1. TBI Alert Inventor: James Stone MD, FACS, FACNS an ICP monitor 1
Non-invasive Measurement
of Intracranial Pressure (ICP) after Traumatic Brain Injuries (TBI)
Inventor: James Stone MD, FACS, FACNS

2. The Magnitude of the Problem2
The Magnitude of the Problem
TBI Affects 1.4 Million Americans per Year
Direct and Indirect medical costs exceed $60 Billion per Year
TBI Accounts for 3% of all Injuries, but
11% of all Medical Costs
16% of all Injury Productivity Loss
Clinical Deterioration within Hours to Days after Injury due to Bleeding or Brain Swelling – Leads to Increased ICP
About 20% of Moderate TBI and 2% of Mild TBI Patients Severely Deteriorate or Die
If Detected and Treated in Time, Lives can be Saved

3. Our Invention – TBI ALERT3
Our Invention – TBI ALERT
Monitors Critical Brainstem Integrity
Conventional Treatment for Mild/Moderate TBI is only
Observation and Repeat CT Brain Scans;
Invasive ICP Monitoring Reserved for Severe TBI
Deterioration is Difficult to Timely Detect due to Patient Sedation and Altered Consciousness as well as Nurses’ Busy
TBI Alert allows Non-invasive, Continuous, Bedside ICP Monitoring for Mild/Moderate TBI, Stroke, Hydrocephalus and Tumor Patients
May Replace Need for Some Invasive ICP Procedures
in Coma Patients

4. Standard of Care vs. Our Invention
ICP Monitor
Standard of Care vs. Our Invention
Invasive ICP monitor
Our non-invasive ICP monitor

5. Comparison with Competing Devices
Monitor Brainstem Integrity
Automated Reading
Alarmed
Remote Monitoring
Continuous
Physician / Technician Not Required
For Mild/ Moderate Patients
Sensitive
Non- Invasive
Invasive ICP -
MRI
Eye
Peripheral Auditory

6. Large Market Potential6
Large Market Potential
About 250,000 Americans with TBI Hospitalized per Year
80% (200,000) Mild TBI –
2% Deteriorate/Die and 9.75% Not Working ≥ 1 year
10% (25,000) Moderate TBI –
20% Deteriorate/Die and 19% Not Working ≥ 1 year
U.S. Military in Iraq and Afghanistan - 2,882 reported TBI Cases
In the U.S., Per Year
750,000 Stroke Victims – 140,000 Die
75,000 Hydrocephalus Cases
22,500 Brain Tumors Detected – 13,000 Die