1. Protein kinase networks that limit TLR signalling by Kristopher Clark Biochm. Soc. Trans. Volume 42(1):11-24 February 1, 2014 ©2014 by Portland Press Ltd

2. TLR signalling pathways leading to the production of pro-inflammatory cytokines(A) MyD88- dependent signalling pathway. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

3. Negative regulation of TLR-mediated inflammation by MAPKsThe MAP3K TAK1 is at the head of the MAPK signalling cascade in response to TLR ligands (see Figure 1). Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

4. Regulation of TLR4 signalling by the PI3K pathway(A) Engagement of the TLR4 receptor at the cell surface recruits the adaptor TIRAP, and this interaction is stabilized by the association of TIRAP with PIP2 present on the inner leaf of the plasma membrane. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

5. Cross-talk within the IKK family(A) Activation of the IKKs. Recruitment of the TAK1 and canonical IKK complexes to polyubiquitin chains leads to the phosphorylation and activation of IKKα and IKKβ by TAK1. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

6. Control of anti-inflammatory cytokine production by the SIK/CRTC3 signalling cascadeTLR signalling leads to the phosphorylation of CREB at Ser133 driving the production of low levels of the anti-inflammatory cytokine IL-10. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd

7. Early Career Research Award Delivered at the University of York on 17 July 2013 at the Signalling 2013: from Structure to Function Focused MeetingKristopher Clark. Kristopher Clark Biochm. Soc. Trans. 2014;42:11-24 ©2014 by Portland Press Ltd