1. © Cancer Research UK 2006 Registered charity number 1089464 The statistics in this presentation are based on the Bowel CancerStats report published in 2007. However, the incidence, mortality and survival statistics have been updated to reflect the latest available data. For more information about UK cancer statistics please contact stats.team@cancer.org.uk or visit http://info.cancerresearchuk.org/cancerstatsstats.team@cancer.org.uk http://info.cancerresearchuk.org/cancerstats Bowel Cancer

2. © Cancer Research UK 2006 Registered charity number 1089464 Figure One: Percentage distribution of cases by site within the large bowel, England, 1997-2000

3. © Cancer Research UK 2006 Registered charity number 1089464 Table One: Numbers and rates of new cases of bowel cancer, by sex, UK by country, 2006 EnglandWalesScotlandN.IrelandUK Cases Males16,7781,2141,87556320,430 Females14,0129571,63548017,084 Persons30,7902,1713,5101,04337,514 Crude rate per 100,000 population Males67.384.075.966.068.8 Females54.262.961.854.055.3 Persons60.773.268.659.961.9 Age-standardised rate (European) per 100,000 population Males54.961.861.362.956.0 95% CI54.155.858.365.358.564.057.768.155.356.8 Females3639.140.441.136.4 95% CI35.136.336.641.638.442.337.444.735.937.0 Persons44.449.4 50.845.3 95% CI43.944.947.351.547.851.147.753.944.845.7

4. © Cancer Research UK 2006 Registered charity number 1089464 Figure Two: Numbers of new cases and age-specific incidence rates for bowel cancer, by sex, UK, 2006

5. © Cancer Research UK 2006 Registered charity number 1089464 Table Two: Numbers and rates of new cases for colon and rectal cancer, by sex, UK, 2006 Number of cases Crude rate per 100,000 population Age-standardised rate (European) per 100,000 population ColonMales12,00540.432.5 Females11,37936.823.7 RectumMales8,42528.423.6 Females5,70518.512.7

6. © Cancer Research UK 2006 Registered charity number 1089464 Figure Three: Age-standardised* incidence rates for colorectal cancer, by sex, region of England, England, Scotland, Wales, Northern Ireland and Ireland, 1991-99 * to European standard population * to the European standard population

7. © Cancer Research UK 2006 Registered charity number 1089464 Figure Four: Age-standardised* incidence rates for bowel cancer, by sex, EU, 2006 estimates * to European standard population * to the European standard population

8. © Cancer Research UK 2006 Registered charity number 1089464 Figure Five: Age-standardised* incidence rates for colorectal cancer, by sex, world regions, 2002 estimates † to World standard population * to the European standard population

9. © Cancer Research UK 2006 Registered charity number 1089464 Figure Six: Age-standardised (European) incidence rates, bowel cancer, by sex, UK, 1993-2006 * to European standard population

10. © Cancer Research UK 2006 Registered charity number 1089464 Figure Seven: Household food consumption, Great Britain, 1974-2000

11. © Cancer Research UK 2006 Registered charity number 1089464 Figure Eight: The number of portions of fruit and vegetables eaten per day by adults aged 16 and over, England, 2004

12. © Cancer Research UK 2006 Registered charity number 1089464 Figure Nine: Trends in bodyweight, by sex, England, 1995 and 2004

13. © Cancer Research UK 2006 Registered charity number 1089464 Table Three: Staging of colorectal cancers UICC/TNMModified Dukes' Stage 0Carcinoma in situA Stage INo nodal involvement, no distant metastasis Tumour invades submucosa (T1, N0, M0) Tumour invades muscularis propria (T2, N0, M0) Stage IINo nodal involvement, no distant metastasisB Tumour invades into subserosa (T3, N0, M0) Tumour invades into other organs (T4, N0, M0) Stage IIINodal involvement, no distant metastasisC 1 to 3 regional lymph nodes involved (any T, N1, M0) 4 or more regional lymph nodes involved (Any T, N2, M0) Stage IVDistant metastasis (any T, any N, M1)D

14. © Cancer Research UK 2006 Registered charity number 1089464 Figure Ten: Age-standardised* one-year relative survival rate, colon cancer, by sex, England and Wales 1971-2006 * to the European standard population

15. © Cancer Research UK 2006 Registered charity number 1089464 Figure Eleven: Age-standardised* one-year relative survival rate, rectal cancer, by sex, England and Wales, 1971-2006 * to the European standard population

16. © Cancer Research UK 2006 Registered charity number 1089464 Figure Twelve: Age-standardised* five-year relative survival rate, colon cancer, by sex, England and Wales, 1971-2006 * to the European standard population

17. © Cancer Research UK 2006 Registered charity number 1089464 Figure Thirteen: Age-standardised* five-year relative survival rate, rectal cancer, by sex, England and Wales, 1971-2006 * to the European standard population

18. © Cancer Research UK 2006 Registered charity number 1089464 Table Four: Approximate frequency and five-year relative survival (%) by Dukes' stage Dukes' Stage at diagnosis Percentage of cases Five-year relative survival A8.7%93.2% B24.2%77.0% C23.6%47.7% D9.2%6.6% Unknown 34.3%35.4%

19. © Cancer Research UK 2006 Registered charity number 1089464 Table Five: Number of deaths and mortality rates, colorectal cancer, UK, 2007 EnglandWalesScotlandN.IrelandUK Deaths Males6,8785258222498,474 Females6,1714317411907,533 Persons13,0499561,56343916,007 Crude rate per 100,000 population Males27.436.133.128.928.3 Females23.828.227.921.224.3 Persons25.532.130.425.026.3 Age-standardised rate (European) per 100,000 population Males21.325.725.826.822.1 CI 95%20.821.823.527.924.027.523.530.121.622.5 Females13.815.716.214.814.1 CI 95%13.414.114.217.215.117.412.716.913.814.5 Persons17.220.220.320.117.7 CI 95%16.917.518.921.519.321.318.222.017.418.0

20. © Cancer Research UK 2006 Registered charity number 1089464 Figure Fourteen: Percentage decrease in mortality rates, by age and sex, bowel cancer, UK, 1998-2007