1. Example of real co-funded call: JPND Rainer Girgenrath DLR-PT (Germany)

2. Albania Austria Belgium Canada Croatia Czech Republic Denmark Finland France Germany Greece Hungary Ireland Israel Italy Luxembourg Netherlands Norway Poland Portugal Romania Slovakia Slovenia Spain Sweden Switzerland Turkey United Kingdom JPND is the largest global ND research initiative led by 28 participating countries EU member states Associated countries Third countries We cannot tackle neurodegenerative diseases by acting as single countries Joint Programme – Neurodegenerative Disease Research (JPND)

3. Year Total funding Research Area No. of Projects 2011€ 14 MHarmonization of biomarkers4 2012€ 17 MRisk and Protective Factors5 2012€ 9 MEvaluation of Healthcare6 2013€ 12.5 MCross-Disease Analysis10 2013€ 7 MPreventive Strategies5 2014€ 0.5 M Working groups on longitudinal cohort studies 15 Total€ 60 M40 JPND: Joint transnational calls

4. Partnership with the EC: co-funded call Synergy between JPND and H2020: JPco-fuND up to € 10 M EC top-up funding Started in January 2015 Call on three topics for 2015 (€ 30 M national budget) Genetic, epigenetic and environmental risk + protective factors Longitudinal cohorts in ND research Advanced experimental models of ND

5. Organisation: Jpco-fuND Network Steering Committee (NSC) 25 funding organizations Executive Committee (ExCom) WP leader Coordinator: Philippe Amouyel Call Steering Committee (CSC) participating organizations Joint Call Secretariat (JCS)

6. Peer Review Procedure > - 6 monthsCall topic(s) - 3 monthsCall text

7. Peer Review Procedure Call text Topic(s) Participating organizations Funding duration: 3 yrs. Size of consortia: 3-8 Limitation of research groups from one country: 2 2 step review procedure Review criteria Eligibility criteria Earmarked budget National contact points

8. Peer Review Procedure > - 6 monthsCall topic(s) - 3 monthsCall text - 2 monthsCall procedures Memorandum of Understanding (MoU)

9. Peer Review Procedure Call procedures Boards/structure Eligibility Size of the consortia External collaborators Revision of a proposal PRP: composition, declaration Pre-proposal evaluation: written statements + PRP meeting Scoring 1-5, weighting of review criteria Feedback to applicants Formal check PRP/CSC meeting (full proposals) Time schedule

10. Peer Review Procedure > - 6 monthsCall topic(s) - 3 monthsCall text - 2 monthsCall procedures Memorandum of Understanding (MoU) - 1 monthCollect potential reviewers Country specific information Proposal template Electronic submission system Frequently asked questions (FAQ) Publication of the call(Call text and documents)

11. Peer Review Procedure 1 monthReviewers (from all countries) Chair Declaration (confidentiality, conflict of interest) signed 2 monthsDeadline Pre-proposals: 175 Pre-proposals Formal check (corrections within 48 hours) National eligibility check Reviewer assignment (3 per proposal) 3 monthsWritten evaluation (scores 1-5) 4 monthsCSC Meeting/Peer Review Panel (PRP) -> selection of top pre-proposals: 55

12. Peer Review Procedure 4 monthsInform applicants, Feedback: Decision/Evaluation text/final scores 5 monthsCompile Final Review Board Deadline Full proposals Formal check Reviewer assignment (3 per proposal) Summer break: months 6 + 7 8 monthsPRP Meeting:Final recommendation: 29 Final ranking list CSC Meeting:Funding gaps

13. Peer Review Procedure 8 monthsFunding gaps + possible solutions 1. increase national budget 2. cut budget of funded research groups 3. EC top-up funding 4. reject proposal 9 monthsFinal CSC decision Inform applicants Start national funding negotiation 11 monthsfirst projects start

14. Consortium agreement Minimum overall amount that needs to be spent receive max. EC contribution of 10 Mio. € is 30 Mio. €. Failures of funded transnational projects or budget cuts within their duration might reduce the final EU-Top-Up Funding as this will be based on real expense. The maximum budget available for co-funding of research projects is 7 Mio. € (10 Mio. € - 3 Mio. € management and unit costs). Australia, Canada, and Switzerland’s budget does not count for calculating the maximum co-funding amount.

15. Consortium agreement Goal: maximize the number of high quality proposals to be funded. First explore all funding solutions to unblock situations at the national level. Each final sum paid by the partners will be topped-up by 10% with EC contribution. If this leads to a situation where insufficient funds are remaining from the EC contribution to fund further projects, this percentage may be revised by the CSC. A part of the EC contribution will be used to fund partners for which no more national funds are available (filling the gap). The distribution of remaining funds, if any, shall be discussed and decided during a CSC meeting.

16. EC top-up budget distribution Partial sums RankTotal Country A Country B Country C Country D Country E Country F Country G 11.136.62200198.00000249.600569.130 22.542.90300198.0000333.333249.6001.282.182 33.577.486199.3600198.0000333.333249.6001.817.274 45.027.905199.3600398.0000333.333646.3392.330.954 55.497.072199.3600398.0000333.333805.4592.541.001 66.990.361199.3600398.0000333.3331.117.9593.021.221 78.175.481199.3600398.0000333.3331.303.0793.521.221 89.679.168199.3600398.000315.000333.3331.699.0393.811.398 911.392.346199.3600398.000764.478333.3331.859.0394.223.598 1011.917.146199.3600598.000764.478333.3332.059.0394.223.598 1112.735.146199.3600598.000764.478333.3332.059.0394.523.598 1213.759.494199.3600598.000764.478333.3332.309.0394.722.946 1314.359.554199.3600598.000764.478333.3332.509.0394.923.026 1415.601.940199.3600598.000925.466494.3212.509.0395.219.486 1516.901.920199.3600798.000925.466494.3212.509.0395.719.486 1617.912.098199.3600798.000925.466494.3212.736.5436.002.160 Possible funding Gap filling in order of ranking

17. Reimbursement of at least 10% of actual budget (without AU, CA, CH) a.10 % of actual budget if no gap filling is used b.0 % if already 10% are used for gap filling c.1-9 % if less than 10 % are used for gap filling Total budget e.g. 30.000.000 €Abc Actual budget199.000500.000650.000 Gap filling0130.00029.000 Reimbursement19.900036.000 Additional reimbursement to reach guaranteed reimbursement (%) 10 %0 %5 % Actual reimbursement10 %26 %10 % EC top-up budget distribution

18. We strongly recommend to use the EC money primarily for gap filling -> more funded projects -> more EC top-up money EC top-up budget distribution

19. ERA-NET Cofund EC requirements for co-funded calls Call text received at least 30 days before publication Call open for at least 60 days Two-step procedure Only eligible entities invited to step 2 At least three independent experts (reviewer) per full proposal Review criteria:1. excellence 2. impact 3. quality and efficiency of the implementation No jumping in the ranking list Confidentiality

20. ERA-NET Cofund Submit to the EC: a) Ranking list b) Observers’ report c) Joint selection list d) Signed commitment on availability of funds e) Participants and abstracts

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