1. Prolozone Therapy Workshop
Dr. James Lemire FAAFP,CFMP
October 22, 2015

2. Credentials: Education BA 1968-1972 University Massachusetts
Board
Certifications Family Practice Initial certification:
(Recertified: , 1991, 1997, 2004 and 2014 )
  American College Sports Medicine–certified team physician-1986
  American College for Advancement of Medicine-Basic Chelation 2001
International Oxidative Medicine Assoc. Board certification-2002
  American College for Advancement of Medicine- CCT – 2011
  Institute of Functional Medicine Certified Practitioner – 2013
Education
BA University Massachusetts
Amherst, Mass
Phi Beta Kappa
MD Tulane University Medical School
New Orleans, La

3. Professional Experience
Lakewood Family Medicine
Holland, Mi
Family Physician
Founded a practice
There were 9 Family Physicians and 3 PA’s
Family Care Specialists, Ocala, Fl
2000-present James E Lemire MD PA Ocala, Fl
Lemire Clinic
Founded Functional medicine family practice
Including chelation therapy and IV nutrition
2011-present Medical Director / Founder Connections Community
Clinic for the Homeless and Indigents
2012-present Xymogen Nutraceuticals Medical Board of Advisors
2014-present Lemire Family Practice PLLC.
Personalized Health Care Practice

4. Memberships American College for Advancement of Medicine
Professional American Academy of Family Practice
Memberships American College for Advancement of Medicine
Christian Medical and Dental Association
Institute of Functional Medicine
Academy Comprehensive Integrative Medicine (ACIM)
Publications Ray and Lemire 1995 “Liver laceration in an Intercollegiate Football player.” Journal of Athletic Training.
Krupp, Lee, Diem and Lemire 1975 “Prognostic Parameters in Clinical Staging Criteria in Epidermoid Carcinoma of the Vulva.” Obstetrics and Gynecology
(research mentioned in Dr Barry Sears book “The Zone and Omega 3 Therapy”)
Natural Awakenings Magazine present
Ultimate Guide for Natural Health in the 21st Century 2012 E-book
Top 20 Alternative Doctors in America Contributor

5. Outline What is prolozone? History of prolotherapy & prolozone
Who invented prolozone & when?
Why prolozone & who benefits?
How is prolozone done?
Where is it done?
Dr. Rowen pearls
Summary-review

6. Definitions
Ozone therapy is the use of medical grade ozone (highly reactive pure 03) to create healing and regeneration within the body.
Prolozone is a new phrase combining the word ozone and the Latin word prioli which means to regenerate or rebuild.

7. OZONE REGULATES OXIDATIVE STRESS IMPROVES METABOLISM OF OXYGEN
METABOLIC REGULATOR
BROAD SPECTRUM GERMICIDE
IMPROVES METABOLISM OF OXYGEN

8. History
Ozone was first discovered in 1840 by Christian Friedrich Schonbein.
In 1932, Swiss dentists first used ozonated water as a disinfectant.
In 1950, two German doctors developed the first ozone generator for medical use.
European clinics have practiced ozone therapy for 50 years or more.
Ozone therapy was first introduced in the US in the early 1980s, and has been increasingly used ever since.
Prolozone therapy, developed by Frank Shallenberger MD, is a combination of ozone therapy , neural therapy and prolotherapy

10. Uses of Ozone Therapy
Ozone has been shown to be highly successful in a wide variety of clinical conditions:
Diabetic foot ulcers
Dental root canal infections & chronic gingivitis
Elephantiasis
Bedsores, psoriasis, eczema
Tinnitus, vertigo, migraines
Dyspnea of any origin

11. Prolozone is a mixture of Ozone and other active ingredients:
Procaine
B 12 B6
Dextrose
Homeopathics
others

13. 0zone (O3) Unstable & needs extra electrons
Creates peroxides that penetrate membranes
Oxidizes NADH to NAD & generates O2
This process of hyper-oxygenation and NADH oxidation drives the cell into an elevated ATP production mode.
Given the right nutrients and anti-inflammatories, the cell heals itself and the surrounding tissue.

14. Procaine
Blocks pain
Stabilizes and restores damaged neurological membrane potentials (NEURO reset)

15. Vitamin B 12 B12 is water-soluble & safest form is hydroxocobalamin
Critical to healthy nerves and red blood cells
Utilized in protein metabolism
Promotes healthy collagen formation
Utilized in inflammation reduction within cells
Is bright red in its natural
form

16. Vitamin B6 Vitamin B6 is water-soluble
Vital for conversion of food to energy
Utilization of proteins
Important for collagen formation

17. Dextrose Blocks the capsaicin receptor Inhibits substance P
Blocks cyclic inflammation
Tightens bonds between collagen-rich tissue i.e. tendons , ligaments, cartilage & joint capsules

18. Homeopathics Homeopathic anti-inflammatories Regenerative
Traumeel: pain-reducing homeopathic
Zeel: cartilage-rebuilding homeopathic

19. Why Prolozone? Pain reduction Tissue regeneration Avoid surgery
Cost responsibility
Rapid recovery
Patient demand- there is a transition happening
Less is more

20. Complications of Surgery
Surgical error
Complications- bleeding, infection, others
Pain
Scar tissue
Decreased function and range of motion
Delay return to normal activity (recovery)
Nerve damage
Other

21. Unnecessary Surgery

22. In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic débridement were no better than those after a placebo procedure.

