1. Chapter 12 The Central Nervous System: The Brain and Spinal Cord J.F. Thompson, Ph.D. & J.R. Schiller, Ph.D. & G. Pitts, Ph.D..

2. The Brain General 100 billion neurons about 1.6 kg in males/1.45 kg in females proportional to body size divided into hemispheres and lobes its size is not representative of intelligence complexity dictates processing power

3. Major Subdivisions of the Brain Cerebral hemispheres Diencephalon thalamus hypothalamus epithalamus Brain stem midbrain pons medulla oblongata Cerebellum

4. Distribution of Gray and White Matter Gray matter: mostly unmyelinated processes and neuron cell bodies White matter: myelinated fiber tracts cerebrum & cerebellum gray matter mostly superficial (cortex) white matter deep brain stem variable spinal cord white matter superficial gray matter deep

5. Brain Ventricles Fluid filled spaces in brain 2 lateral ventricles C-shaped chambers located deep in cerebral hemispheres connected to 3rd ventricle 3rd ventricle a slit between and inferior to the right and left halves of thalamus connects to lateral ventricles connects to 4th ventricle 4th ventricle lies between brain stem and cerebellum connects to central canal of spinal cord

6. Cerebral Hemispheres of Brain ~80% of the brain’s mass During development, gray matter grows faster than white matter gyrus - elevated ridges sulcus - shallow grooves fissure - deep grooves that separate major regions Longitudinal fissure - separates R and L hemispheres Transverse fissure - separates cortex from cerebellum

7. Cerebral Lobes (5/hemisphere) Frontal, parietal, temporal, occipital lobes Central sulcus separates frontal from parietal lobe precentral gyrus postcentral gyrus Lateral sulcus separates frontal from temporal lobe Parieto-occipital sulcus separates parietal from occipital lobe Insula: deep to portions of the temporal, parietal, and frontal lobes

8. Cerebral Cortex ~40% of brain’s mass Only 2-4 mm thick Center of consciousness Contains neuron cell bodies, dendrites, unmyelinated axons, glial cells Folds greatly increase its surface area A rich capillary blood supply is nearby

9. Cortex: General Functional Organization Three types of activity (areas) motor sensory association Each hemisphere primarily controls the opposite side of the body Although roughly equal in structure, the hemispheres are not equal in function No functional area of the brain works alone Consciousness involves all areas of the brain

10. Primary motor cortex (4*) [* Brodmann areas] precentral gyrus of frontal lobe primarily involved in voluntary motor control with more area devoted to skilled muscles (e.g., controls fingers, face) Motor Areas of the Cerebral Cortex

11. Map of the Primary Motor Cortex Motor homunculus – shows the locations on the precentral gyrus which control the skeletal muscles of each body region The “size” of the illustrated body part indicates the number of neurons dedicated to that region Control is contralateral Note: areas of specialization for communication (large size of tongue, face) and manipulation (hands)

12. Motor Areas of the Cerebral Cortex Premotor cortex Anterior to the primary motor cortex Involved in learned repetitious or patterned movements, e.g., playing a piano, typing Also important in planning movements

13. Homeostatic Imbalance of Motor Cortex Damage to the primary motor cortex effects the opposite side of body, e.g., stroke, trauma only voluntary control of skeletal muscle is lost reflexes remain -- controlled by the spinal cord Damage to the premotor cortex loss of programmed motor skills muscle strength and the ability to perform tasks remain one can still make finger movements to type, etc. not automatic need to re-learn fine motor control

14. Motor Areas of the Cerebral Cortex Language areas (Broca's area, 44, 45) only found in one hemisphere - left? a motor center for speech, controlling the muscles of the tongue, throat, and lips also involved in planning some voluntary motor activities Frontal eye field (8) - voluntary movements of eyes Broca's area

15. Sensory Areas of the Cerebral Cortex Primary somatosensory area Receives inputs directly from peripheral somatic sensory receptors Localizes points of the body where sensations originate primary areas are directly wired to the peripheral sensory receptors or motor effectors secondary areas receive input from primary areas Note:

