1. In Vivo Biological Response to Vitamin E and Vitamin-E- Doped Polyethylene by Bryan T. Jarrett, Jennifer Cofske, Andrew E. Rosenberg, Ebru Oral, Orhun Muratoglu, and Henrik Malchau J Bone Joint Surg Am Volume 92(16):2672-2681 November 17, 2010 ©2010 by The Journal of Bone and Joint Surgery, Inc.

2. Representative histological section of a knee capsule from a New Zealand White rabbit two weeks after injection of pure synthetic vitamin E (10 μL), showing signs of acute and chronic inflammation with surface fibrin deposition and cellular debris (hematoxy... Bryan T. Jarrett et al. J Bone Joint Surg Am 2010;92:2672- 2681 ©2010 by The Journal of Bone and Joint Surgery, Inc.

3. Representative histological section of a knee capsule from a New Zealand White rabbit twelve weeks after injection of vitamin-E solution (2 mL of 5 mg/mL), showing no synovial abnormalities (hematoxylin and eosin). Bryan T. Jarrett et al. J Bone Joint Surg Am 2010;92:2672- 2681 ©2010 by The Journal of Bone and Joint Surgery, Inc.

4. Subcutaneous pouch surrounding a vitamin-E-doped ultra-high molecular weight polyethylene plug after two weeks in vivo, showing evidence of acute inflammation and tissue repair (hematoxylin and eosin). Bryan T. Jarrett et al. J Bone Joint Surg Am 2010;92:2672- 2681 ©2010 by The Journal of Bone and Joint Surgery, Inc.

5. Subcutaneous pouch surrounding vitamin-E-doped ultra-high molecular weight polyethylene plug after twelve weeks in vivo, showing evidence of stable fibrous encapsulation (hematoxylin and eosin). Bryan T. Jarrett et al. J Bone Joint Surg Am 2010;92:2672- 2681 ©2010 by The Journal of Bone and Joint Surgery, Inc.

6. Representative example of pseudocapsule formed around the implant from the vitamin-E group with a gross papillary structure and changes in architecture (the black suture indicates the superior direction). Bryan T. Jarrett et al. J Bone Joint Surg Am 2010;92:2672- 2681 ©2010 by The Journal of Bone and Joint Surgery, Inc.

7. Representative histological image of a smooth surface pseudocapsule formed around the implant with synovial-like cells at the surface with underlying fibrosis (hematoxylin and eosin). Bryan T. Jarrett et al. J Bone Joint Surg Am 2010;92:2672- 2681 ©2010 by The Journal of Bone and Joint Surgery, Inc.