1. 1 Impact of Bioinformatics in our life and BME engineer responsibility Dr Fadhl Alakwaa fadhl-alakwa.weebly.com

2. OUTCOMES Why human Look differentthan Chimpanzee? 22 1 10/12/2013

3. OUTCOMES Why do we look different ? 33 2 10/12/2013

4. OUTCOMES Why our body is very complicated? 44 3 10/12/2013

5. OUTCOMES How much we know about our biological system? 55 4 http://www.pbs.org/wgbh/pages/frontline/shows/teenbrain/work/how.html 10/12/2013

6. OUTCOMES What is our role in solving life big mystery? BME 66 5 10/12/2013

7. DNA Our cell is the basic unit of our body 77 1 10/12/2013

8. DNA is composed of nucleotides 88 2 Phosphate Sugar Nitrogenous base A 10/12/2013

9. There are 4 nucleotide A G C T DNA is composed of nucleotide 99 3 Phosphate Sugar Nitrogenous base AA T G C 10/12/2013

10. 10 A T G C 5 P’3OH’ A T G C A T G C 53 4 DNA is composed of millions of nucleotides 10/12/2013

11. 11 A C G T A C G T A C G T A C G T No of base pairs= Genome Size HG= 3200 Mbp (Mb) 5 DNA is double strand connected with hydrogen bounds 10/12/2013

12. 12 6 DNA size= Genome size 10/12/2013

13. 13 SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC 7 How many different sequences we get? SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA 10/12/2013

14. 14 SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC 7 How many different sequence we get? SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA 4^ 3200 X10^6 10/12/2013

15. OUTCOMES Yes we are different because we came from different sequence. Twins has the same DNA sequence 15 2 10/12/2013

16. 16 SEQ 1: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCC 8 Data bases for all organism SEQ 2: AAAATTTTTTGGGGGGGGCCCCCCCCCCCACCCCCC SEQ N: AAAATTTTTTGGGGGGGGCCCCCCCCCCCCCCCCCA 4^ 3200 X10^6 10/12/2013

17. Start on End on 17 9 The Human genome project 10/12/2013

18. 18 10 Data bases for all organism The data bases sizes, logos 10/12/2013

19. OUTCOMES What is our role in solving life big mystery? BME Search and storage Sequence alignment 3D structure predication Computational biology System biology Bioinformatics Gene function ontology Drug discovery 19 5 10/12/2013

20. OUTCOMES Why human Look differentthan Chimpanzee? 20 1 10/12/2013

21. OUTCOMES What is our role in solving life big mystery? BME DNA sequencer M-RNA analysis PCR Electrophoresis 21 5 10/12/2013

22. Cell function = proteins Protein is composed of amino acids 22 1 Amino acid AA F N G G S T S D K COO - NH 3 + C R H Amino groupCarboxylic acid group 10/12/2013

23. 23

24. Protein is synthesized from genes 24 2 Genes located on DNA AA F N G G S T S D K 10/12/2013