16. Sensory Areas of the Cerebral Cortex Primary somatosensory area cutaneous sensations distribution of input areas for cutaneous sensations spatial discrimination spatial discrimination - identifies the areas of the body being stimulated MotorSensory Compare motor and sensory homunculi:

17. Somatosensory association area Gets input from primary somatosensory association area Integrates and analyzes information relative to size, texture for identification of objects Uses memories and experiences for object identification without visual input Sensory Areas of the Cerebral Cortex Posterior to the primary somatosensory area

18. Sensory Areas of the Cerebral Cortex Visual area Medial surface of occipital lobe Impulses from the eyes are routed through the thalamus

19. Sensory Areas: Visual Cortex Sensory fibers cross over to the opposite side -- 75%/25% at the optic chiasm lateral geniculate nucleus (visual area) of the thalamus occipital lobe primary sensory area association areas Processing different areas for different functions monocular vs binocular color, form, movement

20. Motion Aftereffect Pinwheel Stare directly into the center of the pinwheel for 60 seconds. Then immediately look away from the screen and at the back of your hand. Try looking at other things in the immediately vicinity as well!

21. Color Afterimage Stare directly at the center of the next screen for 60 seconds.

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24. What did you see? Let’s repeat it.

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26. + greenred yellowblue

27. Reviews of Neural Processing Different levels Neuron to neuron communication Specific hardwired pathways route information in predictable directions to specific locations Association areas permit integration and interpretation of different types of sensory information Motor areas issue appropriate commands to effector organs

28. Sensory Cortex: Auditory Area Superior part of the temporal lobe Primary auditory cortex (anterior arrow) for pitch, rhythm, loudness Auditory association area (posterior arrow) identifies/perceives sounds using memories as references

29. Sensory Cortex: Olfactory Cortex Located above the orbits and in the medial portion of the temporal lobes Conscious awareness of different smells

30. Multimodal Association Areas Anterior association area (prefrontal cortex) anterior frontal lobe intellect, complex learning, recall and personality judgement, & planning matures slowly – influenced by environment

31. Frontal Lobotomy sever the frontal lobes from the rest of the brain stops all strong emotional reactions once a popular medical/psychiatric procedure with a long history obsolete: patients had problems with planning and performing socially appropriate behaviors despite seeming to know what those behaviors would be films: Frances and One Flew Over the Cuckoo’s Nest  1500’s 1950’s 

32. Multimodal Association Areas Posterior association area Temporal, parietal and occipital lobes Pattern recognition, localizing position Receives input from motor and other sensory association areas and interprets it dropping an acid bottle (sound, sight, touch, smell, memory, learning) many sensory inputs, but the dominant feeling is of danger

33. Multimodal Association Areas Limbic association area Cingulate and parahippocampal gyri, & hippocampus Provides emotional impact and sense of danger

34. Association: Language Areas Wernicke’s area - involved in pronouncing and interpreting words Broca’s area - speech production lateral prefrontal cortex - language comprehension, word analysis lateral, ventral temporal lobe - auditory, visual aspects (naming objects, reading) the right side is more involved in body language

35. Brain Lateralization both hemispheres participate in every activity, but one hemisphere is dominant for most activities e.g.: the left hemisphere is dominant for language skills in most people (90%) the left is also dominant for math abilities and logic the right hemisphere is usually dominant for “creative” skills: visual-spatial skills intuition emotion appreciation of art and music most left-hemisphere-dominant people are right- handed

36. Brain Lateralization (or Not) Hemispheric dominance is reversed or lacking in 10% of people Most right-hemisphere-dominant people are left- handed and male Equal hemispheric function may result in ambidexterity and/or dyslexia Beware of the many “pop psychology” interpretations of the significance and meaning of hemispheric dominance

37. Cerebral White Matter Myelinated fibers provide 3 types of connections within the CNS: commissural fibers connect the hemispheres (right   left) ex: corpus callosum association fibers – connect neurons within one hemisphere projection fibers connect cerebral hemispheres to other parts of the CNS ex: internal capsule

38. Deep Cerebral Gray Matter: Basal Nuclei Diffuse masses of gray matter deep within the cerebral hemispheres Involved in regulating slow, sustained motor movements – ex: arm swinging Also inhibit unnecessary movements (stabilize and smooth primary movements) this area is affected in Parkinson’s disease results in tremors and slow, unsteady movements

39. Brain Regions: Diencephalon Composed of the thalamus, hypothalamus, and epithalamus Surrounded by the cerebral hemispheres Encloses the third ventricle

40. An egg shaped collection of nuclei serving as major “switching station” as impulses transfer from one neuron to the next Forms the lateral walls of the third ventricle Receives input from: all ascending pathways afferent impulses from all senses except smell Processes sensory information crude recognition of sensation (cerebral processing required for precise localization and conscious awareness) Thalamus (“Gateway” to the Cortex)

41. Hypothalamus (below Thalamus) Forms the bottom of the third ventricle many nuclei infundibulum – the stalk connecting the hypothalamus and pituitary gland Pituitary gland endocrine gland – “the master gland” releases its several hormones in response to chemical regulation factors from the hypothalamus

42. Functions of the Hypothalamus 1. Autonomic Nervous System (visceral) control center – important in homeostasis 2. a center for emotional responses and behaviors 3. body temperature regulation 4. regulation of food intake 5. regulation of water balance and thirst 6. regulation of sleep-wake cycles 7. controls many endocrine system functions neuroendocrine feedback control

43. Epithalamus (upon the Thalamus) Dorsal portion of the diencephalon Pineal gland (body) melatonin involved in sleep- wake cycles Location of one of the choroid plexus sites for production of cerebrospinal fluid (CSF)

44. Brain Regions: Brain Stem midbrain pons medulla Composed of the midbrain, pons and medulla Involved in automatic, unconscious behaviors needed for survival Provides pathways (fiber tracts) for neurons which are communicating up or down

45. Brain Stem: Midbrain Pons to the lower portion of the diencephalon with the cerebral aqueduct passing through it Main connecting routes for all parts of the brain and spinal cord Connections between the cerebellum and the brainstem (cerebellar peduncles)

46. Brain Stem: Pons above the medulla and anterior to the cerebellum contains both gray matter nuclei and white fibers tracts primarily conduction pathways site of origin for several cranial nerves cerebral peduncles

47. Brain Stem: Medulla Oblongata most inferior part of the brain; merges into the spinal cord inferiorly involved in maintaining internal homeostasis cardiovascular center respiratory center other centers for: vomiting hiccuping swallowing coughing sneezing

48. Brain Regions: Cerebellum Second-largest brain region (cerebellum = “small brain”) Separated from the cerebrum by the transverse fissure folia) arbor vitae Its surface is the cerebellar cortex (gray matter) with folds (folia); its white matter fiber tracts are located in the interior (arbor vitae = “tree of life”)

49. Cerebellar Structure and Function Shaped like a butterfly central vermis (“worm”) cerebellar hemispheres Functions to compare an intended movement (directed from the cortex) with what movement is actually happening Constantly receiving sensory input from muscle, tendon, and joint proprioceptors, and visual and equilibrium receptors Homunculi: maps of the functional areas arbor vitae

50. Cerebellar Structure and Function Purkinje neurons play a major role in control over the refinement of motor activities initiated by the frontal motor cortex

51. Functional Systems of the Brain Limbic System encircles the brain stem the “emotional” center different regions of gray matter, including part of the hypothalamus and the olfactory bulbs

52. Limbic System (cont.) Functions in emotional aspects of behavior related to survival Also functions with the cerebrum in memory olfactory centers are near the limbic system individuals, objects and experiences which initiate strong emotional responses or are associated with smells are committed to memory more easily Memory impairment results from damage to the limbic system Also associated with pleasure and pain electrical stimulation elicits different responses includes defensive posturing (rage); others inspire timidity

53. Brain Systems: Reticular Formation Gray matter (nuclei) distributed within the medulla, pons, and midbrain Axonal connections to many other areas of the brain Structural and functional areas sensory, integrative and motor functions receives input from higher centers for skeletal muscle actions

54. Reticular Formation Reticular Activating System functions to alert the cerebral cortex to important incoming signals filters signal “noise” = repetitive stimuli (LSD interferes with this) e.g., studying in a noisy room maintenance of consciousness and waking from sleep (sudden stimuli) sends a constant stream of information to the cortex, maintaining arousal the RAS is inhibited by sleep centers in the hypothalamus the RAS is depressed by alcohol, sleep-inducing drugs (hypnotics) and anti-anxiety drugs LSD

55. Protection of the Brain Soft tissue which needs to be protected Several different protective mechanisms scalp hair to prevent sunstroke? bones – the cranium (“brain case”) of the skull meninges three connective tissue membranes wrapping the CNS cerebrospinal fluid (CSF) a fluid “shock absorber” which cushions and nourishes the brain blood-brain barrier the physical and physiological separation of the CNS from the bloodstream

56. Functions of the Meninges Covers and protects brain and spinal cord Protect blood vessels and enclose venous sinuses Confine the cerebrospinal fluid in the subarachnoid space Form major connective tissue partitions for brain regions within skull falx cerebri, falx cerebelli, tentorium cerebelli

57. Meninges: Dura Mater Outermost layer Dense, irregular fibrous connective tissue Strong, protective wall around the brain and spinal cord (dura mater = “tough/hard mother”)

58. Meninges: Arachnoid Membrane Loose connective tissue layer deep to the dura mater Subdural space separates the arachnoid from the dura contains interstitial fluid Arachnoid villi extend into the subdural space CSF is reabsorbed back into the blood here Subarachnoid space separates arachnoid from pia mater contains CSF CSF

59. Meninges: Pia mater Deepest layer A thin, tight transparent fibrous connective tissue supporting a network of many tiny blood vessels Pia mater extends into the sulci and follows the large blood vessels into the brain Pia mater = “gentle/little mother”

60. Protection of the Brain: Cerebrospinal Fluid CSF protects against chemical & physical injury; it serves as a second circulatory system and nourishes the CNS Found in the four ventricles and subarachnoid space 80-150 ml of CSF is normal for an adult CSF composition differs slightly from plasma Clear, colorless plasma filtrate containing: H 2 O, glucose, other nutrients, proteins, lactic acid, urea cations (Na +, K +, Ca 2+, Mg 2+ ) anions (Cl -, HCO 3 - ) some lymphocytes (white blood cells) Formed by the choroid plexuses; reabsorbed by the arachnoid villi and returned to the plasma

61. Functions of Cerebrospinal Fluid Mechanical protection shock absorbing fluid the brain “floats” in this fluid Chemical protection provides a constant chemical environment the pH of the CSF is important in the control of breathing CSF composition is important for regulating cerebral blood flow Circulation for the exchange of nutrients and waste products between the blood and nervous tissue

62. Cerebrospinal Fluid: Choroid Plexuses Special capillary networks in certain places in the ventricular walls Ependymal cells Fluid from plasma passes through the ependymal cells at choroid plexuses cells have ion pumps modify CSF regulate and maintain the blood-brain barrier Protect the brain from harmful substances in the blood

63. Blood-Brain Barrier Penetration of molecules from the blood into the brain is regulated by: tight junctions between capillary cells thick basal lamina (connective tissue layer) astrocytes pressed against capillaries The barrier is a selective membrane some substances, particularly if lipid-soluble, pass easily from blood to the brain (water, glucose, O 2, CO 2, alcohol, caffeine, nicotine, heroin, most anesthetics) most charged ions do not pass easily proteins and most antibiotics do not pass at all

64. Blood-Brain Barrier Permeability is variable depending on the site choroid plexus – CSF production vomiting center in brain stem - monitors the blood for toxic molecules and poisons hypothalamus has no blood-brain barrier monitors blood composition for water balance, temperature, pH, osmolarity and many other homeostatic metabolic functions

65. Homeostatic Imbalances of the Brain Traumatic Brain Injuries concussion a blow to head the skull stops, but the brain keeps moving the brain bounces off the inside of the skull possibly, there is no visible external damage a variety of cognitive problems follow contusion breaks in small vessels, some bleeding, visible bruising effect depends on the location laceration tearing of the brain knife and gunshot wounds, other major traumas

66. Homeostatic Imbalances of the Brain Traumatic Brain Injuries (cont.) epidural or subdural or subarachnoid hemorrhage bleeding from ruptured vessels into that space a person is normal immediately after the injury, but deteriorates as the bleeding continues hemorrhage increases intracranial pressure effects vary with the location of the hematoma surgical intervention drill holes remove clots install drainage tubes subarachnoid hemorrhage

67. Homeostatic Imbalances of the Brain Cerebrovascular Accidents (CVA’s) Stroke third leading cause of death in the United States ischemia anemia caused by reduced or blocked blood flow) hemorrhages and blood clots increase intracranial pressure brain tissue dies (infarct) risk factors: high blood pressure, high cholesterol, heart disease, narrowed carotid arteries, diabetes, smoking, obesity, excessive alcohol intake Transient ischemic attack (TIA/ministroke) may last minutes flow is reduced and brain tissue suffers temporarily blood flow is re-established

68. Homeostatic Imbalances of the Brain Degenerative brain diseases Alzheimer’s disease about 11% of population over age 65, 4 million people suffer, 100,000 die annually; hereditary component widespread cognitive deficits - (short term) memory loss, shortened attention span and disorientation, loss of language skills death from secondary causes, e.g., due to being bedridden diagnosis is difficult since there is no definitive test; only after death can it be confirmed by autopsy: significant loss of neurons in specific regions abnormal proteins are deposited in brain tissue tangled nerve masses generally, the damage is limited to the cerebral cortex

69. Alzheimer’s Disease

70. Homeostatic Imbalances of Brain Degenerative brain diseases (cont.) Parkinson’s disease progressive disorder of the CNS which typically affects victims at age 60 or so cause(s) unknown; hereditary component sometimes characterized by degeneration of dopamine-releasing neurons characterized by tremor (shaking) and rigidity (continuous contraction) motor performance impaired by bradykinesia (slow motion) and hypokinesia (reduced range of motion) treatments try to increase dopamine and decrease ACh with therapeutic drugs or by experimental implantation of fetal brain cells

71. Homeostatic Imbalances of Brain Traumatic brain diseases Cerebral Palsy damage to motor areas of brain during fetal life, at birth, or during infancy, usually transient O 2 deprivation poor control and coordination of voluntary muscle activities but usually little impact on intellect irreversible, but not progressive 70% of victims appear to be mentally retarded often due to their inability to hear or speak well generally, they are more aware and understanding of their situation and surroundings than they appear Concussion, Contusion, Sudural or Subarachnoid Hemorrhage, Cerebral Edema, CVAs

72. Not Everybody is an Einstein!

73. The Spinal Cord Spinal cord is located within the vertebral column Passes through the vertebral foramina

74. Anatomy and Protection of Spinal Cord Bone of vertebral arch CSF Spinal meninges dura mater, arachnoid, pia mater meninges cover spinal cord and spinal nerves epidural space space between the dura mater and wall of the vertebral canal filled with adipose and loose connective tissue nerves exit through intervertebral foramina

