2. Cigarette Smoking Increases the Risk Of Formation and Rupture of Intracranial Aneurysms Shelebra Bartley Master’s Project Dr. Grimes

3. If you are a woman with a brain and you smoke…

4. Your brain will EXPLODE EXPLODE

5. Quick Review An aneurysm is a weakened spot on a blood vessel that balloons out and fills with blood An aneurysm is a weakened spot on a blood vessel that balloons out and fills with blood The aneurysm can put pressure on surrounding nerves or it can rupture causing blood to spill into the surrounding tissue The aneurysm can put pressure on surrounding nerves or it can rupture causing blood to spill into the surrounding tissue

6. 3 Types of Aneurysms Fusiform Fusiform Berry Berry Lateral Lateral

7. Berry Aneurysm Aka saccular aneurysm Aka saccular aneurysm Attached by a neck or a stem to an artery Attached by a neck or a stem to an artery Accounts for 90% of all aneursyms Accounts for 90% of all aneursyms

9. Berry Aneurysm

10. How to diagnose an Aneursym? CT angiography CT angiography Magnetic Resonance Angiography (MRA) Magnetic Resonance Angiography (MRA) THE GOLD STANDARD THE GOLD STANDARD INTRA-ARTERIAL CATHETER ANGIOGRAPHY INTRA-ARTERIAL CATHETER ANGIOGRAPHY

11. CT Scan Arteriogram

12. Treatment Options REFER REFER

13. Education Stop smoking Stop smoking Stop drinking Stop drinking Control blood pressure Control blood pressure

15. Helsinki Research Results Studied 278 subjects Studied 278 subjects Age 15-60 with subarachnoid hemorrhage Age 15-60 with subarachnoid hemorrhage 314 patients in control group 314 patients in control group Research team studied the effects of cigarette smoking, alcohol intake and HTN on the rupture of intracranial aneurysms Research team studied the effects of cigarette smoking, alcohol intake and HTN on the rupture of intracranial aneurysms

16. What they found… Current cigarette smoking especially in women is an independent risk factor for formation and rupture of intracranial aneurysms Current cigarette smoking especially in women is an independent risk factor for formation and rupture of intracranial aneurysms Current smokers and previous smokers had more aneurysms than did those who had never smoked regularly Current smokers and previous smokers had more aneurysms than did those who had never smoked regularly

17. Johns Hopkins Research Angiography confirmed intracranial aneurysms Angiography confirmed intracranial aneurysms 419 patients dx with intracranial aneurysm 419 patients dx with intracranial aneurysm 127 had multiple aneurysms 127 had multiple aneurysms Women and hx of smoking Women and hx of smoking

18. Anybody need a smoke break?

19. University of Colorado 92% of patients with aneurysms larger than 24mm 92% of patients with aneurysms larger than 24mm 78% of patients with aneurysms ranging in size from 13.3mm to 24mm 78% of patients with aneurysms ranging in size from 13.3mm to 24mm 66% of patients with aneurysms smaller than 13mm 66% of patients with aneurysms smaller than 13mm

20. WERE SMOKERS

21. IN CONCLUSION Evidence has shown that cigarette smoking increases the rate of formation and rupture of intracranial aneurysms Evidence has shown that cigarette smoking increases the rate of formation and rupture of intracranial aneurysms Cigarette smoking and female gender can be identified as an independent risk factor Cigarette smoking and female gender can be identified as an independent risk factor

22. If you are a woman with a brain and you smoke…your brain will explode