1. What is the problem? Our current models of disease biology are primitive and limit doctor’s understanding and ability to treat patients Current incentives reward those who silo information and work in closed systems

2. SYNAPSE CURATED DATA TOOLS/ METHODS ANALYZES/ MODELS RAW DATA BioMedical Information Commons Data Generators Data Analysts Experimentalists Clinicians Patients/ Citizens Networked Approaches 5 PRIVACY BARRIERS 5 PRIVACY BARRIERS 2 REWARDS RECOGNITION 2 REWARDS RECOGNITION 3 GOVERNANCE 3 GOVERNANCE 1 USABLE DATA 1 USABLE DATA 4 HOW TO DISTRIBUTE TASKS 4 HOW TO DISTRIBUTE TASKS

3. Synapse is GitHub for Biomedical Data Data and code versioned Analysis history captured in real time Work anywhere, and share the results with anyone Social Science Every code change versioned Every issue tracked Every project the starting point for new work All evolving and accessible in real time Social Coding

4. Breast Cancer Challenge Summary Transparency, reproducibility Transparency, reproducibility Validation in novel dataset Validation in novel dataset Publication in Science Translational Medicine Publication in Science Translational Medicine Donation of Google- scale compute space. For the goal of promoting democratization of medicine… Registration starting NOW… sign up at synapse.sagebase.org For the goal of promoting democratization of medicine… Registration starting NOW… sign up at synapse.sagebase.org 4

6. IT Pharma Academic Consortia Joint Patient/Scient ist Communities Biotech Patient Foundations Individual Patients Individual Patients Better Models of Disease: INFORMATION COMMONS Technology Platform ChallengesImpactful Models Governance Constituencies