1. 1 SURVEY OF BIOCHEMISTRY Lipids & Biological Membranes

2. 2 CETL Course Survey(s) Course-Instructor Opinion Survey (CIOS) –http://www.coursesurvey.gatech.edu –Also on T-Square Home Page Pilot Survey –Go to T-Square: Announcements for link to survey –Focus groups to learn more about student opinions –Deadline: August 3, 2008 –IRB Approval requested: minimal risk

3. 3 PRS Update Scores on T-Square this weekend Next week –Mon: Fatty Acid Oxidation –Wed and Fri: Course Review via PRS –Point Summary 75-100% of total points = 10 PRS POINTS 50-74% of total points = 5 PRS POINTS 1-49% of total points = 1 PRS POINT 0% = 0 PRS POINTS

4. 4 Types of Lipids Fatty Acids Triacylglycerols Glycerophospholipids Sphingolipids Steroids Isoprenoids Eicosanoids

5. 5 Fatty Acids Carboxylic acids with nonpolar hydrocarbon chain Fatty acids can be saturated with H’s or unsaturated with H’s

6. 6 Fatty Acids Double bonds can be cis or trans - usually see cis form Cis form causes molecule to kink

7. 7 Common Fatty Acids Know C12 - C20 names and structures!

8. 8 Triacylglycerols R 1, R 2 and R 3 are fatty acid chains Most abundant! Energy reservoirs

9. 9 Glycerophospholipids R 1 and R 2 are fatty acid chains X = functional group Abundant in bio membranes

10. 10 Classes of Glycerophospholipids

11. 11 Phospholipases

12. 12 Sphingolipids Sphingolipids are also found in membranes.

13. 13 Sphingolipids Sphingomyelin Compose 10-20% of plasma membrane Head group could also be a phosphoethanolamine group - O 3 P-CH 2 CH 2 NH 3 +

14. 14 Sphingolipids Cerebrosides Sugar head group and no phosphate From Avantilipids.com

15. 15 Sphingolipds Gangliosides Most complex, found in brain tissue Be familiar with structure but do not memorize for Final Exam

16. 16 Steroids: Structure of Cholesterol Know this!

17. 17 Steroids

18. 18 Steroids

19. 19 Arachidonic Acid Breakdown Involved in pain and fever, blood pressure, blood coagulation, reproduction

20. 20 Micelles

21. 21 Lipid Bilayer and Glycophorin A

22. 22 Biological Membranes