1. LECTURE 8C 1 November 2010 MINERALS MINOR MINERALS IN HEALTH AND DISEASE

2. DIGESTION, ABSORPTION AND TRANSPORT DIGESTION- NONE ABSORPTION-ACTIVE, FACILITATED AND OCCASIONALLY SIMPLE TRANSPORT-FREE – RARE- E.G. IODINE -BOUND- VERY COMMON- MOSTLY PROTEIN E.G. IODINE, IRON

3. MINERAL SUPPLEMENTS REQUIRED IF: A)INADEQUATE DIETARY SUPPLY OF MINOR MINERALS RELATIVE TO NEED B) IN DISEASE IN GENERAL, A MONITORING OF MINOR MINERALS SHOWS REQUIREMENT

4. USE OF FUNCTIONAL FOODS AND NUTRACEUTICAL TO SUPPLEMENT MINOR MINERALS EXAMPLE- BREAD

5. MINOR MINERALS IN HEALTH AND DISEASE ATHEROSCLEROSIS SELENIUM- PART OF AN ANTIOXIDANT PROTEIN ANTIOXIDANT PROTEIN REDUCES FREE RADICALS AND OXIDANT DAMAGE DUE TO FREE RADICALS R-COO.

6. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED TOOTH DECAY- FLUORIDE DEFICIENCY

7. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED FLUORIDE PREVENTS TOOTH DECAY BUT TOO MUCH FLUORIDE GIVES MOTTLED TEETH

8. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED ANEMIA-MAY BE DUE TO LACK OF IRON IN DIET

9. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED ABSORPTION VILLI

10. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED COELIAC DISEASE MALABSORPTION LACK OF IRON-GET ANEMIA

11. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED ALCOHOLISM- LOW ZINC DUE TO INCREASED URINARY OUTPUT AND MALABSORPTION OF ZINC -MALABSORPTION DUE TO POOR FAT BREAKDOWN DUE TO POOR LIVER FUNCTION.

12. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED BURNS- LOSS OF ZINC WITH ALBUMIN (ZINC IS BOUND TO ALBUMIN) IS A POSSIBLE EXPLANATION

13. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED DIABETES CHROMIUM DEFICIENT PERSONS SUPPLEMENT WITH CHROMIUM AND GET BETTER GLUCOSE TRANSPORT

14. MINOR MINERALS IN HEALTH AND DISEASE CONTINUED RHEUMATOID ARTHRITIS LOW DIETARY INTAKES OF ZINC AND SELENIUM

15. WHAT IS NEW IN MINOR MINERAL RESEARCH ? MUHOLLAND AND BEDFORD 2007 AJCN 85:318S EXCESSIVE ZINC INTAKE ( 42 MG/DAY)- INHIBITION OF COPPER ABSORPTION EXCESSIVE IODINE INTAKE (930  G/d)- -DISRUPTION OF THYROID FUNCTION

16. One final thought for today Integration of nutrients into package i.e. Macronutrient metabolism and the goods (vitamins and minerals and water to help with that Macronutrient metabolism)- please think of examples