Presentation is loading. Please wait.

Presentation is loading. Please wait.

OLSON, M.L., ET AL Vitamin D Deficiency in Obese Children an Its Relationship to Glucose Homeostasis J Clin Endocrinol Metab, 97, 279-285, 2012.

Similar presentations


Presentation on theme: "OLSON, M.L., ET AL Vitamin D Deficiency in Obese Children an Its Relationship to Glucose Homeostasis J Clin Endocrinol Metab, 97, 279-285, 2012."— Presentation transcript:

1 OLSON, M.L., ET AL Vitamin D Deficiency in Obese Children an Its Relationship to Glucose Homeostasis J Clin Endocrinol Metab, 97, 279-285, 2012

2 Study Objective To compare prevalence of vitamin D deficiency in obese versus non-overweight children. Examine relationships between:  Dietary habits and serum 25(OH)D levels  Abnormal glucose metabolism and obesity in children Cross-sectional observational study- no intervention was implemented

3 Subjects 411 obese and 89 non-overweight children (aged 6-16 years) residing in North Texas  Grouping based on BMI percentile-for-age: Obese= >95 th percentile, non= <85 th percentile  Adequate sample size, but could have included more non-overweight to better compare  Convenience sample of non-overweight subjects from Endocrinology Center for Hyperthyroidism  No known relationship between thyroid and vitamin D status Same exclusion criteria for both groups  Meds: anticonvulsant, glucocorticoid, and/or vitamin D supplement  Health Status: Hepatic dz, renal dz, malabsorptive disorder, bone metabolism disorder, hypothalamic dz, genetic predisposition to obesity

4 Accounted for multiple subject characteristics Age BMI Gender Ethnicity Season Dietary practices

5 Test Procedures Used common, standard procedures determined to be reliable and valid:  Serum 25(OH)D  Diabetes Risk Factors (validated by Amer Diabetes Assoc)  OGTT  Fasting plasma glucose and insulin  HgbA1C  HOMA-IR (insulin resistance and beta-cell function) All measurements taken in same way in both groups Result evaluation based to gender, race, and season in both groups

6 Study Design- valid Used standardized, accurate measures of glucose metabolism and vitamin D status Included variety of subjects: different genders, races, ages Matched non-overweight subjects to obese based on age, race, and season  more accurate comparison

7 Relevant Outcomes Obese had less seasonal variation in vitamin D status (p<0.03) Breakfast skipping and high soda intakes were associated with lower vitamin D status (p<0.001) When adjusted for age and BMI, vitamin D status negatively correlated with HOMA-IR and OGTT (p=0.001 and p=0.04)  Lower vitamin D status is associated with T2D risk factors in obese children

8 Author’s Conclusions Study results show a negative relationship between vitamin D status and BMI in children Glucose metabolism is related to vitamin D status Limitation: unable to account for physical activity or sun-light exposure  Could aid in better understanding differences in vitamin D status between the 2 groups

9 Implications for Practice Nutrition Professionals:  Raise awareness of dietary factors negatively affecting vitamin D status in children (breakfast skipping, soda consumption)  Highlight need for early dietary interventions Clinical Professionals:  Suggests need for further study of vitamin D supplementation as a potential treatment for conditions such as insulin resistance


Download ppt "OLSON, M.L., ET AL Vitamin D Deficiency in Obese Children an Its Relationship to Glucose Homeostasis J Clin Endocrinol Metab, 97, 279-285, 2012."

Similar presentations


Ads by Google