1. Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10):1803-1811. doi:10.1016/j.jacc.2005.07.047 Schematic diagram of the study design. Exercise testing (X) was performed before dosing (trough), 1 h after dosing (peak), and 4 h after dosing of both fasudil and matching placebo tablets. tid = three times daily. Figure Legend:

2. Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10):1803-1811. doi:10.1016/j.jacc.2005.07.047 Patient disposition during the study. Figure Legend:

3. Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10):1803-1811. doi:10.1016/j.jacc.2005.07.047 Changes in exercise treadmill testing duration from baseline at peak for fasudil- (solid bars) and placebo-treated (open bars) patients (mean ± standard deviation). tid = three times daily. Figure Legend:

4. Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10):1803-1811. doi:10.1016/j.jacc.2005.07.047 Changes in mean time to ≥1 mm ST-segment depression from baseline for fasudil- (solid bars) and placebo-treated (open bars) patients. *p = 0.001. tid = three times daily. Figure Legend:

5. Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10):1803-1811. doi:10.1016/j.jacc.2005.07.047 Improvements in angina by ≥1 Canadian Cardiovascular Society angina class in patients treated with fasudil (solid bars) and placebo (open bars). tid = three times daily. Figure Legend:

6. Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10):1803-1811. doi:10.1016/j.jacc.2005.07.047 Improvement in Seattle Angina Questionnaire score. (A) Physical limitation scale. (B) Treatment satisfaction scale. *p < 0.05. tid = three times daily. Open bars = placebo; solid bars = fasudil. Figure Legend: