1. William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 21 Dissection of Gene Function: Mutational Analysis in Model Organisms

2. Geneticists Use Model Organisms That Are Genetically Tractable Features of Genetic Model Organisms Yeast as a Genetic Model Organism

3. Figure 21-1 Copyright © 2006 Pearson Prentice Hall, Inc. Saccharomyces cerevisiae

4. Figure 21-2 Copyright © 2006 Pearson Prentice Hall, Inc.

5. Drosophila as a Genetic Model Organism

6. Figure 21-4 Copyright © 2006 Pearson Prentice Hall, Inc.

7. Figure 21-5 Copyright © 2006 Pearson Prentice Hall, Inc.

8. The Mouse as a Genetic Model Organism

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10. Geneticists Dissect Gene Function Using Mutations and Forward Genetics Generating Mutants with Radiation, Chemicals, and Transposon Insertion Screening for Mutants

11. Figure 21-7 Copyright © 2006 Pearson Prentice Hall, Inc.

12. Figure 21-8 Copyright © 2006 Pearson Prentice Hall, Inc.

13. Selecting for Mutants Defining the Genes (how many?)

14. Figure 21-9 Copyright © 2006 Pearson Prentice Hall, Inc.

15. Dissecting Genetic Networks: Epistasis and Pathways

16. Figure 21-10 Copyright © 2006 Pearson Prentice Hall, Inc.

17. Extending the Analysis: Suppressors and Enhancers

18. Figure 21-11 Copyright © 2006 Pearson Prentice Hall, Inc.

19. Extending the Analysis: Cloning the Genes Extending the Analysis: Biochemical Functions

20. Geneticists Dissect Gene Function Using Genomics and Reverse Genetics Genetic Analysis Beginning with a Purified Protein

21. Figure 21-12 Copyright © 2006 Pearson Prentice Hall, Inc.

22. Figure 19-21 Copyright © 2006 Pearson Prentice Hall, Inc.

23. Figure 21-13 Copyright © 2006 Pearson Prentice Hall, Inc.

24. Genetic Analysis Beginning with a Mutant Model Organism Genetic Analysis Beginning with the Cloned Gene (functional complementation)

25. Figure 21-14 Copyright © 2006 Pearson Prentice Hall, Inc.

26. Figure 21-15 Copyright © 2006 Pearson Prentice Hall, Inc.

27. Figure 21-16 Copyright © 2006 Pearson Prentice Hall, Inc.

28. Geneticists Dissect Gene Function Using Genomics and Reverse Genetics Genetic Analysis Using Gene Targeting Technologies

29. Figure 21-17 Copyright © 2006 Pearson Prentice Hall, Inc.

30. Figure 21-18 Copyright © 2006 Pearson Prentice Hall, Inc.

31. Figure 21-18a Copyright © 2006 Pearson Prentice Hall, Inc.

32. Figure 21-18b Copyright © 2006 Pearson Prentice Hall, Inc.

33. Figure 21-19 Copyright © 2006 Pearson Prentice Hall, Inc.

34. Geneticists Dissect Gene Function Using Functional Genomic and RNAi Technologies RNAi: Genetics without Mutations

35. Figure 21-20 Copyright © 2006 Pearson Prentice Hall, Inc.

36. High-Throughput Functional Genomics Techniques Gene Expression Microarrays Genome-Wide Mapping of Protein–DNA Binding Sites

37. Figure 21-21 Copyright © 2006 Pearson Prentice Hall, Inc.

38. Geneticists Advance Our Understanding of Molecular Processes by Undertaking Genetic Research in Model Organisms: Three Case Studies Yeast: Cell Cycle Genes Drosophila: The Heidelberg Screens The Mouse: A Model for ALS Gene Therapy

39. Figure 21-22 Copyright © 2006 Pearson Prentice Hall, Inc.

40. 21.5Geneticists Advance Our Understanding of Molecular Processes by Undertaking Genetic Research in Model Organisms: Three Case Studies 21.5.2 Drosophila: The Heidelberg Screens

41. Figure 21-26 Copyright © 2006 Pearson Prentice Hall, Inc.

42. 21.5Geneticists Advance Our Understanding of Molecular Processes by Undertaking Genetic Research in Model Organisms: Three Case Studies 21.5.3 The Mouse: A Model for ALS Gene Therapy

43. Figure 21-29 Copyright © 2006 Pearson Prentice Hall, Inc.