1. Inter cluster event - TTC Life sciences & Materials: Advanced Biomaterials - 13 Nov 2012

2. TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 2 Xilloc Medical B.V. Given by CEO: Maikel Beerens

3. 2003: First cranial PSI @ Maastricht UMC+ TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 3 History of Xilloc Medical B.V.

4. 2003: First cranial PSI @ Maastricht UMC+ 2006: First ever fully 3D printed cranial PSI @ MUMC+ TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 4 History of Xilloc Medical B.V. Case by: Prof Dr Poukens, Prof Dr van der Hulst – MUMC+, Maastricht, The Netherlands

5. 2003: First cranial PSI @ Maastricht UMC+ 2006: First ever fully 3D printed cranial PSI @ MUMC+ 2011: Xilloc Medical founded  Spin-off Maastricht Instruments B.V. TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 5 History of Xilloc Medical B.V.

6. TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 History of Xilloc Medical B.V. 2003: First cranial PSI @ Maastricht UMC+ 2006: First ever fully 3D printed cranial PSI @ MUMC+ 2011: Xilloc Medical founded  Spin-off MI 2011: First ever fully 3D printed jaw PSI 6

7. Founded Xilloc Medical B.V. TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 7

8. 8 About us To meet the market demand outside the MUMC+, the new company Xilloc Medical BV has been founded on the premises of Maastricht Instruments BV. The company will set out to revolutionize the implant industry with the fast and reliable production of patient-specific implants to fix bone defects in the human skeleton. Xilloc Medical will bridge the gap between surgeons and their patient-specific solutions through its innovative online ordering system and experienced team of medical and technical specialists. The company’s approach of a total implant solution will save hospitals and insurers large amounts of money, and because this procedure ensures that the implant fits all the time, every time, patients will have to undergo fewer operations. Prominent players in the field of cranio-maxillofacial reconstruction have already claimed that having patient-specific implants at their fingertips will herald a revolution.Xilloc Medical BVMaastricht Instruments BV Brief history The Maastricht University Medical Centre+ (MUMC+) has over seven years of experience in the design, manufacture and implantation of highly specialized, low-volume, patient-specific implants. Back in 2003, the Department of Cranio- Maxillofacial and Plastic Surgery of the former Maastricht University Hospital needed a product to repair large skull defects easily during surgery that not only fit the defect perfectly, but also gave an aesthetically pleasing result. Until that time, repairing large skull defects had been truly complicated by manually shaping, modeling and placing the implant. This resulted in long and complex operations with poor aesthetic results.Maastricht University Medical Centre+ In cooperation with the department of Cranio-Maxillofacial and Plastic Surgery, IDEE (the engineering department for high-tech medical instruments at the MUMC+) developed a method to preoperatively design and print 3D, patient- specific implants, based on a computer tomography scan of the patient. These have been implanted very successfully ever since.

9. A life changed… TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 9 2 bone plates removed Bike accident 2004 Bone plates removed 2004 Bone plates reimplanted 2004 Bone resorption right side 2006 Alternative reconstruction right side 2006 Bone resorption left side 2010 Reconstruction with our total patient-specific implant solution in 2010

10. 2000 fellow patients annually in EU TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 10

11. Bone cement after bone flap TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 11

12. Bone graft Bone cement Titanium mesh Moon landscape After Alternatives for reconstruction TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 12

13. Imagine how that feels… TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 13

14. Patient-specific implant TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 14

15. …A life changed TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 15

16. Us Patient-Specific Implant Outside After our product TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 16

17. Our products – Patient Specific implants TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 17

18. Our products – Anatomical Models TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 18

19. Materials PEEK Ti6Al4V PEKK TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 19

20. xilloc.com and brochure TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 20

21. “In this world of mass production we are committed to make absolutely individual pieces” TTC Lifesciences & Materials: Advanced Biomaterials - 13 Nov 2012 21

22. www.xilloc.com Maikel Beerens Xilloc Winner of: 1 1 AM Award 2012