75. External Spinal Cord Anatomy Roughly cylindrical but slightly flattened dorsi-ventrally From foramen magnum to second lumbar vertebra (L2) About 2 cm wide and 42-45 cm long Cervical enlargementlumbar enlargement Cervical enlargement and lumbar enlargement are conspicuous cervical enlargement - nerves for upper extremities lumbar enlargement - nerves for lower extremities

76. External Anatomy (cont.) conus medullaris Spinal cord tapers, ends in the conus medullaris between L1 and L2 Filum terminale Filum terminale (pia mater) extends from the conus to attach the spinal cord to the coccyx Some nerves exit the vertebral column below the level of their exit from the spinal cord Cauda equina Cauda equina – “horse's tail” at end of the cord are the last few pairs of spinal nerves

77. Cross-Sectional Anatomy of the Spinal Cord “H” shaped gray matter – “butterfly” surrounded by white matter Anterior median fissure Posterior medial sulcus Gray commissure forms the cross bar of the 'H' Central canal small space in middle of gray commissure extends length of spinal cord at superior end continuous with the 4th ventricle contains CSF

78. Cross-Sectional Anatomy of the Spinal Cord Anterior to the gray commissure is the anterior white commissure The gray matter of the spinal cord is divided into horns closer to front are the anterior (ventral) gray horns closer to back are the posterior (dorsal) gray horns lateral gray horns between anterior and posterior horns present only in thoracic, upper lumbar, and sacral segments gray matter also has some named nuclei dorsal lateral ventral

79. Gray Matter Anterior horn – visceral & somatic motor neurons Ventral root - efferent (motor) nerves to skeletal muscles and to the visceral organs (effectors) Posterior horn – somatic & visceral sensory neurons Dorsal root - afferent nerves from skin, skeletal muscles, connective tissues, visceral organs

80. Gray matter In Chapter 13 we will examine the basic connections in the spinal cord, such as the reflex arc The simplest connection is a two cell reflex connecting a sensory neuron directly to a motor neuron More complicated reflexes have one or more intervening interneurons

81. White Matter of the Spinal Cord Conduction tracts in the spinal cord Named by where each is coming from where each is going to

82. White Matter of the Spinal Cord Fasciculi cuneatus and gracilis - fine touch and pressure Lateral and anterior spinothalamic tracts - pain, temperature, deep pressure and coarse touch Two paths for similar functions

83. The Spinal Cord In Chapter 13 we will examine the routes and means by which the Central Nervous Connection interacts with and controls the rest of the body. Those routes form the Peripheral Nervous System.

84. End Chapter 12 Some slides of specific spinal cord tracts appear after this slide. You are not responsible for those specific tracts for the exam.

85. Specific and Posterior Spinocerebellar Tracts Specific ascending pathways within the fasciculus gracilis and fasciculus cuneatus tracts, and their continuation in the medial lemniscal tracts The posterior spinocerebellar tract

86. Nonspecific Ascending Pathway Nonspecific pathway for pain, temperature, and crude touch within the lateral spinothalamic tract

87. The Direct (Pyramidal) System Direct pathways originate with the pyramidal neurons in the precentral gyri Impulses are sent through the corticospinal tracts and synapse in the anterior horn Stimulation of anterior horn neurons activates skeletal muscles Parts of the direct pathway, called corticobulbar tracts, innervate cranial nerve nuclei The direct pathway regulates fast and fine (skilled) movements

88. Indirect (Extrapyramidal) System Includes the brain stem, motor nuclei, and all motor pathways not part of the pyramidal system This system includes the rubrospinal, vestibulospinal, reticulospinal, and tectospinal tracts These motor pathways are complex and multisynaptic, and regulate: Axial muscles that maintain balance and posture Muscles controlling coarse movements of the proximal portions of limbs Head, neck, and eye movement

89. Extrapyramidal (Multineuronal) Pathways Reticulospinal tracts – maintain balance Rubrospinal tracts – control flexor muscles Superior colliculi and tectospinal tracts mediate head movements

90. End Chapter 12