23. Who Benefits from Prolozone?
Everyone, Everywhere!

24. Common Sports Injuries

25. Sprains/strain/pulls/tears/fracture
All tissue it designed with give & have elasticity.
Sprains, strains holes, tears and even fractures are result of the forces of injury overcoming the elasticity of the tissue involved.

27. Cumulative Injury Cycle

28. BASIC….. IT CAN BECOME VERY EXOTIC.
How To Make
Ozone machine: for most injections set 20 to 50 gamma
Some research suggests higher settings, some lower
**Vital to use pure oxygen and not a concentrator
Use within 10 minutes of drawing
The mix: 0.5 to 1 mL of dextrose 5%
1-2 mL of B12 (5 mg/mL)
0.5-1 mL of B6 open ( 5 mg/mL)
½ - 1 vial of Traumeel and or Zeel
6-8 mL of procaine 2%
BASIC….. IT CAN BECOME VERY EXOTIC.

29. Where To Give Areas to avoid: the spinal column Everywhere it hurts.
C1-C4 no man’s zone….or woman’s
Avoid the vertebral arteries
avoid large vessels
Avoid direct injection into large nerves
* Can treat around them all day long.

30. Conditions Responsive to Prolozone
Sinus infections
Sciatica
Plantar fasciitis
Carpal tunnel syndrome
Rotator cuff tears
Tennis elbow and virtually any other sports injury.
Pelvic disorders
TMJ
Neck pain
Hip Pain
Back pain
Knee pain
Degenerated discs
Herniated discs
Post-surgical pain
Dental infections
Non-union fractures

31. Prolozone Summary Bypasses the wall of inflammation and edema
Nutrients and oxygen are placed at the point of need for rebuilding tissue
Used for decades- with extensive research & success
Safe
Effective 75 to 95% recovery
combined with proper diet and supplementation success rate is even higher

32. References

33. Pearls by Dr. Robert Rowen
Why do we often get immediate results that are lasting when the effects of local anesthetic are gone in minutes?
Answer: Procaine works instantly so you know that you got your treatment in the right spot when you relieve the patient of pain from the injection. But when the pain doesn’t return after 30 to 60 minutes something else is happening. Ozone has gone to work immediately to lower/modulate inflammatory mediators.
It is the inflammation that causes pain. Knock out the inflammation & you knock out the pain. The oxygen residue is directly “what the doctor ordered” for oxygen starved tissues.
Hypoxic cells cannot regenerate or repair. They have just been given a free bolus of desperately needed oxygen into tissues where diffusion may be impaired.

34. Robert Rowen M.D.

35. What about delayed side effects?
Usually there is some change with the injection, helping you feel comfortable that you’ve chosen the correct site. But the real effect steps in about 2 to 5 days later. Why the delay?
I believe it’s a situation were the mere presence of ozone to modulate the inflammation is not enough for an instant effect. It requires several more days for the ATP induced by the new presence of oxygen to show up in the form of actual tissue healing and pain reduction.

36. Dr. Rowen’s success rates
Knees, neck, backs-approximate % overall improvement.
Hips with a lateral approach about 50% improvement or with anterior approach which some teach approximate 66% overall improvement.
plantar fasciitis close to 100%
Shoulders 50% clearing of frozen shoulder quickly may need 3 to 4 more treatments.
ankle sprains - 80%

37. Prolozone VS Prolotherapy
Ozone being a gas, spreads quickly far and wide. So unlike prolotherapy you don’t have to be spot on. The gas travels and seemingly everywhere it flows/touches, healing is enabled.
Prolotherapy use requires 20/30 more needle sticks than prolozone.
Prolotherapy can make the patient worse for the first 48 hours before benefits begin kicking in.
Patients come in sometimes reluctant for prolotherapy because they know they might feel worse tomorrow.
Precision injections required which taxes the individual physician

38. Dr. Rowen’s failures/pitfalls
No one ever gets 100%
Some patients are slow to come around. It may take 4 to 6 sessions to finally show improvement. Keep it up, they usually have improvement within the six sessions. Usually with continued improvement. If no improvement within six sessions, I will discontinue. The Cubans will go to 10.
No need to hit the right area although, since the gas is very forgiving.

39. Final Thoughts Prolozone is easy to tolerate
If it hurts, it only does so for about 60 seconds
Faster results
Better results
Patients are eager to come back for more treatments if needed
Help patients to avoid surgery where they are told: “There is bone on bone which requires joint replacement”

40. Additional References:
Thank you