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MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

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Presentation on theme: "MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by."— Presentation transcript:

1 MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by Sashwati Roy, Savita Khanna, Syed-Rehan A. Hussain, Sabyasachi Biswas, Ali Azad, Cameron Rink, Surya Gnyawali, Shani Shilo, Gerard J. Nuovo, and Chandan K. Sen Cardiovasc Res Volume 82(1):21-29 April 1, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

2 miR expression profiling in hearts subjected to ischaemia–reperfusion. Sashwati Roy et al. Cardiovasc Res 2009;82:21-29 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

3 Induction of miR-21 in the infarct region of ischaemia-reperfused murine heart: a laser-capture microdissection based approach. Sashwati Roy et al. Cardiovasc Res 2009;82:21-29 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

4 Localization of miR-21 in ischaemia-reperfused mouse heart regions. Sashwati Roy et al. Cardiovasc Res 2009;82:21-29 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

5 Direct regulation of phosphatase and tensin homologue in cardiac fibroblasts by miR-21. Sashwati Roy et al. Cardiovasc Res 2009;82:21-29 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

6 miR-21 regulates MMP-2 expression in cardiac fibroblasts via a PTEN-AKT-phosphorylation- dependent pathway. Sashwati Roy et al. Cardiovasc Res 2009;82:21-29 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

7 Decreased phosphatase and tensin homologue and increased MMP-2 expression in the infarct region of heart. Sashwati Roy et al. Cardiovasc Res 2009;82:21-29 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

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