal therapy Limited disease: 90% survive 10+ years Metastatic disease: 10-40% survive 10+ years