1. Chapter 24: Urinary System Chapter 24: Urinary System

2. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 2 Lesson 24.1 Objectives List four organs of excretion. Describe the major organs of the urinary system. Describe the location, structure, blood supply, nerve supply, and functions of the kidneys. Explain the role of the nephron unit in the formation of urine. List four organs of excretion. Describe the major organs of the urinary system. Describe the location, structure, blood supply, nerve supply, and functions of the kidneys. Explain the role of the nephron unit in the formation of urine.

3. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 3 Lesson 24.1 Objectives (cont’d.) Explain the three processes involved in the formation of urine: filtration, reabsorption, and secretion. Describe the hormonal control of water and electrolytes by the kidneys. List the normal constituents of urine. Describe the structure and function of the ureters, urinary bladder, and urethra. Explain the three processes involved in the formation of urine: filtration, reabsorption, and secretion. Describe the hormonal control of water and electrolytes by the kidneys. List the normal constituents of urine. Describe the structure and function of the ureters, urinary bladder, and urethra.

4. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 4 Excretion Organs of excretion: –Kidneys –Sweat glands –Lungs –Intestines Organs of excretion: –Kidneys –Sweat glands –Lungs –Intestines

5. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 5 Excretion (cont’d.) Urinary system organs: –Kidneys –Ureters –Urinary bladder –Urethra Urinary system organs: –Kidneys –Ureters –Urinary bladder –Urethra

6. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 6 Excretion (cont’d.) A. Organs of the urinary system.

7. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 7 Kidneys Location: retroperitoneal, high on the posterior wall of the abdominal cavity Structure: reddish-brown, beanlike shape, enclosed in a tough fibrous capsule; three distinct regions: –Renal cortex –Renal medulla –Renal pelvis Location: retroperitoneal, high on the posterior wall of the abdominal cavity Structure: reddish-brown, beanlike shape, enclosed in a tough fibrous capsule; three distinct regions: –Renal cortex –Renal medulla –Renal pelvis

8. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 8 Kidneys (cont’d.) B. Internal structure of a kidney.

9. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 9 Kidneys (cont’d.) Blood supply: renal artery, which arises from the abdominal aorta; renal vein, which empties into the inferior vena cava Nerve supply: renal nerves; primarily sympathetic nerves Blood supply: renal artery, which arises from the abdominal aorta; renal vein, which empties into the inferior vena cava Nerve supply: renal nerves; primarily sympathetic nerves

10. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 10 Kidneys (cont’d.) Functions: –Excrete nitrogenous waste (urea, uric aid, ammonia, and creatinine) –Regulate blood volume by determining the amount of water excreted –Help regulate the electrolyte content of the blood –Play a major role in the regulation of acid-base balance by controlling the excretion of H + –Play a role in regulation of blood pressure –Play a role in regulation of RBC production Functions: –Excrete nitrogenous waste (urea, uric aid, ammonia, and creatinine) –Regulate blood volume by determining the amount of water excreted –Help regulate the electrolyte content of the blood –Play a major role in the regulation of acid-base balance by controlling the excretion of H + –Play a role in regulation of blood pressure –Play a role in regulation of RBC production

11. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 11 Urine Making: The Nephron Unit Nephron: functional unit of the kidney; two parts: –Renal tubules: Bowman’s capsule, proximal convoluted tubule, loop of Henle, distal convoluted tubule, collecting duct –Renal blood vessels: renal artery, afferent arteriole, glomerulus, efferent arteriole, peritubular capillaries, renal vein Nephron: functional unit of the kidney; two parts: –Renal tubules: Bowman’s capsule, proximal convoluted tubule, loop of Henle, distal convoluted tubule, collecting duct –Renal blood vessels: renal artery, afferent arteriole, glomerulus, efferent arteriole, peritubular capillaries, renal vein

12. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 12 Urine Making: The Nephron Unit (cont’d.) The nephron unit: tubular structures.

13. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 13 Urine Making: The Nephron Unit (cont’d.) The nephron unit.

14. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 14 Urine Making: The Nephron Unit (cont’d.) Three processes of urine formation: –Glomerular filtration –Tubular reabsorption –Tubular secretion Three processes of urine formation: –Glomerular filtration –Tubular reabsorption –Tubular secretion

15. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 15 Urine Making: The Nephron Unit (cont’d.) Glomerular filtration: caused by the blood pressure difference between the glomerulus and Bowman’s capsule Glomerular filtrate: water and dissolved substances filtered into Bowman’s capsule Glomerular filtration rate (GFR): rate at which glomerular filtration occurs Glomerular filtration: caused by the blood pressure difference between the glomerulus and Bowman’s capsule Glomerular filtrate: water and dissolved substances filtered into Bowman’s capsule Glomerular filtration rate (GFR): rate at which glomerular filtration occurs

16. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 16 Urine Making: The Nephron Unit (cont’d.) Tubular reabsorption: process by which glomerular filtrate moves from the tubules into the blood of the peritubular capillaries Diuresis: excess secretion of urine Diuretics: drugs that increase the production of urine Tubular reabsorption: process by which glomerular filtrate moves from the tubules into the blood of the peritubular capillaries Diuresis: excess secretion of urine Diuretics: drugs that increase the production of urine

17. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 17 Urine Making: The Nephron Unit (cont’d.) Tubular secretion: process by which very small amounts of substances from the peritubular capillaries move into the tubules Secreted substances: potassium ions (K + ), hydrogen ions (H + ), uric acid, ammonium ions, and drugs Tubular secretion: process by which very small amounts of substances from the peritubular capillaries move into the tubules Secreted substances: potassium ions (K + ), hydrogen ions (H + ), uric acid, ammonium ions, and drugs

18. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 18 Hormones That Work on the Kidneys Aldosterone Antidiuretic hormone (ADH) Natriuretic peptides –Atrial natriuretic peptide (ANP) –Brain natriuretic peptide (BNP) Parathyroid hormone Aldosterone Antidiuretic hormone (ADH) Natriuretic peptides –Atrial natriuretic peptide (ANP) –Brain natriuretic peptide (BNP) Parathyroid hormone

19. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 19 Hormones That Work on the Kidneys (cont’d.) Aldosterone: –Stimulates the reabsorption of sodium and water –Stimulates the excretion of potassium –Acts primarily on the distal tubule –Increases blood volume and blood pressure –Release is stimulated by angiotensin II Aldosterone: –Stimulates the reabsorption of sodium and water –Stimulates the excretion of potassium –Acts primarily on the distal tubule –Increases blood volume and blood pressure –Release is stimulated by angiotensin II

20. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 20 Hormones That Work on the Kidneys (cont’d.) The renin-angiotensin-aldosterone system.

21. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 21 Hormones That Work on the Kidneys (cont’d.) Antidiuretic hormone (ADH): –Stimulates the reabsorption of water –Works primarily on the collecting duct –Plays a role in determining blood volume and blood pressure –Release is stimulated by a decrease in blood volume and an increase in the concentration of solutes in the plasma Antidiuretic hormone (ADH): –Stimulates the reabsorption of water –Works primarily on the collecting duct –Plays a role in determining blood volume and blood pressure –Release is stimulated by a decrease in blood volume and an increase in the concentration of solutes in the plasma

22. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 22 Hormones That Work on the Kidneys (cont’d.) Natriuretic peptides: cause natriuresis, excretion of sodium (Na + ); decrease the secretion of aldosterone by the adrenal cortex –Atrial natriuretic peptide (ANP): secreted by the walls of the atria of the heart in response to an increase in the volume of blood –Brain natriuretic peptide (BNP): secreted by the walls of the ventricles in response to elevated ventricular pressure Natriuretic peptides: cause natriuresis, excretion of sodium (Na + ); decrease the secretion of aldosterone by the adrenal cortex –Atrial natriuretic peptide (ANP): secreted by the walls of the atria of the heart in response to an increase in the volume of blood –Brain natriuretic peptide (BNP): secreted by the walls of the ventricles in response to elevated ventricular pressure

23. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 23 Hormones That Work on the Kidneys (cont’d.) Parathyroid hormone (PTH): –Secreted by the parathyroid glands –Plays an important role in the regulation of two electrolytes –Stimulates the renal tubules to reabsorb calcium and excrete phosphate –Release stimulated by low plasma level of calcium Parathyroid hormone (PTH): –Secreted by the parathyroid glands –Plays an important role in the regulation of two electrolytes –Stimulates the renal tubules to reabsorb calcium and excrete phosphate –Release stimulated by low plasma level of calcium

24. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 24 Characteristics of Urine Amount (volume): average 1500 ml/24 hours pH: average 6.0 Specific gravity: slightly heavier than water (1.001 to 1.035) Color: yellow (amber, straw colored, deep yellow in dehydration, pale yellow with overhydration) Amount (volume): average 1500 ml/24 hours pH: average 6.0 Specific gravity: slightly heavier than water (1.001 to 1.035) Color: yellow (amber, straw colored, deep yellow in dehydration, pale yellow with overhydration)

25. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 25 Characteristics of Urine (cont’d.) Some abnormal constituents of urine: –Albumin: (albuminuria) indicates an increased permeability of the glomerulus; sometimes induced by exercise or pregnancy –Glucose: (glycosuria) usually indicates diabetes mellitus –Red blood cells: (hematuria) bleeding in the urinary tract; indicates inflammation, trauma, or disease Some abnormal constituents of urine: –Albumin: (albuminuria) indicates an increased permeability of the glomerulus; sometimes induced by exercise or pregnancy –Glucose: (glycosuria) usually indicates diabetes mellitus –Red blood cells: (hematuria) bleeding in the urinary tract; indicates inflammation, trauma, or disease

26. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 26 Characteristics of Urine (cont’d.) Some abnormal constituents of urine (cont’d.): –Hemoglobin: (hemoglobinuria) indicates hemolysis –White blood cells: (pyuria) indicates infection within the kidney or urinary tract –Ketone bodies: (ketonuria) usually indicates uncontrolled diabetes mellitus –Bilirubin: (bilirubinuria) usually indicates disease involving the liver and/or biliary tree Some abnormal constituents of urine (cont’d.): –Hemoglobin: (hemoglobinuria) indicates hemolysis –White blood cells: (pyuria) indicates infection within the kidney or urinary tract –Ketone bodies: (ketonuria) usually indicates uncontrolled diabetes mellitus –Bilirubin: (bilirubinuria) usually indicates disease involving the liver and/or biliary tree

27. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 27 Characteristics of Urine (cont’d.)

28. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 28 When the Parts Don’t Work Nephrotic syndrome: excretion of large amounts of protein in the urine, causing hypoalbuminemia Glomerulonephritis: autoimmune reaction to streptococcus Acute tubular necrosis (ATN): consequence of renal tubular damage Uremia and dialysis: urine in the blood can be prevented by dialysis, an artificial method of cleansing the blood Nephrotic syndrome: excretion of large amounts of protein in the urine, causing hypoalbuminemia Glomerulonephritis: autoimmune reaction to streptococcus Acute tubular necrosis (ATN): consequence of renal tubular damage Uremia and dialysis: urine in the blood can be prevented by dialysis, an artificial method of cleansing the blood

29. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 29 When the Parts Don’t Work (cont’d.)

30. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 30 Your Plumbing Urinary tract: –Ureters: connect the kidneys and bladder –Urinary bladder: temporary reservoir for storage of urine –Urethra: tube that carries urine from the bladder to the outside Urination: process of expelling urine from the bladder; also called micturition or voiding Micturition reflex: gives rise to a sense of urgency Urinary tract: –Ureters: connect the kidneys and bladder –Urinary bladder: temporary reservoir for storage of urine –Urethra: tube that carries urine from the bladder to the outside Urination: process of expelling urine from the bladder; also called micturition or voiding Micturition reflex: gives rise to a sense of urgency

31. Copyright © 2007 by Saunders, an imprint of Elsevier Inc. All rights reserved. 31 Your Plumbing (cont’d.) Organs of the urinary tract.