1. Receptor-Ligand Interactions.

4. k 1 R + L  RL K -1 [RL] Ka = _____ [R] [L] Affinity constant (M -1 ) [R] [L] Kd = ______ [RL] Dissociation constant (M)

5. Common strategies used in many signaling pathways.

22. Acetylcholine muscarinic receptor of endothelial cells.

24. PIP3 or phosphatidyl 3,4,5 tri-phosphate

25. Provide binding sites for PH domain proteins.

26. PI-3Kinase and PKB/Akt pathway.

31. Ubiquitin with 7 lysine residues (K6, K11, K27, K29, K33, K48, and K63).

33. Frequently encountered signaling pathways.

40. MAPKAP Ternary Complex Factor Serum Response Factor

45. (K48)

46. (IL-1/TNF receptor Associated Kinase) (TNF receptorAssociated Factor E3 Ubiquitin Ligase) (TGFb Activated Kinase) (NFkB Inducing Kinase) (Inhibitor of kappa B Kinase)

48. TRAF6: TNF  associated factor IRAK: Il-1 R activated Kinase TAK1: TGF  Activated Kinase 1.