1. William S. Klug Michael R. Cummings Charlotte A. Spencer Concepts of Genetics Eighth Edition Chapter 10 DNA Structure and Analysis Copyright © 2006 Pearson Prentice Hall, Inc.

2. The Genetic Material Must Exhibit Four Characteristics Replication Storage of information Expressison of information Variation by mutation

3. Figure 10-1 Copyright © 2006 Pearson Prentice Hall, Inc.

4. Until 1944, Observations Favored Protein as the Genetic Material

5. Figure 10-2 Copyright © 2006 Pearson Prentice Hall, Inc.

6. Evidence Favoring DNA as the Genetic Material Was First Obtained during the Study of Bacteria and Bacteriophages Transformation: Early Studies

7. Figure 10-3 Copyright © 2006 Pearson Prentice Hall, Inc.

8. Table 10-1 Copyright © 2006 Pearson Prentice Hall, Inc.

9. Evidence Favoring DNA as the Genetic Material Was First Obtained during the Study of Bacteria and Bacteriophages Transformation: The Avery, MacLeod, and McCarty Experiment

10. Figure 10-4 Copyright © 2006 Pearson Prentice Hall, Inc.

11. Evidence Favoring DNA as the Genetic Material Was First Obtained during the Study of Bacteria and Bacteriophages The Hershey–Chase Experiment

12. Figure 10-5 Copyright © 2006 Pearson Prentice Hall, Inc.

13. Figure 10-6 Copyright © 2006 Pearson Prentice Hall, Inc.

14. Evidence Favoring DNA as the Genetic Material Was First Obtained during the Study of Bacteria and Bacteriophages Transfection Experiments

15. Indirect and Direct Evidence Supports the Concept that DNA Is the Genetic Material in Eukaryotes Indirect Evidence: Distribution of DNA Indirect Evidence: Mutagenesis

16. Table 10-2 Copyright © 2006 Pearson Prentice Hall, Inc.

17. Figure 10-7 Copyright © 2006 Pearson Prentice Hall, Inc.

18. Indirect and Direct Evidence Supports the Concept that DNA Is the Genetic Material in Eukaryotes Direct Evidence: Recombinant DNA Studies

19. RNA Serves as the Genetic Material in Some Viruses

20. Knowledge of Nucleic Acid Chemistry Is Essential to the Understanding of DNA Structure Nucleotides: Building Blocks of Nucleic Acids

22. Figure 10-9a Copyright © 2006 Pearson Prentice Hall, Inc.

23. Figure 10-9b Copyright © 2006 Pearson Prentice Hall, Inc.

24. Figure 10-10 Copyright © 2006 Pearson Prentice Hall, Inc.

25. Knowledge of Nucleic Acid Chemistry Is Essential to the Understanding of DNA Structure Nucleoside Diphosphates and Triphosphates

26. Figure 10-11 Copyright © 2006 Pearson Prentice Hall, Inc. (dATP)

27. Knowledge of Nucleic Acid Chemistry Is Essential to the Understanding of DNA Structure Polynucleotides

28. Figure 10-12 Copyright © 2006 Pearson Prentice Hall, Inc.

29. Figure 10-12a Copyright © 2006 Pearson Prentice Hall, Inc.

30. Figure 10-12b Copyright © 2006 Pearson Prentice Hall, Inc.

31. The Structure of DNA Holds the Key to Understanding Its Function Base Composition Studies X-Ray Diffraction Analysis

32. Table 10-3 Copyright © 2006 Pearson Prentice Hall, Inc.

33. Figure 10-13 Copyright © 2006 Pearson Prentice Hall, Inc.

35. The Structure of DNA Holds the Key to Understanding Its Function The Watson–Crick Model

36. Figure 10-14 Copyright © 2006 Pearson Prentice Hall, Inc.

37. Figure 10-14a Copyright © 2006 Pearson Prentice Hall, Inc.

38. Figure 10-14b Copyright © 2006 Pearson Prentice Hall, Inc.

39. Figure 10-14c Copyright © 2006 Pearson Prentice Hall, Inc.

40. Figure 10-15 Copyright © 2006 Pearson Prentice Hall, Inc.

41. Figure 10-16 Copyright © 2006 Pearson Prentice Hall, Inc.

42. Alternative Forms of DNA Exist

43. Figure 10-17 Copyright © 2006 Pearson Prentice Hall, Inc.

44. Figure 10-17a Copyright © 2006 Pearson Prentice Hall, Inc.

45. Figure 10-17b Copyright © 2006 Pearson Prentice Hall, Inc.

46. The Structure of RNA Is Chemically Similar to DNA, but Single Stranded

47. Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA Absorption of Ultraviolet Light (UV) Sedimentation Behavior

48. Figure 10-18 Copyright © 2006 Pearson Prentice Hall, Inc.

49. Figure 10-19 Copyright © 2006 Pearson Prentice Hall, Inc.

50. Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA Denaturation and Renaturation of Nucleic Acids

51. Figure 10-20 Copyright © 2006 Pearson Prentice Hall, Inc.

52. Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA Molecular Hybridization

53. Figure 10-21 Copyright © 2006 Pearson Prentice Hall, Inc.

54. Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA Fluorescent in situ Hybridization (FISH)

55. Figure 10-22 Copyright © 2006 Pearson Prentice Hall, Inc.

56. Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA Reassociation Kinetics and Repetitive DNA

57. Figure 10-23 Copyright © 2006 Pearson Prentice Hall, Inc. C/C 0 = 1/1+kC 0 t

58. Figure 10-24 Copyright © 2006 Pearson Prentice Hall, Inc.

59. Figure 10-25 Copyright © 2006 Pearson Prentice Hall, Inc.

60. Figure 10-26 Copyright © 2006 Pearson Prentice Hall, Inc.

61. Many Analytical Techniques Have Been Useful during the Investigation of DNA and RNA Electrophoresis of Nucleic Acids

62. Figure 10-27 Copyright © 2006 Pearson Prentice Hall, Inc.