1. The University of SydneyPage 1 Translational Research Closing the Gap Between Practice and Research Professor Tim Shaw Director Research in Implementation Science and eHealth (RISe) Faculty, Health Sciences

2. What is Translational Research? 2 Applied research Basic research

3. Why Translational Research? Consistent evidence of failure to translate research findings into clinical practice 30-40% patients do not get treatments of proven effectiveness 20–25% patients get care that is not needed or potentially harmful (Runciman 2012; Grimshaw 2012; Schuster, McGlynn, Brook, 1998; Grol 2001)

4. Clinical & Translational Research: Valleys of Death Basic Biomedical and HSR Research Clinical Science & Knowledge Clinical Practice & Health Decision Making Translational Continuum – 17 years Valley 1 Valley 2 Copyright University of Pittsburgh 2006 Reis et al. Clin Transl Sci 2008 14% enter into standard clinical practice; 1% lead to important health impacts Thanks to Eva Grunfeld

5. Translation DiscoveryTrials Implementation Improved Patient Outcomes T1T2 T3

6. Purposeful intent around an identified issue/priority What’s so special? Isn’t that what we have all being doing anyway?

7. Barriers

8. Silos Academia Hospitals Disciplines Geography QI Capacity and understanding

9. Eg Timelines Language End points Methodologies Rewards Different planets? Academia/IS QI/Practice

10. Lack of access to data

11. Enablers

12. Building capacity

13. New Partnerships and Funding Advanced Health Research and Translation Centres Translational Cancer Research Centres Academic Health Units

14. A systematic approach to identifying and closing evidence-practice gaps Longitudinal Programs Tim Shaw, Nicole Rankin, Sarah York, Phyllis Butow, Jane Phillips, Kate White, Jane Young, Puma Sundaresan, Sally Pearson, John Symes

15. Engaging MDTs in Translational Research High Performing Tumour Program

16. Paul Harnett, Lynleigh Evans, Henry Pleass, Guy Eslick, Arthur Richardson, Kim Hill, Kylie Museth, Anna Janssen, Tracy Robinson, Tim Shaw High Performing Tumour Program

17. Impact on clinical practice + Impact on professional development + Impact on quality improvement + Generation of research questions WS-LHD staff, Tim Shaw, Paul Harnett, Anna Janssen, Kylie Museth Data Innovation Lab High Performing Tumour Program

18. Disruptive technology 18