1. AGRID Automated Glucose Reading Insulin Dispenser www.cs.odu.edu/~svijayak/MainPageCS410.html www.cs.odu.edu/~svijayak/MainPageCS410.html Presented by T. Gatdula Co-presenters S. Vijayakumar D. Yang

2. Problem Statement Diabetics do not follow their prescribed insulin regimen.

3. Agenda Societal problem Problem statement Project goal Component requirements Benefits Obstacles Risks & Mitigators Preliminary budget Projected schedule Management methods Resource requirements

4. American Diabetes Statistics 16 million cases of diabetes 2,500 new cases daily 7 th leading cause of death 193,140 deaths in 1996 $44 billion in direct medical costs *Statistics from ADA & NIDDK

5. Diabetes Management Survey 2/3 find regimen difficult to manage 41% “unsuccessful” at management 3 in 5 do not monitor as prescribed 17% do not maintain insulin regimen 1 in 5 find regimen restricting *Survey by Eli Lilly company

6. Survey- Diabetics

7. Survey- Monitoring

8. Problem Statement Diabetics do not follow their prescribed insulin regimen.

9. Project Goal Given a simplified insulin protocol, insulin-dependent diabetics will be more likely to maintain their prescribed insulin regimen.

10. Existing Monitoring Devices ProductCostAccuracyIssuesAccessories Glucose Monitor $890/ annually 98-99%Invasive, Calluses Strips, Lancets Glucose Watch $260100%Itchiness in area Batteries

11. Existing Dispensing Devices ProductCostAccuracyIssuesAccessories Insulin Pen$3599%Intrusive, Precision Needles Syringe$23/100100%Intrusive, Precision Disposal System Insulin Pump $4,00098.6%Intrusive, Complex Needles, Tubing MedicationVaries RegimentedN/A Insulin Patch ~$3.20Not Released Final Testing Phase N/A

12. Component Requirements 12 6 543 8907 Enter Blinker 100 Input Ultra Sound AGRID Patch

13. Functional Diagram User InfoMonitor Warning Ultra Sound Warning High Computational Device Low Within Range Patch

14. What AGRID Will Do Glucose monitoring Virtually non-invasive Continuous Insulin dispensing Non-invasive Continuous

15. What AGRID Will Not Do Not a cure for diabetes Not for those with minimal diabetes

16. Project Objectives Research Budget/cost projection SBIR grant proposal Acquisition of materials Building of prototype Validate product

17. AGRID Company Structure

18. Obstacles Government approval Side effects Societal reluctance

19. Benefits All-in-one Convenient Non-invasive Unobtrusive Peace of mind

20. Risks and Mitigators Diabetes curedVery far into the future Simpler regimentation becomes available Our solution is simple Unable to acquire government approval Alter product to meet requirements Unit not covered by insuranceReduce sales Unable to attain user-rightsFind alternative devices

21. Budget- Initial Development LicensingGlucowatch20,000 CostsInsulin Patches80,000 Ultrasound Device50,000 Software Development 30,000 Development Costs $180,000 Testing$200,000 TOTAL$380,000

22. Budget- Production UnitAGRID500 Costs@ 200 units $100,000 OperationTesting2,000 CostMaintenance5,000 Computational Device Research & Development 10,000 $17,000 TOTAL$117,000

23. Profit Projections AGRID500 Retail55050 @100,000 units $5,000,000 Insulin Patch3 Retail3.10.10 @365 annual @ 100,000 units $3,650,000 TOTAL$8,650,000

24. Schedule Concept development- 3 months Prototype design- 5 months Pre-production design- 6 months Production- 36 months Concept Development Prototype Design Pre-Production Design Production 3 months 5 months 6 months36 months

25. Conclusion Societal need Financially feasible Marketable Within time constraints Greater quality of life

26. Research Sites www.diabetes123.com www.childrenwithdiabetes.com www.nih.gov www.dcct.com www.glucowatch.com www.sontra.com www.niddk.nih.gov