1. ADDITIVE MANUFACTURING PROJECT CLUSTER MEETING AM for Polymers, ceramics and biomaterials Fundació CIM C/Llorens i Artigas, 12 Parc Tecnològic de Barcelona Barcelona, Spain 2 May 2016 Prof. Dr. Dirk W. Grijpma University of Twente Enschede, The Netherlands

2. RAPIDOS project description FP7-NMP-2013 EU-China Project http://rapidos-project.eu/ Partners University of Twente (NL) AO Research Institute (CH) Queen Mary University (UK) Xpand Biotechnology (NL) Shanghai Key Laboratory of Orthopaedic Implants Shenzhen Institutes of Advanced Technology Institute of Orthopaedics of Chinese People’s Liberation Army General Hospital

3. RAPIDOS project description Activity code: Biomaterials: Imaging and rapid precise prototyping technology for custom made scaffolds Aim: Custom-made bone tissue engineering constructs from resorbable polymers and calcium phosphate ceramics, by integrating imaging and information technologies, biomaterials and process engineering, biological and biomedical engineering

4. RAPIDOS Osteoinductive implants for orbital floor reconstruction

5. Stereolithography Photo-crosslinkable resin Nano-hydroxyapatite (nano-HA) Icaritin Osteoinductivity

6. RAPIDOS In vivo performance of osteoinductive implants Rabbit skull defects (ø = 6 mm) Porous implant plugs Pore size: 700 µm Porosity: 65-75 % A: empty defect B: 0 wt.% nHA C: 20 wt.% nHA D: 40 wt.% nHA 3 wks post op CT-scan

7. RAPIDOS In vivo performance of osteoinductive implants 6 wks histology

8. Exploitable results (ERs) ER1 Composite osteoinductive biomaterial suitable for AM (SLA, 3D printing) ER2 Method/process of preparing personalized patient specific medical implants.

9. > A Osteoinductive composite suitable for processing by AM > A Medical device companies B companies working in the field of AM > A Personalized implant B Osteoinductive properties C Better clinical results

10. > > Technological Readiness Level A TRL= 6-7 Milestones in the TRL progression up to TRL9 A GMP prodution and upscaling, quality control, large animal clinical trials, human trials B Market research and ensure commercial viability, specific application, start-up Main technical challenges in this result A Controlled scale-up BAM of specific material for specific application Time to market (Mth/yr): 3 yrs

11. > IPRs The University of Twente has submitted a patent application on “Artificial bone implants, or bone grafts, of polymeric composites with bone forming properties”. PCT/EP2011/068718, 26 October 2011

12. > A Method/process of preparing personalized patient specific medical implants B Imaging data is processed and used to prepare implants by AM (3d printing and stereolithography) > A Medical device companies B Companies working in the field of AM > A Personalized implants will lead to better clinical results

13. > Technological Readiness Level A TRL=6-7 Milestones in the TRL progression up to TRL9 A GMP prodution and upscaling, quality control, large animal clinical trials, human trials B Market research and ensure commercial viability, specific application, start-up Main technical challenges in this result A AM of specific material for specific application Time to market (Mth/yr): 3 yrs

14. > IPRs Have you protected or will you protect this result before disclosing it? AOF (AO Technology AG) has submitted a patent application on "Method for manufacturing an auxiliary device suitable for the manufacture of a patient customized implant“. PCT/CH 2015/000001, 12 January 2015.

15. Expressions of Interest > -Integration of different AM technologies -Improving appearance of low resolution AM -Novel materials for AM -Light-based 3D printing -Application of AM in bone and cartilage repair -Business models for AM -Skills/training in AM -Design toolkits in AM -Manufacturing of (negative) moulds by AM -Flexible manufacturing solutions