1. © 2013 Pearson Education, Inc. Chapter Opener 5

2. © 2013 Pearson Education, Inc. Figure 5.1 Skin structure. Hair shaft Epidermis Papillary layer Dermis Reticular layer Hypodermis (subcutaneous tissue; not part of skin) Dermal papillae Subpapillary plexus Sweat pore Cutaneous plexus Adipose tissue Nervous structures Sensory nerve fiber with free nerve endings Lamellar corpuscle Hair follicle receptor (root hair plexus) Appendages of skin Eccrine sweat gland Arrector pili muscle Sebaceous (oil) gland Hair follicle Hair root

3. © 2013 Pearson Education, Inc. Figure 5.2 The main structural features of the skin epidermis. Stratum spinosum Several layers of keratinocytes unified by desmosomes. Cells contain thick bundles of intermediate filaments made of pre-keratin. Stratum basale Deepest epidermal layer; one row of actively mitotic stem cells; some newly formed cells become part of the more superficial layers. See occasional melanocytes and dendritic cells. Melanocyte Dendritic cell Keratinocytes Dermis Stratum corneum Most superficial layer; 20–30 layers of dead cells, essentially flat membranous sacs filled with keratin. Glycolipids in extracellular space. Dermis Melanin granule Sensory nerve ending Tactile (Merkel) cell Desmosomes Stratum granulosum Typically five layers of flattened cells, organelles deteriorating; cytoplasm full of lamellar granules (release lipids) and keratohyaline granules.

4. © 2013 Pearson Education, Inc. Figure 5.2a The main structural features of the skin epidermis. Dermis Stratum spinosum Several layers of keratinocytes unified by desmosomes. Cells contain thick bundles of intermediate filaments made of pre-keratin. Stratum basale Deepest epidermal layer; one row of actively mitotic stem cells; some newly formed cells become part of the more superficial layers. See occasional melanocytes and dendritic cells. Stratum granulosum Typically five layers of flattened cells, organelles deteriorating; cytoplasm full of lamellar granules (release lipids) and keratohyaline granules. Stratum corneum Most superficial layer; 20–30 layers of dead cells, essentially flat membranous sacs filled with keratin. Glycolipids in extracellular space.

5. © 2013 Pearson Education, Inc. Figure 5.2b The main structural features of the skin epidermis. Stratum spinosum Several layers of keratinocytes unified by desmosomes. Cells contain thick bundles of intermediate filaments made of pre-keratin. Stratum basale Deepest epidermal layer; one row of actively mitotic stem cells; some newly formed cells become part of the more superficial layers. See occasional melanocytes and dendritic cells. Melanocyte Dendritic cell Keratinocytes Stratum corneum Most superficial layer; 20–30 layers of dead cells, essentially flat membranous sacs filled with keratin. Glycolipids in extracellular space. Dermis Melanin granule Sensory nerve ending Tactile (Merkel) cell Desmosomes Stratum granulosum Typically five layers of flattened cells, organelles deteriorating; cytoplasm full of lamellar granules (release lipids) and keratohyaline granules.

6. © 2013 Pearson Education, Inc. Figure 5.3 Light micrograph of the dermis identifying the papillary layer composed of areolar connective tissue and the reticular layer of dense irregular connective tissue (110x). Epidermis Papillary layer Dermis Reticular layer

7. © 2013 Pearson Education, Inc. Figure 5.4 Dermal modifications result in characteristic skin markings. Openings of sweat gland ducts Friction ridges Friction ridges of fingertip (SEM 12x) Cleavage lines in the reticular dermis Flexure lines of the hand Flexure lines on the palm Flexure lines on digit

8. © 2013 Pearson Education, Inc. Figure 5.4a Dermal modifications result in characteristic skin markings. Openings of sweat gland ducts Friction ridges Friction ridges of fingertip (SEM 12x)

9. © 2013 Pearson Education, Inc. Figure 5.4b Dermal modifications result in characteristic skin markings. Cleavage lines in the reticular dermis

10. © 2013 Pearson Education, Inc. Figure 5.4c Dermal modifications result in characteristic skin markings. Flexure lines of the hand Flexure lines on the palm Flexure lines on digit

11. © 2013 Pearson Education, Inc. Figure 5.5 Skin appendages: Structure of a hair and hair follicle. Follicle wall Peripheral connective tissue (fibrous) sheath Glassy membrane Epithelial root sheath External root sheath Internal root sheath Hair Cuticle Cortex Medulla Photomicrograph of a cross section of a hair and hair follicle (100x) Diagram of a cross section of a hair within its follicle Hair shaft Follicle wall Peripheral connective tissue (fibrous) sheath Glassy membrane Epithelial root sheath External root sheath Internal root sheath Hair root Cuticle Cortex Medulla Hair matrix Hair papilla Melanocyte Subcutaneous adipose tissue Photomicrograph of longitudinal view of the hair bulb in the follicle (150x) Diagram of a longitudinal view of the expanded hair bulb of the follicle, which encloses the matrix Arrector pili Sebaceous gland Hair root Hair bulb

12. © 2013 Pearson Education, Inc. Follicle wall Peripheral connective tissue (fibrous) sheath Glassy membrane Epithelial root sheath External root sheath Internal root sheath Hair Cuticle Cortex Medulla Diagram of a cross section of a hair within its follicle Hair shaft Arrector pili Hair root Hair bulb Sebaceous gland Figure 5.5a Skin appendages: Structure of a hair and hair follicle.

13. © 2013 Pearson Education, Inc. Follicle wall Peripheral connective tissue (fibrous) sheath Glassy membrane Epithelial root sheath External root sheath Internal root sheath Hair Cuticle Cortex Medulla Photomicrograph of a cross section of a hair and hair follicle (100x ) Figure 5.5b Skin appendages: Structure of a hair and hair follicle.

14. © 2013 Pearson Education, Inc. Figure 5.5c Skin appendages: Structure of a hair and hair follicle. Follicle wall Peripheral connective tissue (fibrous) sheath Glassy membrane Epithelial root sheath External root sheath Internal root sheath Hair root Cuticle Cortex Medulla Hair matrix Hair papilla Melanocyte Subcutaneous adipose tissue Diagram of a longitudinal view of the expanded hair bulb of the follicle, which encloses the matrix Hair shaft Arrector pili Sebaceous gland Hair root Hair bulb

15. © 2013 Pearson Education, Inc. Follicle wall Peripheral connective tissue (fibrous) sheath Glassy membrane Hair root Cuticle Cortex Medulla Hair matrix Hair papilla Subcutaneous adipose tissue Epithelial root sheath External root sheath Internal root sheath Photomicrograph of longitudinal view of the hair bulb in the follicle (150x) Figure 5.5d Skin appendages: Structure of a hair and hair follicle.

16. © 2013 Pearson Education, Inc. Figure 5.6 Skin appendages: Structure of a nail. Lunule Lateral nail fold Root of nail Nail matrix Proximal nail fold Eponychium (cuticle) Free edge of nail Body of nail Phalanx (bone of fingertip) Nail bed Hyponychium

17. © 2013 Pearson Education, Inc. Figure 5.7 Skin appendages: Cutaneous glands. Duct Eccrine gland Dermal connective tissue Secretory cells Sweat pore Photomicrograph of a sectioned eccrine gland (140x) Photomicrograph of a sectioned sebaceous gland (90x) Sebaceous gland Dermal connective tissue Hair in hair follicle Sebaceous gland duct

18. © 2013 Pearson Education, Inc. Figure 5.7a Skin appendages: Cutaneous glands. Dermal connective tissue Hair in hair follicle Sebaceous gland duct Sebaceous gland Eccrine gland Photomicrograph of a sectioned sebaceous gland (90x) Secretory cells Sweat pore

19. © 2013 Pearson Education, Inc. Figure 5.7b Skin appendages: Cutaneous glands. Sebaceous gland Eccrine gland Sweat pore Duct Dermal connective tissue Secretory cells Photomicrograph of a sectioned eccrine gland (140x)

20. © 2013 Pearson Education, Inc. Figure 5.8 Photographs of skin cancers. Basal cell carcinoma Squamous cell carcinoma Melanoma

21. © 2013 Pearson Education, Inc. Totals Anterior and posterior head and neck, 9% Anterior and posterior upper limbs, 18% Anterior and posterior trunk, 36% (Perineum, 1%) Anterior and posterior lower limbs, 36% 100% 41/2%41/2% 41/2%41/2%41/2%41/2% Anterior trunk, 18% 9% Figure 5.9 Estimating the extent and severity of burns using the rule of nines.

22. © 2013 Pearson Education, Inc. 1st-degree burn 2nd-degree burn Skin bearing partial thickness burn (1st- and 2nd-degree burns) Skin bearing full thickness burn (3rd-degree burn) 3rd-degree burn Figure 5.10 Partial thickness and full thickness burns.

23. © 2013 Pearson Education, Inc. System Connections 5.1